{"id":"https://openalex.org/W2051615828","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb03779.x","title":"Activation and Inactivation of Oxytocin and Vasopressin Release from Isolated Nerve Endings (Neurosecretosomes) of the Rat Neurohypophysis","display_name":"Activation and Inactivation of Oxytocin and Vasopressin Release from Isolated Nerve Endings (Neurosecretosomes) of the Rat Neurohypophysis","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W2051615828","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb03779.x","mag":"2051615828","pmid":"https://pubmed.ncbi.nlm.nih.gov/2072100"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1991.tb03779.x","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb03779.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1991.tb03779.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024209998","display_name":"Kemal Payza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kemal Payza","raw_affiliation_strings":["Unit on Neuronal Secretory Systems, NICHD, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit on Neuronal Secretory Systems, NICHD, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113977290","display_name":"James T. Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James T. Russell","raw_affiliation_strings":["Unit on Neuronal Secretory Systems, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit on Neuronal Secretory Systems, Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113977290"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":2.0159,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.87333762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"2","first_page":"499","last_page":"508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.4706999957561493,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.4706999957561493,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.15049999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.14509999752044678,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":1.0},{"id":"https://openalex.org/keywords/neurosecretory-terminals","display_name":"neurosecretory terminals","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neurohypophysis","display_name":"neurohypophysis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hormone-secretion","display_name":"hormone secretion","score":0.8799999952316284},{"id":"https://openalex.org/keywords/calcium-dependent-secretion","display_name":"calcium-dependent secretion","score":0.6539999842643738},{"id":"https://openalex.org/keywords/depolarization","display_name":"depolarization","score":0.6439999938011169},{"id":"https://openalex.org/keywords/potassium-evoked-release","display_name":"potassium-evoked release","score":0.4950000047683716},{"id":"https://openalex.org/keywords/veratridine","display_name":"veratridine","score":0.921999990940094},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.7329999804496765},{"id":"https://openalex.org/keywords/omega-conotoxin","display_name":"omega-conotoxin","score":0.7929999828338623},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.6389999985694885},{"id":"https://openalex.org/keywords/dynorphin","display_name":"dynorphin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/u-50488","display_name":"U50,488","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ionomycin","display_name":"ionomycin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.9354456663131714},{"id":"https://openalex.org/C136357698","wikidata":"https://www.wikidata.org/wiki/Q3290037","display_name":"Free nerve ending","level":2,"score":0.9041462540626526},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.8570125102996826},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5286070704460144},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4961298406124115},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46150094270706177},{"id":"https://openalex.org/C2984443765","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Nerve cells","level":2,"score":0.46004724502563477},{"id":"https://openalex.org/C2778991426","wikidata":"https://www.wikidata.org/wiki/Q3338699","display_name":"Neurosecretion","level":2,"score":0.45019862055778503},{"id":"https://openalex.org/C2776711897","wikidata":"https://www.wikidata.org/wiki/Q5974727","display_name":"Liberation","level":3,"score":0.4320865571498871},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.415549099445343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4072878360748291},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3093777298927307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29556041955947876},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2249700129032135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21855095028877258},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12336468696594238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10736808180809021}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005711","descriptor_name":"Gallopamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010904","descriptor_name":"Pituitary Gland, Posterior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010904","descriptor_name":"Pituitary Gland, Posterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014701","descriptor_name":"Veratridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015759","descriptor_name":"Ionomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1991.tb03779.x","doi":"https://doi.org/10.1111/j.1471-4159.1991.tb03779.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1991.tb03779.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:2072100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2072100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W283231370","https://openalex.org/W284521342","https://openalex.org/W1614399163","https://openalex.org/W1967595797","https://openalex.org/W1972271258","https://openalex.org/W1979418712","https://openalex.org/W1990005793","https://openalex.org/W2004871139","https://openalex.org/W2007973974","https://openalex.org/W2014067967","https://openalex.org/W2019815430","https://openalex.org/W2020391012","https://openalex.org/W2021413809","https://openalex.org/W2024604367","https://openalex.org/W2031679821","https://openalex.org/W2032221526","https://openalex.org/W2033808636","https://openalex.org/W2040832060","https://openalex.org/W2042116226","https://openalex.org/W2048638406","https://openalex.org/W2049048996","https://openalex.org/W2050649335","https://openalex.org/W2055053898","https://openalex.org/W2055736577","https://openalex.org/W2060104932","https://openalex.org/W2066199544","https://openalex.org/W2067534967","https://openalex.org/W2070830140","https://openalex.org/W2073270579","https://openalex.org/W2110751559","https://openalex.org/W2126697794","https://openalex.org/W2135472547","https://openalex.org/W2137812689","https://openalex.org/W2152112825","https://openalex.org/W2161947855","https://openalex.org/W2165517992","https://openalex.org/W2183635690","https://openalex.org/W2210683287","https://openalex.org/W2936260338","https://openalex.org/W3010853791","https://openalex.org/W4243536530"],"related_works":["https://openalex.org/W1971160907","https://openalex.org/W2020391012","https://openalex.org/W2045673001","https://openalex.org/W2033808636","https://openalex.org/W2055127800","https://openalex.org/W1587644247","https://openalex.org/W1967595797","https://openalex.org/W2479967828","https://openalex.org/W2141687501","https://openalex.org/W1945168745"],"abstract_inverted_index":{"Neurosecretory":[0],"terminals":[1],"(neurosecretosomes,":[2],"NSS)":[3],"were":[4,163],"isolated":[5],"from":[6,36],"rat":[7],"neurohypophyses.":[8],"High":[9,84],"[K+]o":[10,85],"or":[11,239],"veratridine":[12],"stimulated":[13],"secretion":[14,25,50,103,116,135,139,149,162,203,228],"of":[15,47,82,142,159,168,190,199,241],"vasopressin":[16],"and":[17,30,32,63,67,72,173,180,217],"oxytocin":[18],"by":[19,54,106],"up":[20],"to":[21,123,153,214,236],"approximately":[22],"100-fold.":[23],"Stimulated":[24],"was":[26,51,104,150,204],"dependent":[27,206],"on":[28,140,207],"calcium":[29,55,81,94,132,209],"temperature,":[31],"could":[33],"be":[34,234],"elicited":[35],"NSS":[37],"maintained":[38],"in":[39,102,148,161,196,227],"culture":[40,46],"for":[41,80,128,165,178],"4":[42],"days.":[43],"After":[44],"overnight":[45],"the":[48,87,100,114,146,157,188,197,201,225],"NSS,":[49],"still":[52,205],"inhibited":[53],"channel":[56],"blockers":[57],"(cobalt,":[58],"dihydropyridines,":[59],"omega-conotoxin,":[60],"D":[61,109,215],"600)":[62],"kappa":[64],"opiates":[65],"(dynorphin":[66],"U50488).":[68],"Ionomycin":[69],"evoked":[70],"dose-":[71],"calcium-dependent":[73],"hormone":[74,115],"release,":[75],"with":[76],"a":[77,242],"Hill":[78],"coefficient":[79],"1.74.":[83],"enhanced":[86],"5":[88],"microM":[89,108],"ionomycin-induced":[90],"secretion,":[91],"apparently":[92],"through":[93,211],"entry":[95],"rather":[96],"than":[97],"depolarization,":[98],"as":[99],"increase":[101],"abolished":[105],"100":[107],"600.":[110],"During":[111],"prolonged":[112,230],"depolarization":[113,169,192],"peaked":[117],"within":[118],"2":[119],"min,":[120],"then":[121],"declined":[122],"near":[124],"basal":[125],"levels.":[126],"Depolarization":[127],"25":[129,179],"min":[130],"without":[131],"neither":[133],"activated":[134],"nor":[136],"prevented":[137],"subsequent":[138],"readdition":[141],"calcium,":[143,200],"suggesting":[144],"that":[145,224],"decline":[147,160,226],"not":[151],"due":[152,235],"membrane":[154],"depolarization.":[155],"Indeed,":[156],"rates":[158],"similar":[164],"different":[166],"levels":[167],"(0.070":[170],"+/-":[171,175],"0.003":[172,176],"0.081":[174],"min-1":[177],"45":[181],"mM":[182,194],"[K+]o,":[183],"respectively).":[184],"Four":[185],"minutes":[186],"after":[187],"onset":[189],"continuous":[191],"(45":[193],"[K+]o)":[195],"presence":[198],"declining":[202],"voltage-activated":[208],"influx":[210],"channels":[212],"sensitive":[213],"600":[216],"nitrendipine.":[218],"The":[219],"results":[220],"presented":[221],"here":[222],"suggest":[223],"during":[229],"depolarizing":[231],"stimuli":[232],"may":[233],"exhaustion,":[237],"inactivation,":[238],"desensitization":[240],"calcium-triggered":[243],"event.":[244]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
