{"id":"https://openalex.org/W2051556871","doi":"https://doi.org/10.1021/ja015867r","title":"Dimerizable Cationic Detergents with a Low cmc Condense Plasmid DNA into Nanometric Particles and Transfect Cells in Culture","display_name":"Dimerizable Cationic Detergents with a Low cmc Condense Plasmid DNA into Nanometric Particles and Transfect Cells in Culture","publication_year":2001,"publication_date":"2001-08-31","ids":{"openalex":"https://openalex.org/W2051556871","doi":"https://doi.org/10.1021/ja015867r","mag":"2051556871","pmid":"https://pubmed.ncbi.nlm.nih.gov/11562201"},"language":"en","primary_location":{"id":"doi:10.1021/ja015867r","doi":"https://doi.org/10.1021/ja015867r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja015867r","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045764394","display_name":"Emmanuel Dauty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuel Dauty","raw_affiliation_strings":["Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056478667","display_name":"Jean-Serge R\u00e9my","orcid":"https://orcid.org/0000-0002-3935-0433","observed_orcids":["https://orcid.org/0000-0002-3935-0433"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Serge Remy","raw_affiliation_strings":["Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110856834","display_name":"Thomas Blessing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Blessing","raw_affiliation_strings":["Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113607312","display_name":"Jean\u2010Paul Behr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Paul Behr","raw_affiliation_strings":["Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Laboratoire de Chimie G\u00e9n\u00e9tique associ\u00e9 CNRS/Universit\u00e9 Louis Pasteur de Strasbourg, Facult\u00e9 de Pharmacie BP 24, 67401 Illkirch, France","institution_ids":["https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1294671590"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1737,"has_fulltext":false,"cited_by_count":184,"citation_normalized_percentile":{"value":0.92849219,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"123","issue":"38","first_page":"9227","last_page":"9234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.13169999420642853,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmid-dna-condensation","display_name":"plasmid DNA condensation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-nanoparticles","display_name":"DNA nanoparticles","score":0.5649999976158142},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.8050000071525574},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.6499999761581421},{"id":"https://openalex.org/keywords/critical-micelle-concentration","display_name":"critical micelle concentration","score":0.8270000219345093},{"id":"https://openalex.org/keywords/thiol-oxidation","display_name":"thiol oxidation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/polymer-supported-synthesis","display_name":"polymer-supported synthesis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ornithine","display_name":"ornithine","score":0.7580000162124634},{"id":"https://openalex.org/keywords/spermine","display_name":"spermine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.5360000133514404},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.8050000071525574},{"id":"https://openalex.org/keywords/intracellular-trafficking","display_name":"intracellular trafficking","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9473859071731567},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.8418973684310913},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.8411586284637451},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.735160231590271},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5753118991851807},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3754962384700775},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3480299115180969},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3395337164402008},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16434389352798462},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.14619696140289307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10558044910430908},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000473","descriptor_name":"Alkanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013096","descriptor_name":"Spermine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ja015867r","doi":"https://doi.org/10.1021/ja015867r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja015867r","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:11562201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11562201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02476297v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02476297","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Chemical Society, 2001, 123 (38), pp.9227-9234. &#x27E8;10.1021/ja015867r&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:univoak.eu:islandora_89320","doi":null,"is_oa":false,"landing_page_url":"https://pubs.acs.org/doi/10.1021/ja015867r","pdf_url":null,"source":{"id":"https://openalex.org/S4306402449","display_name":"univOAK (4 institutions : Universit\u00e9 de Strasbourg, Universit\u00e9 de Haute Alsace, INSA Strasbourg, Biblioth\u00e8que Nationale et Universitaire de Strasbourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210100283","host_organization_name":"Laboratoire des Sciences de l'Ing\u00e9nieur, de l'Informatique et de l'Imagerie","host_organization_lineage":["https://openalex.org/I4210100283"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1976811878","https://openalex.org/W1981274531","https://openalex.org/W1985542289","https://openalex.org/W2016726700","https://openalex.org/W2024201137","https://openalex.org/W2026835141","https://openalex.org/W2036945864","https://openalex.org/W2039872514","https://openalex.org/W2072983541","https://openalex.org/W2073417483","https://openalex.org/W2145034044","https://openalex.org/W2167949866","https://openalex.org/W2314225431","https://openalex.org/W2406272467","https://openalex.org/W4231635416"],"related_works":["https://openalex.org/W2088373879","https://openalex.org/W2058881774","https://openalex.org/W1982783187","https://openalex.org/W2326699906","https://openalex.org/W2080241938","https://openalex.org/W1981274531","https://openalex.org/W2501984453","https://openalex.org/W2022950118","https://openalex.org/W2091336697","https://openalex.org/W2005620262"],"abstract_inverted_index":{"The":[0,88,135,154],"size":[1,156],"of":[2,38,54,83,92,108,119,131,150,167,178],"condensed":[3],"DNA":[4,123,169,180],"particles":[5,31,110],"is":[6],"a":[7,42,52,71,117,128,141],"key":[8],"determinant":[9],"for":[10,194],"in":[11,183],"vivo":[12,184],"diffusion":[13,185],"and":[14,63,79,90,105,147,186],"gene":[15,50],"delivery":[16],"to":[17,173],"cells.":[18],"Gene":[19],"molecules":[20,124],"can":[21],"be":[22,174,192],"individually":[23],"compacted":[24],"by":[25,35],"cationic":[26,55],"thiol":[27,56,80],"detergents":[28,57,85],"into":[29,41,127],"nanometric":[30],"that":[32,177],"are":[33],"stabilized":[34],"oxidative":[36],"conversion":[37],"the":[39,47,84,101,109,114,163,168],"detergent":[40],"gemini":[43],"lipid.":[44],"To":[45],"reach":[46],"other":[48],"goal,":[49],"delivery,":[51],"series":[53],"with":[58,95,160],"various":[59],"chain":[60],"lengths":[61],"(C(12)-C(16))":[62],"headgroups":[64],"(ornithine":[65],"or":[66],"spermine)":[67],"was":[68,125,148,171],"prepared,":[69],"using":[70],"versatile":[72],"polymer-supported":[73],"synthetic":[74],"strategy.":[75],"Critical":[76],"micelle":[77],"concentrations":[78],"oxidation":[81],"rates":[82],"were":[86,111],"measured.":[87],"formation":[89],"stability":[91],"complexes":[93,170],"formed":[94],"plasmid":[96,122,179],"DNA,":[97],"as":[98,100],"well":[99],"size,":[102],"xi-potential,":[103],"morphology,":[104],"transfection":[106],"efficiency":[107],"investigated.":[112],"Using":[113],"tetradecane/ornithine":[115],"detergent,":[116,137],"solution":[118],"5.5":[120],"Kpb":[121],"converted":[126],"homogeneous":[129],"population":[130],"35":[132],"nm":[133],"particles.":[134],"same":[136],"once":[138],"oxidized,":[139],"exhibited":[140],"typical":[142],"lipid":[143],"phase":[144],"internal":[145],"structure":[146],"capable":[149],"effective":[151],"cell":[152],"transfection.":[153],"particle":[155],"did":[157],"not":[158],"increase":[159],"time.":[161],"Surprisingly,":[162],"gel":[164],"electrophoretic":[165],"mobility":[166],"found":[172],"higher":[175],"than":[176],"itself.":[181],"Favorable":[182],"intracellular":[187],"trafficking":[188],"properties":[189],"may":[190],"thus":[191],"expected":[193],"these":[195],"complexes.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
