{"id":"https://openalex.org/W2051520155","doi":"https://doi.org/10.1016/s0145-2126(96)00079-3","title":"Interleukin-4 is a pleotropic cytokine with effects on B-cell malignancies","display_name":"Interleukin-4 is a pleotropic cytokine with effects on B-cell malignancies","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2051520155","doi":"https://doi.org/10.1016/s0145-2126(96)00079-3","mag":"2051520155","pmid":"https://pubmed.ncbi.nlm.nih.gov/9029181"},"language":"en","primary_location":{"id":"doi:10.1016/s0145-2126(96)00079-3","doi":"https://doi.org/10.1016/s0145-2126(96)00079-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0145-2126(96)00079-3","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033346506","display_name":"Janice P. Dutcher","orcid":"https://orcid.org/0000-0002-2267-9187","observed_orcids":["https://orcid.org/0000-0002-2267-9187"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice P. Dutcher","raw_affiliation_strings":["Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY 10467, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049972969","display_name":"Usha Venkatraj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Usha Venkatraj","raw_affiliation_strings":["Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, U.S.A","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049425361","display_name":"Della Makower","orcid":"https://orcid.org/0000-0002-8125-2474","observed_orcids":["https://orcid.org/0000-0002-8125-2474"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Della Makower","raw_affiliation_strings":["Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, U.S.A","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I4390039242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089619585","display_name":"Peter H. Wiernik","orcid":"https://orcid.org/0000-0003-1473-813X","observed_orcids":["https://orcid.org/0000-0003-1473-813X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H. Wiernik","raw_affiliation_strings":["Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, U.S.A","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I4390039242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":null,"fwci":0.9216,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.76778889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"1","first_page":"17","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.8417999744415283,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/anti-igm-antibodies","display_name":"anti-IgM antibodies","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/feeder-cells","display_name":"feeder cells","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6478573679924011},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.5974532961845398},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.5790227055549622},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.5435547232627869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5228193998336792},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5165411829948425},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5110043287277222},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.502450704574585},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.49901509284973145},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4622374176979065},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.45981913805007935},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4492017328739166},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.4475187659263611},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44380900263786316},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36875349283218384},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.2453063428401947},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1355271339416504},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.08592277765274048},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.059802085161209106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0145-2126(96)00079-3","doi":"https://doi.org/10.1016/s0145-2126(96)00079-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0145-2126(96)00079-3","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},{"id":"pmid:9029181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9029181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia research","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W176326824","https://openalex.org/W190619870","https://openalex.org/W224069907","https://openalex.org/W1496525513","https://openalex.org/W1591166893","https://openalex.org/W1601600505","https://openalex.org/W1989055057","https://openalex.org/W1991931374","https://openalex.org/W2000246573","https://openalex.org/W2018522670","https://openalex.org/W2023400811","https://openalex.org/W2026538540","https://openalex.org/W2058050336","https://openalex.org/W2061331818","https://openalex.org/W2069611280","https://openalex.org/W2072092290","https://openalex.org/W2080166898","https://openalex.org/W2095433933","https://openalex.org/W2101462909","https://openalex.org/W2117501833","https://openalex.org/W2125753847","https://openalex.org/W2134828784","https://openalex.org/W2158498820","https://openalex.org/W2165644577","https://openalex.org/W2259988458","https://openalex.org/W2415890524","https://openalex.org/W4233112485","https://openalex.org/W6650474693","https://openalex.org/W6674153991"],"related_works":["https://openalex.org/W1983516572","https://openalex.org/W2016939810","https://openalex.org/W176326824","https://openalex.org/W2090620583","https://openalex.org/W2023400811","https://openalex.org/W2057411341","https://openalex.org/W2588162777","https://openalex.org/W8758018","https://openalex.org/W2037480943","https://openalex.org/W2079398199"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}