{"id":"https://openalex.org/W2051655321","doi":"https://doi.org/10.1016/j.jep.2010.09.007","title":"Involvement of p38 MAPK signaling pathway in the anti-melanogenic effect of San-bai-tang, a Chinese herbal formula, in B16 cells","display_name":"Involvement of p38 MAPK signaling pathway in the anti-melanogenic effect of San-bai-tang, a Chinese herbal formula, in B16 cells","publication_year":2010,"publication_date":"2010-09-17","ids":{"openalex":"https://openalex.org/W2051655321","doi":"https://doi.org/10.1016/j.jep.2010.09.007","mag":"2051655321","pmid":"https://pubmed.ncbi.nlm.nih.gov/20837127"},"language":"en","primary_location":{"id":"doi:10.1016/j.jep.2010.09.007","doi":"https://doi.org/10.1016/j.jep.2010.09.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2010.09.007","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100662711","display_name":"Ye Yan","orcid":"https://orcid.org/0000-0003-0847-561X","observed_orcids":["https://orcid.org/0000-0003-0847-561X"]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yan Ye","raw_affiliation_strings":["Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102406357","display_name":"Jian\u2010Hong Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jian-Hong Chu","raw_affiliation_strings":["Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460815","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0002-6278-1506","observed_orcids":["https://orcid.org/0000-0002-6278-1506"]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":["Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Xu","raw_affiliation_strings":["Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054942804","display_name":"Gui\u2010Xin Chou","orcid":"https://orcid.org/0000-0002-3561-0381","observed_orcids":["https://orcid.org/0000-0002-3561-0381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gui-Xin Chou","raw_affiliation_strings":["Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084492215","display_name":"Alexander Kai\u2010Man Leung","orcid":"https://orcid.org/0000-0002-0807-8211","observed_orcids":["https://orcid.org/0000-0002-0807-8211"]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Alexander Kai-Man Leung","raw_affiliation_strings":["Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113526633","display_name":"Wang Fun Fong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Wang-fun Fong","raw_affiliation_strings":["Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013824415","display_name":"Zhi\u2010Ling Yu","orcid":"https://orcid.org/0000-0002-2979-9608","observed_orcids":["https://orcid.org/0000-0002-2979-9608","https://orcid.org/0000-0002-1021-215X"]},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Zhi-Ling Yu","raw_affiliation_strings":["Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China","institution_ids":["https://openalex.org/I141568987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013824415"],"corresponding_institution_ids":["https://openalex.org/I141568987"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.8669,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.83629993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"132","issue":"2","first_page":"533","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p38-mapk-signaling-pathway","display_name":"p38 MAPK signaling pathway","score":0.906000018119812},{"id":"https://openalex.org/keywords/melanogenesis-inhibition","display_name":"melanogenesis inhibition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/tyrosinase-inhibition","display_name":"tyrosinase inhibition","score":0.9459999799728394},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.9649999737739563},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/trp-2","display_name":"TRP-2","score":1.0},{"id":"https://openalex.org/keywords/melanin-content","display_name":"melanin content","score":0.8159999847412109},{"id":"https://openalex.org/keywords/traditional-chinese-medicine-formula","display_name":"traditional Chinese medicine formula","score":0.8379999995231628},{"id":"https://openalex.org/keywords/skin-lightening","display_name":"skin lightening","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6260448694229126},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5530866384506226},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5056972503662109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49500006437301636},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.46189960837364197},{"id":"https://openalex.org/C2781380062","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Folk medicine","level":2,"score":0.42902445793151855},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.4203995168209076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3848080635070801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2773128151893616},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.19832941889762878},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1624329686164856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15504124760627747},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09205988049507141},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029596","descriptor_name":"Paeonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031174","descriptor_name":"Atractylodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032281","descriptor_name":"Smilax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jep.2010.09.007","doi":"https://doi.org/10.1016/j.jep.2010.09.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2010.09.007","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},{"id":"pmid:20837127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20837127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ethnopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.hkbu.edu.hk:hkbu_staff_publication-2701","doi":null,"is_oa":false,"landing_page_url":"https://repository.hkbu.edu.hk/hkbu_staff_publication/1687","pdf_url":null,"source":{"id":"https://openalex.org/S4377196872","display_name":"HKBU Institutional Repository (Hong Kong Baptist University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141568987","host_organization_name":"Hong Kong Baptist University","host_organization_lineage":["https://openalex.org/I141568987"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HKBU Staff Publication","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1498389773","https://openalex.org/W1985729602","https://openalex.org/W1986570146","https://openalex.org/W1987108678","https://openalex.org/W1995566954","https://openalex.org/W2006649737","https://openalex.org/W2015728302","https://openalex.org/W2038633534","https://openalex.org/W2052921676","https://openalex.org/W2058537236","https://openalex.org/W2070326078","https://openalex.org/W2075013674","https://openalex.org/W2076956498","https://openalex.org/W2077734227","https://openalex.org/W2083411239","https://openalex.org/W2088156696","https://openalex.org/W2109825099","https://openalex.org/W2123986910","https://openalex.org/W2162730446","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W2031201851","https://openalex.org/W2153698712","https://openalex.org/W2769060708","https://openalex.org/W2043576186","https://openalex.org/W1604933407","https://openalex.org/W174995411","https://openalex.org/W2037193716","https://openalex.org/W2947371395","https://openalex.org/W1968873996","https://openalex.org/W3126542969"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}