{"id":"https://openalex.org/W2051538883","doi":"https://doi.org/10.7326/0003-4819-139-5_part_2-200309021-00009","title":"Improving Medication Use for Older Adults: An Integrated Research Agenda","display_name":"Improving Medication Use for Older Adults: An Integrated Research Agenda","publication_year":2003,"publication_date":"2003-09-02","ids":{"openalex":"https://openalex.org/W2051538883","doi":"https://doi.org/10.7326/0003-4819-139-5_part_2-200309021-00009","mag":"2051538883","pmid":"https://pubmed.ncbi.nlm.nih.gov/12965970"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-139-5_part_2-200309021-00009","doi":"https://doi.org/10.7326/0003-4819-139-5_part_2-200309021-00009","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-139-5_part_2-200309021-00009","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102846672","display_name":"Michael D. Murray","orcid":"https://orcid.org/0000-0002-7631-6138","observed_orcids":["https://orcid.org/0000-0002-7631-6138"]},"institutions":[{"id":"https://openalex.org/I1324682000","display_name":"Regenstrief Institute","ror":"https://ror.org/05f2ywb48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1324682000"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Murray","raw_affiliation_strings":["From Purdue University School of Pharmacy, Regenstrief Institute, and Indiana University Center for Aging Research, Indianapolis, Indiana","Purdue University School of Pharmacy, Regenstrief Institute, and Indiana University Center for Aging Research, Indianapolis, Indiana 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Purdue University School of Pharmacy, Regenstrief Institute, and Indiana University Center for Aging Research, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1324682000","https://openalex.org/I592451"]},{"raw_affiliation_string":"Purdue University School of Pharmacy, Regenstrief Institute, and Indiana University Center for Aging Research, Indianapolis, Indiana 46202, USA","institution_ids":["https://openalex.org/I1324682000","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022515998","display_name":"Christopher M. Callahan","orcid":"https://orcid.org/0000-0002-4617-6672","observed_orcids":["https://orcid.org/0000-0002-4617-6672"]},"institutions":[{"id":"https://openalex.org/I1324682000","display_name":"Regenstrief Institute","ror":"https://ror.org/05f2ywb48","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1324682000"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Callahan","raw_affiliation_strings":["From Purdue University School of Pharmacy, Regenstrief Institute, and Indiana University Center for Aging Research, Indianapolis, Indiana","General Internal Medicine & Geriatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Purdue University School of Pharmacy, Regenstrief Institute, and Indiana University Center for Aging Research, Indianapolis, Indiana","institution_ids":["https://openalex.org/I1324682000","https://openalex.org/I592451"]},{"raw_affiliation_string":"General Internal Medicine & Geriatrics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8639,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.59574468,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"139","issue":"5_Part_2","first_page":"425","last_page":"429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medication-use-in-older-adults","display_name":"medication use in older adults","score":0.9639999866485596},{"id":"https://openalex.org/keywords/geriatric-pharmacotherapy","display_name":"geriatric pharmacotherapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8209999799728394},{"id":"https://openalex.org/keywords/successful-aging","display_name":"successful aging","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pharmacoepidemiology","display_name":"pharmacoepidemiology","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-policy","display_name":"drug policy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/access-to-medicines","display_name":"access to medicines","score":0.6110000014305115},{"id":"https://openalex.org/keywords/pharmaceutical-databases","display_name":"pharmaceutical databases","score":0.5820000171661377},{"id":"https://openalex.org/keywords/knowledge-practice-gap","display_name":"knowledge-practice gap","score":0.902999997138977},{"id":"https://openalex.org/keywords/medication-self-management","display_name":"medication self-management","score":0.7820000052452087},{"id":"https://openalex.org/keywords/low-income-older-adults","display_name":"low-income elderly","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8626197576522827},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.6431294679641724},{"id":"https://openalex.org/C197636746","wikidata":"https://www.wikidata.org/wiki/Q7234359","display_name":"Postmarketing surveillance","level":3,"score":0.5459020733833313},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.5308262705802917},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.5228631496429443},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.48491793870925903},{"id":"https://openalex.org/C23276603","wikidata":"https://www.wikidata.org/wiki/Q158230","display_name":"Pharmacoepidemiology","level":3,"score":0.47001034021377563},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.4646700322628021},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45766690373420715},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44506949186325073},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.44062626361846924},{"id":"https://openalex.org/C54183767","wikidata":"https://www.wikidata.org/wiki/Q10384","display_name":"Geriatrics","level":2,"score":0.4234447479248047},{"id":"https://openalex.org/C2778858636","wikidata":"https://www.wikidata.org/wiki/Q1643563","display_name":"Prescription drug","level":3,"score":0.4172350764274597},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.41061872243881226},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32363641262054443},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23240965604782104},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2162923514842987},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D004363","descriptor_name":"Drug Utilization","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011640","descriptor_name":"Public Policy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D017891","descriptor_name":"Pharmacoepidemiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019338","descriptor_name":"Polypharmacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7326/0003-4819-139-5_part_2-200309021-00009","doi":"https://doi.org/10.7326/0003-4819-139-5_part_2-200309021-00009","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-139-5_part_2-200309021-00009","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:12965970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12965970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.993.5072","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.993.5072","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://annals.org/data/Journals/AIM/20048/0000605-200309021-00009.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1061202218","display_name":"CLINICAL PHARMACOLOGY OF LOOP DIURETICS","funder_award_id":"R01AG007631","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1831762215","display_name":"Improving Medication Use in Patients With Hypertension","funder_award_id":"R01HL069399","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5151050941","display_name":"IMPROVING DRUG USE FOR ELDERLY HEART FAILURE PATIENTS","funder_award_id":"R01AG019105","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1551753211","https://openalex.org/W1605279413","https://openalex.org/W1893944147","https://openalex.org/W1969388541","https://openalex.org/W1972412925","https://openalex.org/W1979589326","https://openalex.org/W1990482881","https://openalex.org/W1998645304","https://openalex.org/W1998672586","https://openalex.org/W2001511735","https://openalex.org/W2012947624","https://openalex.org/W2026015838","https://openalex.org/W2026375486","https://openalex.org/W2031766987","https://openalex.org/W2040044678","https://openalex.org/W2052806549","https://openalex.org/W2060253215","https://openalex.org/W2060313926","https://openalex.org/W2068721007","https://openalex.org/W2069040553","https://openalex.org/W2083020178","https://openalex.org/W2088203115","https://openalex.org/W2089954656","https://openalex.org/W2097867305","https://openalex.org/W2099445809","https://openalex.org/W2105814725","https://openalex.org/W2121336886","https://openalex.org/W2121445626","https://openalex.org/W2130501785","https://openalex.org/W2145137957","https://openalex.org/W2145259564","https://openalex.org/W2151512706","https://openalex.org/W2153767046","https://openalex.org/W2157452732","https://openalex.org/W2163925289","https://openalex.org/W2166919399","https://openalex.org/W2168465029","https://openalex.org/W2171787586","https://openalex.org/W2317316091","https://openalex.org/W2339692629","https://openalex.org/W2345813952","https://openalex.org/W2461149377","https://openalex.org/W2556753265","https://openalex.org/W4233470361"],"related_works":["https://openalex.org/W7095614310","https://openalex.org/W3166626911","https://openalex.org/W2052693414","https://openalex.org/W2044180916","https://openalex.org/W1986256408","https://openalex.org/W3133829468","https://openalex.org/W2913371162","https://openalex.org/W2033606512","https://openalex.org/W2018650563","https://openalex.org/W2118266749"],"abstract_inverted_index":{"Effective":[0],"health":[1,21,217],"care":[2,22],"is":[3,93,105],"a":[4,38,197],"core":[5],"determinant":[6],"of":[7,14,20,55,66,79,91,116,132,137,148,155,176,187,210,220,234,262],"successful":[8,96],"aging,":[9],"and":[10,45,81,160,164,167,170,174,184,196,218,256,258],"medications":[11,60,117],"are":[12,37,75,212],"one":[13,30],"the":[15,87,114,130,138,146,182,207,216,232,252,260],"most":[16],"important":[17,77,214],"therapeutic":[18],"tools":[19],"providers.":[23],"Most":[24],"older":[25,47,119,149,221,245,263],"adults":[26,48,246,264],"use":[27,90,115,136,175,243],"at":[28],"least":[29],"prescription":[31],"drug.":[32],"Costs":[33],"for":[34,42,109],"these":[35,51,84],"drugs":[36],"substantial":[39],"out-of-pocket":[40],"expense":[41],"Medicare":[43],"beneficiaries,":[44],"low-income":[46],"must":[49],"weigh":[50],"costs":[52],"against":[53],"those":[54],"other":[56],"basic":[57],"needs.":[58],"Although":[59],"bring":[61],"welcome":[62],"relief":[63],"to":[64,95,101,112,144,173,215,265],"millions":[65],"elderly":[67],"persons":[68],"with":[69],"age-related":[70],"conditions,":[71],"adverse":[72],"drug":[73,158,162,168,188],"events":[74],"an":[76,106],"cause":[78],"illness":[80],"death":[82],"in":[83,206,241],"patients.":[85],"Thus,":[86],"appropriate,":[88],"cost-effective":[89],"medication":[92,242],"central":[94],"aging.":[97],"Despite":[98],"increasing":[99,259],"attention":[100],"geriatric":[102],"pharmacotherapy,":[103],"there":[104],"enormous":[107],"need":[108],"additional":[110],"research":[111,123,191,211],"improve":[113,145],"among":[118,244],"adults.":[120,150,222],"The":[121],"necessary":[122],"agenda":[124],"encompasses":[125],"much":[126],"more":[127],"than":[128,200],"just":[129],"discovery":[131,159],"new":[133],"drugs;":[134],"better":[135,198],"current":[139],"pharmacopeia":[140],"has":[141,193],"great":[142],"potential":[143],"lives":[147],"We":[151],"review":[152],"four":[153],"domains":[154,179],"pharmaceutical":[156,227],"research:":[157],"delivery,":[161],"efficacy":[163],"safety,":[165],"pharmacoepidemiology":[166],"policy,":[169],"improved":[171],"access":[172],"drugs.":[177],"These":[178],"encompass":[180],"both":[181],"pre-":[183],"postmarketing":[185,201,235],"phases":[186,209],"research.":[189,236],"Premarketing":[190],"currently":[192],"greater":[194],"magnitude":[195],"infrastructure":[199,233],"research,":[202],"yet":[203],"issues":[204],"arising":[205],"two":[208],"equally":[213],"safety":[219],"A":[223],"national,":[224],"federally":[225],"supported":[226],"database":[228],"could":[229],"greatly":[230],"enhance":[231],"However,":[237],"many":[238],"major":[239],"improvements":[240],"will":[247],"also":[248],"depend":[249],"on":[250],"closing":[251],"gap":[253],"between":[254],"knowledge":[255],"practice":[257],"ability":[261],"manage":[266],"their":[267],"medications.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}