{"id":"https://openalex.org/W2051470122","doi":"https://doi.org/10.1152/jn.00138.2005","title":"Anticonvulsant Action of GABA in the High Potassium\u2013Low Magnesium Model of Ictogenesis in the Neonatal Rat Hippocampus In Vivo and In Vitro","display_name":"Anticonvulsant Action of GABA in the High Potassium\u2013Low Magnesium Model of Ictogenesis in the Neonatal Rat Hippocampus In Vivo and In Vitro","publication_year":2005,"publication_date":"2005-07-06","ids":{"openalex":"https://openalex.org/W2051470122","doi":"https://doi.org/10.1152/jn.00138.2005","mag":"2051470122","pmid":"https://pubmed.ncbi.nlm.nih.gov/16000527"},"language":"en","primary_location":{"id":"doi:10.1152/jn.00138.2005","doi":"https://doi.org/10.1152/jn.00138.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00138.2005","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000055796","display_name":"Dmytro S. Isaev","orcid":"https://orcid.org/0000-0002-4126-2563","observed_orcids":["https://orcid.org/0000-0002-4126-2563"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmytro Isaev","raw_affiliation_strings":["Section of Neurology, Dartmouth Medical School, Dartmouth-Hitchcock Medical School, Lebanon, NH 03756, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurology, Dartmouth Medical School, Dartmouth-Hitchcock Medical School, Lebanon, NH 03756, USA","institution_ids":["https://openalex.org/I1289422878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083917210","display_name":"Elena Isaeva","orcid":"https://orcid.org/0000-0002-0587-6322","observed_orcids":["https://orcid.org/0000-0002-0587-6322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Isaeva","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048298627","display_name":"Roustem Khazipov","orcid":"https://orcid.org/0000-0002-6763-2841","observed_orcids":["https://orcid.org/0000-0002-6763-2841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rustem Khazipov","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103091290","display_name":"Gregory L. Holmes","orcid":"https://orcid.org/0000-0001-7801-3766","observed_orcids":["https://orcid.org/0000-0001-7801-3766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory L. Holmes","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9248,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.84364927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"94","issue":"4","first_page":"2987","last_page":"2992"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.871999979019165},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neonatal-seizures","display_name":"neonatal seizures","score":0.953000009059906},{"id":"https://openalex.org/keywords/ictogenesis","display_name":"ictogenesis","score":0.847000002861023},{"id":"https://openalex.org/keywords/bicuculline","display_name":"bicuculline","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gabazine","display_name":"gabazine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/isoguvacine","display_name":"isoguvacine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immature-neurons","display_name":"immature neurons","score":0.5709999799728394},{"id":"https://openalex.org/keywords/hippocampal-ca3","display_name":"hippocampal CA3","score":0.8320000171661377},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.7170000076293945},{"id":"https://openalex.org/keywords/excitability","display_name":"excitability","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.8955404758453369},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.6240342259407043},{"id":"https://openalex.org/C79636183","wikidata":"https://www.wikidata.org/wiki/Q5512770","display_name":"GABA receptor antagonist","level":5,"score":0.5905871391296387},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5792307257652283},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.5774366855621338},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.5486364364624023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5204322934150696},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4797755181789398},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.46989771723747253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4380655288696289},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4162070155143738},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4140917956829071},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.2779400944709778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2509117126464844},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18259301781654358},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0730123519897461},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001640","descriptor_name":"Bicuculline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D007539","descriptor_name":"Isonicotinic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015763","descriptor_name":"2-Amino-5-phosphonovalerate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018750","descriptor_name":"6-Cyano-7-nitroquinoxaline-2,3-dione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018755","descriptor_name":"GABA Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jn.00138.2005","doi":"https://doi.org/10.1152/jn.00138.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00138.2005","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmid:16000527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16000527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3203931935","display_name":"LONG TERM EFFECTS OF SEIZURES ON THE DEVELOPING BRAIN","funder_award_id":"R01NS027984","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3796917053","display_name":"Predictors of Seizure-Induced Memory Impairment","funder_award_id":"R01NS044295","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1512180918","https://openalex.org/W1574424799","https://openalex.org/W1575530593","https://openalex.org/W1588629441","https://openalex.org/W1623815617","https://openalex.org/W1914170586","https://openalex.org/W1927501767","https://openalex.org/W1963886933","https://openalex.org/W1963936849","https://openalex.org/W1963992694","https://openalex.org/W1964933128","https://openalex.org/W1967861153","https://openalex.org/W1976416612","https://openalex.org/W1976639286","https://openalex.org/W1977695003","https://openalex.org/W1984499529","https://openalex.org/W1987387089","https://openalex.org/W1988012239","https://openalex.org/W1989758467","https://openalex.org/W2001248841","https://openalex.org/W2001849190","https://openalex.org/W2010778669","https://openalex.org/W2027742741","https://openalex.org/W2029815605","https://openalex.org/W2035006995","https://openalex.org/W2041868953","https://openalex.org/W2046964936","https://openalex.org/W2059097757","https://openalex.org/W2061148748","https://openalex.org/W2064363302","https://openalex.org/W2065813782","https://openalex.org/W2069586118","https://openalex.org/W2079086000","https://openalex.org/W2080726679","https://openalex.org/W2083658603","https://openalex.org/W2094442107","https://openalex.org/W2099711984","https://openalex.org/W2113775152","https://openalex.org/W2117770051","https://openalex.org/W2120278577","https://openalex.org/W2126578880","https://openalex.org/W2150497419","https://openalex.org/W2171558421","https://openalex.org/W2261008854","https://openalex.org/W2418731042","https://openalex.org/W3135190652","https://openalex.org/W4229806422"],"related_works":["https://openalex.org/W2090129014","https://openalex.org/W7100049396","https://openalex.org/W1575530593","https://openalex.org/W2001248841","https://openalex.org/W2161089684","https://openalex.org/W1485943265","https://openalex.org/W7132874529","https://openalex.org/W1979749314","https://openalex.org/W1509724827","https://openalex.org/W7101163461"],"abstract_inverted_index":{"Previous":[0],"developmental":[1,217],"studies":[2,165],"in":[3,47,53,84,88,91,95,108,139,163,190,198,199,202],"vitro":[4,96,164,203],"suggested":[5],"that":[6,21,107,172,178],"the":[7,17,31,43,48,64,78,85,92,98,110,124,131,146,152,191,215],"inhibitory":[8],"neurotransmitter":[9],"GABA":[10,23,46],"exerts":[11],"depolarizing":[12,22],"and":[13,20,90,183,185,201],"excitatory":[14],"actions":[15],"on":[16,42,69],"immature":[18],"neurons":[19],"is":[24,40],"causally":[25],"linked":[26],"to":[27],"ictal":[28,176],"activity":[29,138,177],"during":[30,97,214],"first":[32],"weeks":[33],"of":[34,45,50,66,77,112,119,133,142,145,193,219],"postnatal":[35,100],"life.":[36],"However,":[37],"remarkably":[38],"little":[39],"known":[41],"role":[44],"generation":[49],"neonatal":[51],"seizures":[52,71,196],"vivo.":[54],"Here,":[55],"using":[56,166],"extracellular":[57],"recordings":[58],"from":[59],"CA3":[60],"hippocampus,":[61],"we":[62,169],"studied":[63],"effects":[65],"GABA(A)-acting":[67],"drugs":[68],"electrographic":[70],"induced":[72],"by":[73,117,181,187],"local":[74],"intrahippocampal":[75],"injection":[76],"epileptogenic":[79],"agents":[80],"(high":[81],"K(+)/low":[82],"Mg(2+))":[83],"nonanesthetized":[86],"rats":[87],"vivo":[89,200],"hippocampal":[93,167],"slices":[94],"second":[99],"week":[101],"(postnatal":[102],"days":[103],"P8-12).":[104],"We":[105],"found":[106,171],"vivo,":[109],"induction":[111],"ictal-like":[113,137],"events":[114],"was":[115,179],"facilitated":[116],"co-infusion":[118],"high-K(+)/low":[120,159,173,194],"Mg(2+)":[121,174],"together":[122],"with":[123],"GABA(A)":[125,147,208],"antagonist":[126],"bicuculline":[127,134,182],"or":[128,151],"gabazine.":[129],"Moreover,":[130],"infusion":[132],"alone":[135],"caused":[136],"approximately":[140],"30%":[141],"cases.":[143],"Co-infusion":[144],"receptor":[148],"agonist":[149],"isoguvacine":[150],"GABA(A)-positive":[153],"allosteric":[154],"modulator":[155],"diazepam":[156],"completely":[157],"prevented":[158],"Mg(2+)-induced":[160,195],"seizures.":[161],"In":[162],"slices,":[168],"also":[170],"produced":[175],"exacerbated":[180],"gabazine":[184],"reduced":[186],"isoguvacine.":[188],"Thus":[189],"model":[192],"both":[197],"conditions,":[204],"GABA,":[205],"acting":[206],"via":[207],"receptors,":[209],"has":[210],"an":[211],"anticonvulsant":[212],"effect":[213],"critical":[216],"period":[218],"enhanced":[220],"excitability.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
