{"id":"https://openalex.org/W2051449385","doi":"https://doi.org/10.2147/copd.s48967","title":"Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis","display_name":"Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2051449385","doi":"https://doi.org/10.2147/copd.s48967","mag":"2051449385","pmid":"https://pubmed.ncbi.nlm.nih.gov/24043936","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3772873"},"language":"en","primary_location":{"id":"doi:10.2147/copd.s48967","doi":"https://doi.org/10.2147/copd.s48967","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s48967","pdf_url":"https://www.dovepress.com/getfile.php?fileID=17401","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=17401","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067179752","display_name":"Andreas Karabis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andreas Karabis","raw_affiliation_strings":["MAPI Consultancy, AX Houten, The Netherlands. akarabis@mapigroup.com","MAPI Consultancy, AX Houten, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAPI Consultancy, AX Houten, The Netherlands. akarabis@mapigroup.com","institution_ids":[]},{"raw_affiliation_string":"MAPI Consultancy, AX Houten, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111446488","display_name":"Leandro Lindner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122008","display_name":"Almirall (Spain)","ror":"https://ror.org/03qsven24","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210122008"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Leandro Lindner","raw_affiliation_strings":["Almirall SA, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Almirall SA, Barcelona, Spain","institution_ids":["https://openalex.org/I4210122008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034940111","display_name":"Michelle Mocarski","orcid":"https://orcid.org/0000-0002-8104-8916","observed_orcids":["https://orcid.org/0000-0002-8104-8916"]},"institutions":[{"id":"https://openalex.org/I4391012632","display_name":"Forest Laboratories (United States)","ror":"https://ror.org/01p3wva84","country_code":"US","type":"company","lineage":["https://openalex.org/I4391012632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Mocarski","raw_affiliation_strings":["Health Economics and Outcomes Research, Forest Research Institute, Jersey City, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics and Outcomes Research, Forest Research Institute, Jersey City, NJ, USA","institution_ids":["https://openalex.org/I4391012632"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huisman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huisman","raw_affiliation_strings":["MAPI Consultancy, AX Houten, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAPI Consultancy, AX Houten, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5099941265","display_name":"Greening","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Greening","raw_affiliation_strings":["University of Edinburgh, Lothian University Hospitals' Division, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Lothian University Hospitals' Division, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067179752"],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":1.1794,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.76748868,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"405","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aclidinium-bromide","display_name":"aclidinium bromide","score":0.9179999828338623},{"id":"https://openalex.org/keywords/glycopyrrolate","display_name":"glycopyrrolate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tiotropium","display_name":"tiotropium","score":1.0},{"id":"https://openalex.org/keywords/long-acting-muscarinic-antagonist","display_name":"long-acting muscarinic antagonist","score":0.9229999780654907},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.718999981880188},{"id":"https://openalex.org/keywords/st-george-s-respiratory-questionnaire","display_name":"St George's Respiratory Questionnaire","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.8289999961853027},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.5709999799728394},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.6359999775886536},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.5509999990463257},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.578000009059906},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.5019999742507935},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.5839999914169312},{"id":"https://openalex.org/keywords/copd-hospitalization","display_name":"COPD hospitalization","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C2776968687","wikidata":"https://www.wikidata.org/wiki/Q424316","display_name":"Tiotropium bromide","level":4,"score":0.8385835886001587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8216677904129028},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7897640466690063},{"id":"https://openalex.org/C2776723954","wikidata":"https://www.wikidata.org/wiki/Q3001265","display_name":"Muscarinic antagonist","level":4,"score":0.5206488966941833},{"id":"https://openalex.org/C2780911369","wikidata":"https://www.wikidata.org/wiki/Q753853","display_name":"Lama","level":3,"score":0.499269962310791},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46658068895339966},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4288116693496704},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34185925126075745},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.14563408493995667},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.07485771179199219},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.04259812831878662},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069447","descriptor_name":"Tiotropium Bromide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006024","descriptor_name":"Glycopyrrolate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006024","descriptor_name":"Glycopyrrolate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/copd.s48967","doi":"https://doi.org/10.2147/copd.s48967","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s48967","pdf_url":"https://www.dovepress.com/getfile.php?fileID=17401","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2765993","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3772873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24043936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24043936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of chronic obstructive pulmonary disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3772873","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3772873/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Chron Obstruct Pulmon Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:68b482acbf384e6e9e4bcb24a1e2eb7e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/68b482acbf384e6e9e4bcb24a1e2eb7e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of COPD, Vol 2013, Iss default, Pp 405-423 (2013)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/14290","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/comparative-efficacy-of-aclidinium-versus-glycopyrronium-and-tiotropiu-peer-reviewed-article-COPD","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/copd.s48967","doi":"https://doi.org/10.2147/copd.s48967","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s48967","pdf_url":"https://www.dovepress.com/getfile.php?fileID=17401","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051449385.pdf","grobid_xml":"https://content.openalex.org/works/W2051449385.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1504183466","https://openalex.org/W1517555081","https://openalex.org/W1569625389","https://openalex.org/W1631769030","https://openalex.org/W1704063072","https://openalex.org/W1928394001","https://openalex.org/W1954671479","https://openalex.org/W1967385770","https://openalex.org/W1969836944","https://openalex.org/W1971649226","https://openalex.org/W1980789906","https://openalex.org/W1981197711","https://openalex.org/W2005640821","https://openalex.org/W2029276834","https://openalex.org/W2032446526","https://openalex.org/W2037965009","https://openalex.org/W2048919604","https://openalex.org/W2057765075","https://openalex.org/W2066616351","https://openalex.org/W2070935883","https://openalex.org/W2099757023","https://openalex.org/W2113026917","https://openalex.org/W2113144077","https://openalex.org/W2116894543","https://openalex.org/W2121809065","https://openalex.org/W2125779455","https://openalex.org/W2129929576","https://openalex.org/W2134091333","https://openalex.org/W2134143967","https://openalex.org/W2141034778","https://openalex.org/W2149199480","https://openalex.org/W2149827575","https://openalex.org/W2150866838","https://openalex.org/W2155772830","https://openalex.org/W2171697174","https://openalex.org/W2171974515","https://openalex.org/W2319354361","https://openalex.org/W2328112863","https://openalex.org/W4239080780","https://openalex.org/W4242667311","https://openalex.org/W4246658447","https://openalex.org/W4323053393"],"related_works":["https://openalex.org/W2319354361","https://openalex.org/W2121809065","https://openalex.org/W2129929576","https://openalex.org/W2340398006","https://openalex.org/W1597616964","https://openalex.org/W2077397240","https://openalex.org/W2011096338","https://openalex.org/W2010458287","https://openalex.org/W2068470149","https://openalex.org/W2172492020"],"abstract_inverted_index":{"BACKGROUND:":[0],"Aclidinium":[1,210],"bromide":[2],"is":[3,270],"a":[4,32,130],"new":[5],"long-acting":[6],"muscarinic":[7],"antagonist":[8],"(LAMA)":[9],"indicated":[10],"for":[11,259],"maintenance":[12],"bronchodilator":[13],"treatment":[14,264],"of":[15,23,36,83,103,117,129,281],"chronic":[16],"obstructive":[17],"pulmonary":[18],"disease":[19],"(COPD).":[20],"The":[21,81,123],"efficacy":[22,174],"aclidinium":[24,55,140,171,266],"was":[25,49],"compared":[26,221,285],"with":[27,78,265],"tiotropium":[28,67,72,146,152,176,193,223,238,287,291],"and":[29,101,115,158,202,234,246,283,295],"glycopyrronium,":[30],"using":[31],"network":[33],"meta-analysis":[34],"(NMA)":[35],"randomized":[37],"controlled":[38],"trials":[39],"(RCTs)":[40],"in":[41,76,90,180,212,215,227,254,276],"moderate-to-severe":[42,79],"COPD":[43],"patients.":[44],"METHODS:":[45],"A":[46],"systematic":[47],"review":[48],"performed":[50],"to":[51,175,222,237,272,286],"identify":[52],"RCTs":[53],"evaluating":[54],"400":[56,141,267],"\u03bcg":[57,63,69,74,142,148,154,161,178,195,225,240,268,289,293,298],"twice":[58],"daily":[59,65],"(BID),":[60],"glycopyrronium":[61,159,203,247,296],"50":[62,160,297],"once":[64],"(OD),":[66],"18":[68,153,194,239,292],"OD,":[70],"or":[71],"5":[73,147,177,224,288],"OD":[75,149,155,162],"adults":[77],"COPD.":[80],"outcomes":[82],"interest":[84],"were:":[85],"trough":[86,166],"forced":[87],"expiratory":[88],"volume":[89],"1":[91],"second":[92],"(FEV1);":[93],"St":[94],"George's":[95],"Respiratory":[96],"Questionnaire":[97],"(SGRQ)":[98],"total":[99],"score":[100,114,217,256],"proportion":[102,116],"patients":[104,118],"achieving":[105,119],"\u22654":[106],"unit":[107],"change;":[108],"Transition":[109],"Dyspnea":[110],"Index":[111],"(TDI)":[112],"focal":[113],"\u22651":[120],"point":[121],"change.":[122],"results":[124,236],"were":[125,138,257],"synthesized":[126],"by":[127],"means":[128],"Bayesian":[131],"NMA.":[132],"RESULTS:":[133],"Twenty-one":[134],"studies":[135],"(22,542":[136],"patients)":[137],"included:":[139],"BID":[143,269],"(three":[144,150],"studies);":[145,151,157],"(13":[156],"(two":[163],"studies).":[164],"Regarding":[165],"FEV1":[167],"at":[168,218],"24":[169,219],"weeks,":[170,220],"demonstrated":[172],"comparable":[173,235,258],"(difference":[179,226],"change":[181],"from":[182],"baseline":[183],"[CFB]),":[184],"(0.02":[185,196],"L":[186,197,205],"[95%":[187,198,206,230,242,249],"credible":[188],"interval":[189],"CrI":[190,199,207,231,243,250],"-0.05,":[191,200],"0.09]);":[192],"0.08]);":[201],"(0.00":[204],"-0.07,":[208],"0.07]).":[209],"resulted":[211],"higher":[213],"improvement":[214],"SGRQ":[216],"CFB,":[228],"-2.44":[229],"-4.82,":[232],"-0.05]);":[233],"(-1.80":[241],"-4.52,":[244],"0.14])":[245],"(-1.52":[248],"-4.08,":[251],"1.03]).":[252],"Improvements":[253],"TDI":[255],"all":[260],"treatments.":[261],"CONCLUSION:":[262],"Maintenance":[263],"expected":[271],"produce":[273],"similar":[274],"improvements":[275],"lung":[277],"function,":[278],"health-related":[279],"quality":[280],"life,":[282],"dyspnea":[284],"OD;":[290,294],"OD.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
