{"id":"https://openalex.org/W2051642064","doi":"https://doi.org/10.1038/clpt.2011.236","title":"Comparative-Effectiveness Research in Distributed Health Data Networks","display_name":"Comparative-Effectiveness Research in Distributed Health Data Networks","publication_year":2011,"publication_date":"2011-10-26","ids":{"openalex":"https://openalex.org/W2051642064","doi":"https://doi.org/10.1038/clpt.2011.236","mag":"2051642064","pmid":"https://pubmed.ncbi.nlm.nih.gov/22030567"},"language":"en","primary_location":{"id":"doi:10.1038/clpt.2011.236","doi":"https://doi.org/10.1038/clpt.2011.236","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.2011.236","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067236770","display_name":"Sengwee Toh","orcid":"https://orcid.org/0000-0002-5160-0810","observed_orcids":["https://orcid.org/0000-0002-5160-0810"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S Toh","raw_affiliation_strings":["Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA","Department of Population Medicine; Harvard Medical School/Harvard Pilgrim Health Care Institute; Boston Massachusetts USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]},{"raw_affiliation_string":"Department of Population Medicine; Harvard Medical School/Harvard Pilgrim Health Care Institute; Boston Massachusetts USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014967450","display_name":"Richard G. Platt","orcid":"https://orcid.org/0000-0002-3248-3583","observed_orcids":["https://orcid.org/0000-0002-3248-3583"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Platt","raw_affiliation_strings":["Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056204870","display_name":"John F. Steiner","orcid":"https://orcid.org/0000-0002-6514-6057","observed_orcids":["https://orcid.org/0000-0002-6514-6057"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J F Steiner","raw_affiliation_strings":["Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado, USA","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060381803","display_name":"Jeffrey Scott Brown","orcid":"https://orcid.org/0000-0002-9340-7189","observed_orcids":["https://orcid.org/0000-0002-9340-7189"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Brown","raw_affiliation_strings":["Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067236770"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":10.7744,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.98450435,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"90","issue":"6","first_page":"883","last_page":"887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.6646000146865845,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.6646000146865845,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10764","display_name":"Privacy-Preserving Technologies in Data","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comparative-effectiveness-research","display_name":"comparative effectiveness research","score":0.9559999704360962},{"id":"https://openalex.org/keywords/network-architecture","display_name":"network architecture","score":0.8130000233650208},{"id":"https://openalex.org/keywords/data-infrastructure","display_name":"data infrastructure","score":0.5839999914169312},{"id":"https://openalex.org/keywords/patient-privacy","display_name":"patient privacy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/data-security","display_name":"data security","score":0.996999979019165},{"id":"https://openalex.org/keywords/data-sharing","display_name":"data sharing","score":0.5910000205039978},{"id":"https://openalex.org/keywords/interoperability","display_name":"interoperability","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2778111679","wikidata":"https://www.wikidata.org/wiki/Q5155639","display_name":"Comparative effectiveness research","level":3,"score":0.6942356824874878},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.670830488204956},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6494166851043701},{"id":"https://openalex.org/C3017977704","wikidata":"https://www.wikidata.org/wiki/Q18745135","display_name":"Health data","level":3,"score":0.5190492272377014},{"id":"https://openalex.org/C47487241","wikidata":"https://www.wikidata.org/wiki/Q5227230","display_name":"Data access","level":2,"score":0.4840683043003082},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.43302756547927856},{"id":"https://openalex.org/C3020038283","wikidata":"https://www.wikidata.org/wiki/Q42848","display_name":"Research data","level":3,"score":0.4204120635986328},{"id":"https://openalex.org/C10511746","wikidata":"https://www.wikidata.org/wiki/Q899388","display_name":"Data security","level":3,"score":0.41943010687828064},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.419163316488266},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.4095745384693146},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.24430668354034424},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.21208125352859497},{"id":"https://openalex.org/C91632574","wikidata":"https://www.wikidata.org/wiki/Q15088675","display_name":"Data curation","level":2,"score":0.13265463709831238},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C148730421","wikidata":"https://www.wikidata.org/wiki/Q141090","display_name":"Encryption","level":2,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003195","descriptor_name":"Computer Communication Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003219","descriptor_name":"Confidentiality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003695","descriptor_name":"Delivery of Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016494","descriptor_name":"Computer Security","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057186","descriptor_name":"Comparative Effectiveness Research","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/clpt.2011.236","doi":"https://doi.org/10.1038/clpt.2011.236","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.2011.236","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:22030567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22030567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/1015225","doi":null,"is_oa":false,"landing_page_url":"http://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Comparative-effectiveness+research+in+distributed+health+data+networks.&title=Clinical+pharmacology+and+therapeutics+&volume=90&issue=6&date=2011-12&au=Toh,+S;+Platt,+R;+Steiner,+J+F;+Brown,+J+S","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:341151","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6964268058","display_name":null,"funder_award_id":"1R01HS019912","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"}],"funders":[{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1583805608","https://openalex.org/W1963672880","https://openalex.org/W1986087095","https://openalex.org/W2013990326","https://openalex.org/W2029421943","https://openalex.org/W2030147903","https://openalex.org/W2056360854","https://openalex.org/W2082371264","https://openalex.org/W2083990413","https://openalex.org/W2088263677","https://openalex.org/W2090465492","https://openalex.org/W2090483525","https://openalex.org/W2092970016","https://openalex.org/W2100837203","https://openalex.org/W2111207992","https://openalex.org/W2127657997","https://openalex.org/W2129471004","https://openalex.org/W2130219862","https://openalex.org/W2150691335","https://openalex.org/W2160537733","https://openalex.org/W2168490079","https://openalex.org/W2413615075","https://openalex.org/W2460982581"],"related_works":["https://openalex.org/W2026320530","https://openalex.org/W2890064903","https://openalex.org/W1963672880","https://openalex.org/W2147518658","https://openalex.org/W2137285932","https://openalex.org/W2053710796","https://openalex.org/W7097632151","https://openalex.org/W2111207992","https://openalex.org/W1954551871","https://openalex.org/W2187925591"],"abstract_inverted_index":{"Comparative-effectiveness":[0],"research":[1],"(CER)":[2],"can":[3],"be":[4],"conducted":[5],"within":[6],"a":[7,44],"distributed":[8],"health":[9],"data":[10,19,23,34,53],"network.":[11],"Such":[12],"networks":[13],"allow":[14],"secure":[15],"access":[16],"to":[17,31],"separate":[18],"sets":[20],"from":[21],"different":[22],"partners":[24],"and":[25,36,50],"overcome":[26],"many":[27],"practical":[28],"obstacles":[29],"related":[30],"patient":[32],"privacy,":[33],"security,":[35],"proprietary":[37],"concerns.":[38],"A":[39],"scalable":[40],"network":[41],"architecture":[42],"supports":[43],"wide":[45],"range":[46],"of":[47],"CER":[48],"activities":[49],"meets":[51],"the":[52,58],"infrastructure":[54],"needs":[55],"envisioned":[56],"by":[57],"Federal":[59],"Coordinating":[60],"Council":[61],"for":[62],"Comparative":[63],"Effectiveness":[64],"Research.":[65]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}