{"id":"https://openalex.org/W2051664585","doi":"https://doi.org/10.1080/07391102.2009.10507285","title":"Molecular Dynamics Simulations to Investigate the Structural Stability and Aggregation Behavior of the GGVVIA Oligomers Derived from Amyloid \u03b2 Peptide","display_name":"Molecular Dynamics Simulations to Investigate the Structural Stability and Aggregation Behavior of the GGVVIA Oligomers Derived from Amyloid \u03b2 Peptide","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2051664585","doi":"https://doi.org/10.1080/07391102.2009.10507285","mag":"2051664585","pmid":"https://pubmed.ncbi.nlm.nih.gov/19385701"},"language":"en","primary_location":{"id":"doi:10.1080/07391102.2009.10507285","doi":"https://doi.org/10.1080/07391102.2009.10507285","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2009.10507285","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2051664585"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007773642","display_name":"Liang-Kai Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118292597","display_name":"National Taipei University of Technology","ror":"https://ror.org/00cn92c09","country_code":"TW","type":"education","lineage":["https://openalex.org/I118292597"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Liang-Kai Chang","raw_affiliation_strings":["Graduate Institute of Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei 10608, Taiwan","Graduate Institute of Biotechnology National Taipei University of Technology , 1 Sec. 3 ZhongXiao E. Rd., Taipei , Taiwan , 10608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei 10608, Taiwan","institution_ids":["https://openalex.org/I118292597"]},{"raw_affiliation_string":"Graduate Institute of Biotechnology National Taipei University of Technology , 1 Sec. 3 ZhongXiao E. Rd., Taipei , Taiwan , 10608","institution_ids":["https://openalex.org/I118292597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109953440","display_name":"Jian-Hua Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118292597","display_name":"National Taipei University of Technology","ror":"https://ror.org/00cn92c09","country_code":"TW","type":"education","lineage":["https://openalex.org/I118292597"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jian-Hua Zhao","raw_affiliation_strings":["Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei, Taiwan, 10608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei, Taiwan, 10608","institution_ids":["https://openalex.org/I118292597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007711695","display_name":"Hsuan\u2010Liang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118292597","display_name":"National Taipei University of Technology","ror":"https://ror.org/00cn92c09","country_code":"TW","type":"education","lineage":["https://openalex.org/I118292597"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsuan-Liang Liu","raw_affiliation_strings":["Graduate Institute of Biotechnology National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei, Taiwan, 10608 ; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei, Taiwan, 10608","Department of Chemical Engineering and Biotechnology , National Taipei University of Technology , 1 Sec. 3 ZhongXiao E. Rd., Taipei , Taiwan , 10608","Graduate Institute of Biotechnology National Taipei University of Technology , 1 Sec. 3 ZhongXiao E. Rd., Taipei , Taiwan , 10608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biotechnology National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei, Taiwan, 10608 ; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec. 3 ZhongXiao E. Rd., Taipei, Taiwan, 10608","institution_ids":["https://openalex.org/I118292597"]},{"raw_affiliation_string":"Department of Chemical Engineering and Biotechnology , National Taipei University of Technology , 1 Sec. 3 ZhongXiao E. Rd., Taipei , Taiwan , 10608","institution_ids":["https://openalex.org/I118292597"]},{"raw_affiliation_string":"Graduate Institute of Biotechnology National Taipei University of Technology , 1 Sec. 3 ZhongXiao E. Rd., Taipei , Taiwan , 10608","institution_ids":["https://openalex.org/I118292597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110271320","display_name":"Kung-Tien Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140015","display_name":"Institute of Nuclear Energy Research","ror":"https://ror.org/052jx3443","country_code":"TW","type":"government","lineage":["https://openalex.org/I2802216821","https://openalex.org/I4210140015"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kung-Tien Liu","raw_affiliation_strings":["Chemical Analysis Division, Institute of Nuclear Energy Research, 1000, Wunhua Rd., Longtan Township, Taoyuan County, Taiwan, 32546"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Analysis Division, Institute of Nuclear Energy Research, 1000, Wunhua Rd., Longtan Township, Taoyuan County, Taiwan, 32546","institution_ids":["https://openalex.org/I4210140015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027282320","display_name":"Jenn-Tzong Chen","orcid":"https://orcid.org/0000-0003-1001-0280","observed_orcids":["https://orcid.org/0000-0003-1001-0280"]},"institutions":[{"id":"https://openalex.org/I4210140015","display_name":"Institute of Nuclear Energy Research","ror":"https://ror.org/052jx3443","country_code":"TW","type":"government","lineage":["https://openalex.org/I2802216821","https://openalex.org/I4210140015"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jenn-Tzong Chen","raw_affiliation_strings":["Isotope Application Division, Institute of Nuclear Energy Research, 1000, Wunhua Rd., Longtan Township, Taoyuan County, Taiwan, 32546"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isotope Application Division, Institute of Nuclear Energy Research, 1000, Wunhua Rd., Longtan Township, Taoyuan County, Taiwan, 32546","institution_ids":["https://openalex.org/I4210140015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073049010","display_name":"Wei\u2010Bor Tsai","orcid":"https://orcid.org/0000-0002-2316-5751","observed_orcids":["https://orcid.org/0000-0002-2316-5751"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Bor Tsai","raw_affiliation_strings":["Department of Chemical Engineering, National Taiwan University, 1 Sec. 4 Roosevelt Rd., Taipei, Taiwan, 106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, National Taiwan University, 1 Sec. 4 Roosevelt Rd., Taipei, Taiwan, 106","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103791109","display_name":"Yih Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yih Ho","raw_affiliation_strings":["School of Pharmacy, Taipei Medical University, 250 Wu-Hsing St., Taipei, Taiwan, 110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Taipei Medical University, 250 Wu-Hsing St., Taipei, Taiwan, 110","institution_ids":["https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0127,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90988998,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"26","issue":"6","first_page":"731","last_page":"740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steric-zipper","display_name":"steric zipper","score":0.7889999747276306},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.6940000057220459},{"id":"https://openalex.org/keywords/glycine-substitution","display_name":"glycine substitution","score":0.6069999933242798},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C105782903","wikidata":"https://www.wikidata.org/wiki/Q6577686","display_name":"Zipper","level":2,"score":0.9249991178512573},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.8145687580108643},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.7332161068916321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6907373666763306},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.6776946187019348},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6003574728965759},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5948560237884521},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5255445241928101},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.48808085918426514},{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.4568323791027069},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.44704368710517883},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.40356940031051636},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2856631875038147},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.2154974341392517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17951735854148865},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.1513051986694336},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07216909527778625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06545796990394592},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/07391102.2009.10507285","doi":"https://doi.org/10.1080/07391102.2009.10507285","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2009.10507285","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},{"id":"pmid:19385701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19385701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular structure & dynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W20120559","https://openalex.org/W1545063083","https://openalex.org/W1967733770","https://openalex.org/W1973897761","https://openalex.org/W1977482735","https://openalex.org/W1978548150","https://openalex.org/W1986139836","https://openalex.org/W1986888773","https://openalex.org/W1989886744","https://openalex.org/W1990405999","https://openalex.org/W1991388423","https://openalex.org/W1992349385","https://openalex.org/W1997005464","https://openalex.org/W2001928135","https://openalex.org/W2003445150","https://openalex.org/W2004400100","https://openalex.org/W2014272598","https://openalex.org/W2014451295","https://openalex.org/W2017701206","https://openalex.org/W2018880174","https://openalex.org/W2019408667","https://openalex.org/W2025842121","https://openalex.org/W2029018340","https://openalex.org/W2035001102","https://openalex.org/W2042036635","https://openalex.org/W2044448989","https://openalex.org/W2057709942","https://openalex.org/W2075481535","https://openalex.org/W2085146429","https://openalex.org/W2088865014","https://openalex.org/W2093067743","https://openalex.org/W2096410114","https://openalex.org/W2097503860","https://openalex.org/W2103298870","https://openalex.org/W2110428391","https://openalex.org/W2113979052","https://openalex.org/W2114697669","https://openalex.org/W2134293050","https://openalex.org/W2139282850","https://openalex.org/W2142186280","https://openalex.org/W2143678630","https://openalex.org/W2154133125","https://openalex.org/W2161379168","https://openalex.org/W2163210644","https://openalex.org/W2164342885","https://openalex.org/W2165319412","https://openalex.org/W2167366010","https://openalex.org/W2622118579","https://openalex.org/W2950106487"],"related_works":["https://openalex.org/W2038530943","https://openalex.org/W2012814922","https://openalex.org/W2974550267","https://openalex.org/W1965822959","https://openalex.org/W1973527408","https://openalex.org/W2046331206","https://openalex.org/W1974188295","https://openalex.org/W2118518690","https://openalex.org/W2261378119","https://openalex.org/W2035001102"],"abstract_inverted_index":{"Several":[0],"neurodegenerative":[1],"diseases,":[2,9],"such":[3],"as":[4,51,112],"Alzheimer's,":[5],"Parkinson's,":[6],"and":[7,40,72,135,155,174],"Huntington's":[8],"are":[10],"associated":[11],"with":[12,62,79,99],"amyloid":[13,118],"fibrils":[14],"formed":[15,147],"by":[16],"different":[17],"polypeptides.":[18],"Recently,":[19],"the":[20,24,29,69,76,90,94,101,129,137,143,149,163,178,188,191,201,205,209,224],"atomic":[21,210],"structure":[22,46],"of":[23,33,75,84,93,103,152,190,204,227],"amyloid-forming":[25],"peptide":[26,36],"GGVVIA":[27,77,95,138,206],"from":[28],"C-terminal":[30],"hydrophobic":[31,126,144,179],"segment":[32],"amyloid-beta":[34],"(Abeta)":[35],"has":[37],"been":[38],"determined":[39],"revealed":[41],"a":[42,113,158],"dry,":[43],"tightly":[44],"self-complementing":[45],"between":[47,140,182],"two":[48,164,184],"beta-sheets,":[49,185],"termed":[50],"\"steric":[52],"zipper\".":[53],"In":[54],"this":[55],"study,":[56],"several":[57],"all-atom":[58],"molecular":[59],"dynamics":[60],"simulations":[61],"explicit":[63],"water":[64],"were":[65],"conducted":[66],"to":[67,133,222],"investigate":[68],"structural":[70,91],"stability":[71,92],"aggregation":[73,202],"behavior":[74,203],"oligomers":[78,96,139,207],"various":[80],"sizes.":[81],"The":[82],"results":[83,122,195],"our":[85],"single-layer":[86],"models":[87],"suggested":[88],"that":[89,108,125],"increases":[97],"remarkably":[98],"increasing":[100],"numbers":[102],"beta-strands.":[104],"We":[105],"further":[106],"identified":[107],"SH2-ST2":[109],"may":[110,213],"act":[111],"stable":[114],"seed":[115],"in":[116,161,187,208],"prompting":[117],"fibril":[119,225],"formations.":[120],"Our":[121,193],"also":[123,214],"demonstrated":[124],"interaction":[127],"is":[128],"principle":[130],"driving":[131],"force":[132],"stabilize":[134],"associate":[136],"beta-strands;":[141],"while":[142],"steric":[145,180],"zipper":[146,181],"via":[148],"side":[150],"chains":[151],"V3,":[153,172],"V4,":[154,173],"I5":[156,175],"plays":[157],"critical":[159],"role":[160],"holding":[162],"neighboring":[165],"beta-sheets":[166],"together.":[167],"Single":[168],"glycine":[169],"substitution":[170],"at":[171],"directly":[176],"disrupted":[177],"these":[183],"resulting":[186],"destabilization":[189],"oligomers.":[192],"simulation":[194],"provided":[196],"detailed":[197],"insights":[198],"into":[199],"understanding":[200],"level.":[211],"It":[212],"be":[215],"helpful":[216],"for":[217],"designing":[218],"new":[219],"inhibitors":[220],"able":[221],"prevent":[223],"formation":[226],"Abeta":[228],"peptide.":[229]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
