{"id":"https://openalex.org/W2051475882","doi":"https://doi.org/10.1056/nejmoa020803","title":"Synergistic Polymorphisms of \u03b21- and \u03b12C-Adrenergic Receptors and the Risk of Congestive Heart Failure","display_name":"Synergistic Polymorphisms of \u03b21- and \u03b12C-Adrenergic Receptors and the Risk of Congestive Heart Failure","publication_year":2002,"publication_date":"2002-10-09","ids":{"openalex":"https://openalex.org/W2051475882","doi":"https://doi.org/10.1056/nejmoa020803","mag":"2051475882","pmid":"https://pubmed.ncbi.nlm.nih.gov/12374873"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa020803","doi":"https://doi.org/10.1056/nejmoa020803","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa020803","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060038230","display_name":"Kersten M. Small","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kersten M. Small","raw_affiliation_strings":["Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267-0564, USA","Divisions of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267-0564, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Divisions of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110532264","display_name":"Lynne E. Wagoner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne E. Wagoner","raw_affiliation_strings":["Cardiology, University of Cincinnati College of Medicine, Cincinnati"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, University of Cincinnati College of Medicine, Cincinnati","institution_ids":["https://openalex.org/I63135867","https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087470378","display_name":"Albert M. Levin","orcid":"https://orcid.org/0000-0002-6993-1669","observed_orcids":["https://orcid.org/0000-0002-6993-1669"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert M. Levin","raw_affiliation_strings":["Department of Epidemiology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107536649","display_name":"Sharon L. R. Kardia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon L.R. Kardia","raw_affiliation_strings":["Department of Epidemiology, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033395571","display_name":"Stephen B. Liggett","orcid":"https://orcid.org/0000-0002-0128-3669","observed_orcids":["https://orcid.org/0000-0002-0128-3669"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Liggett","raw_affiliation_strings":["Departments of Medicine and Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati","Divisions of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Divisions of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.6953,"has_fulltext":false,"cited_by_count":528,"citation_normalized_percentile":{"value":0.99760429,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"347","issue":"15","first_page":"1135","last_page":"1142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.426800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.426800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.3086000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.1679999977350235,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.8999999761581421},{"id":"https://openalex.org/keywords/beta1-adrenergic-receptor","display_name":"beta1-adrenergic receptor","score":0.9100000262260437},{"id":"https://openalex.org/keywords/alpha2c-adrenergic-receptor","display_name":"alpha2C-adrenergic receptor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8429999947547913},{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":0.8429999947547913},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.4230000078678131},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.7429999709129333},{"id":"https://openalex.org/keywords/black-patients","display_name":"Black patients","score":0.42899999022483826},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8191555738449097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7384545803070068},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6858442425727844},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6287943124771118},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.5921012759208679},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.574285626411438},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4819171726703644},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.48133930563926697},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4541929364204407},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.44670259952545166},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4419766366481781},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.41870248317718506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19097912311553955},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08711773157119751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018342","descriptor_name":"Receptors, Adrenergic, beta-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmoa020803","doi":"https://doi.org/10.1056/nejmoa020803","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa020803","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:12374873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12374873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G112504381","display_name":null,"funder_award_id":"ES06096","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2733259270","display_name":null,"funder_award_id":"HG00040","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G393493647","display_name":"Center for Environmental Genetics","funder_award_id":"P30ES006096","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4574220777","display_name":null,"funder_award_id":"HL 22619","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G598031191","display_name":null,"funder_award_id":"HL 52318","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6710817820","display_name":"SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE","funder_award_id":"P50HL052318","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7798019519","display_name":"MOLECULAR MECHANISMS OF HEART FAILURE","funder_award_id":"P01HL022619","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W139844472","https://openalex.org/W1959052767","https://openalex.org/W1963531440","https://openalex.org/W1967057789","https://openalex.org/W1973948212","https://openalex.org/W1980153103","https://openalex.org/W1991620824","https://openalex.org/W2019003356","https://openalex.org/W2022363428","https://openalex.org/W2025818505","https://openalex.org/W2038045196","https://openalex.org/W2050822891","https://openalex.org/W2055440970","https://openalex.org/W2061693585","https://openalex.org/W2062225062","https://openalex.org/W2067780051","https://openalex.org/W2080609613","https://openalex.org/W2102192115","https://openalex.org/W2108123330","https://openalex.org/W2116329478","https://openalex.org/W2118201209","https://openalex.org/W2138191190","https://openalex.org/W2141772881","https://openalex.org/W2150562245","https://openalex.org/W2158800467","https://openalex.org/W2161537746","https://openalex.org/W2168667906","https://openalex.org/W2331269392","https://openalex.org/W2339250602","https://openalex.org/W2414869846","https://openalex.org/W2416080279","https://openalex.org/W2519981891"],"related_works":["https://openalex.org/W1980797149","https://openalex.org/W7073578330","https://openalex.org/W1977408705","https://openalex.org/W1964895550","https://openalex.org/W1465742602","https://openalex.org/W2057613750","https://openalex.org/W4241630676","https://openalex.org/W3025036027","https://openalex.org/W2163177527","https://openalex.org/W2101460229"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sustained":[1],"cardiac":[2],"adrenergic":[3],"stimulation":[4],"has":[5,48,59],"been":[6],"implicated":[7],"in":[8,72,97,171,182,219,262],"the":[9,29,32,55,82,112,119,124,133,152,183,217,220,257],"development":[10],"and":[11,28,51,77,103,118,250],"progression":[12],"of":[13,17,31,54,67,115,126,185,222,245,259,276],"heart":[14,88,101,127,138,186,211,260,281],"failure.":[15,89,128],"Release":[16],"norepinephrine":[18,34,75],"is":[19],"controlled":[20],"by":[21],"negative":[22],"feedback":[23],"from":[24,216],"presynaptic":[25],"alpha2-adrenergic":[26],"receptors,":[27],"targets":[30],"released":[33],"on":[35,123],"myocytes":[36],"are":[37],"beta1-adrenergic":[38,56],"receptors.":[39],"In":[40],"transfected":[41],"cells,":[42],"a":[43,52,179,271],"polymorphic":[44],"alpha2C-adrenergic":[45,154],"receptor":[46,57,68,79,155],"(alpha2CDel322-325)":[47],"decreased":[49],"function,":[50],"variant":[53],"(beta1Arg389)":[58],"increased":[60,73],"function.":[61],"We":[62],"hypothesized":[63],"that":[64],"this":[65],"combination":[66],"variants,":[69],"which":[70],"results":[71],"synaptic":[74],"release":[76],"enhanced":[78],"function":[80],"at":[81,92,265,278],"myocyte,":[83],"would":[84],"predispose":[85],"persons":[86,141,189,277],"to":[87,110,164,205,240,255],"METHODS:":[90],"Genotyping":[91,264],"these":[93,266],"loci":[94,268],"was":[95,157,168,178],"performed":[96],"159":[98],"patients":[99,209],"with":[100,149,151,173,210],"failure":[102,139,187,212,261,282],"189":[104],"controls.":[105],"Logistic-regression":[106],"methods":[107],"were":[108,143,191,231,235],"used":[109],"determine":[111],"potential":[113],"effect":[114],"each":[116],"genotype":[117],"interaction":[120],"between":[121],"them":[122],"risk":[125,172,184,258,279],"RESULTS:":[129],"Among":[130,227],"black":[131],"subjects,":[132,229],"adjusted":[134],"odds":[135,197],"ratio":[136],"for":[137,145,193,237,274,280,290],"among":[140,188],"who":[142,190,234,286],"homozygous":[144,192,236],"alpha2CDel322-325":[146,249],"as":[147],"compared":[148],"those":[150],"other":[153],"genotypes":[156],"5.65":[158],"(95":[159],"percent":[160,201],"confidence":[161,202],"interval,":[162,203],"2.67":[163],"11.95;":[165],"P<0.001).":[166],"There":[167],"no":[169],"increase":[170,181,256],"beta1Arg389":[174,251],"alone.":[175],"However,":[176],"there":[177,230],"marked":[180],"both":[194,238],"variants":[195],"(adjusted":[196],"ratio,":[198],"10.11;":[199],"95":[200],"2.11":[204],"48.53;":[206],"P=0.004).":[207],"The":[208,248],"did":[213],"not":[214],"differ":[215],"controls":[218],"frequencies":[221],"nine":[223],"short":[224],"tandem-repeat":[225],"alleles.":[226],"white":[228],"too":[232],"few":[233],"polymorphisms":[239],"allow":[241],"an":[242],"adequate":[243],"assessment":[244],"risk.":[246],"CONCLUSIONS:":[247],"receptors":[252],"act":[253],"synergistically":[254],"blacks.":[263],"two":[267],"may":[269,287],"be":[270,288],"useful":[272],"approach":[273],"identification":[275],"or":[283],"its":[284],"progression,":[285],"candidates":[289],"early":[291],"preventive":[292],"measures.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":28}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
