{"id":"https://openalex.org/W2051376819","doi":"https://doi.org/10.1002/clc.4960200318","title":"A practical approach to torsade de pointes","display_name":"A practical approach to torsade de pointes","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2051376819","doi":"https://doi.org/10.1002/clc.4960200318","mag":"2051376819","pmid":"https://pubmed.ncbi.nlm.nih.gov/9068917","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6656095"},"language":"en","primary_location":{"id":"doi:10.1002/clc.4960200318","doi":"https://doi.org/10.1002/clc.4960200318","is_oa":true,"landing_page_url":"https://doi.org/10.1002/clc.4960200318","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.4960200318","source":{"id":"https://openalex.org/S82037729","display_name":"Clinical Cardiology","issn_l":"0160-9289","issn":["0160-9289","1932-8737"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cardiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.4960200318","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058141203","display_name":"Dan M. Roden","orcid":"https://orcid.org/0000-0002-6302-0389","observed_orcids":["https://orcid.org/0000-0002-6302-0389"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dan M. Roden","raw_affiliation_strings":["Vanderbilt University School of Medicine, Department of Medicine, Nashville, Tennessee 37232-6602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University School of Medicine, Department of Medicine, Nashville, Tennessee 37232-6602, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058141203"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.2133,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.77326969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"3","first_page":"285","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/torsades-de-pointes","display_name":"torsades de pointes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/polymorphic-ventricular-tachycardia","display_name":"polymorphic ventricular tachycardia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"long QT syndrome","score":0.843999981880188},{"id":"https://openalex.org/keywords/qt-prolonging-drugs","display_name":"QT-prolonging drugs","score":0.9129999876022339},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.9110000133514404},{"id":"https://openalex.org/keywords/acquired-heart-block","display_name":"acquired heart block","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/electrolyte-imbalance","display_name":"electrolyte imbalance","score":0.6919999718666077},{"id":"https://openalex.org/keywords/u-wave","display_name":"U wave","score":0.7440000176429749},{"id":"https://openalex.org/keywords/magnesium-supplementation","display_name":"magnesium supplementation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardiac-pacing","display_name":"cardiac pacing","score":0.8960000276565552},{"id":"https://openalex.org/keywords/antiarrhythmic-therapy","display_name":"antiarrhythmic therapy","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9197632670402527},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.8174147009849548},{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.8067710399627686},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.7539973258972168},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.7306674122810364},{"id":"https://openalex.org/C2780486423","wikidata":"https://www.wikidata.org/wiki/Q1625433","display_name":"Torsades de pointes","level":3,"score":0.5955212712287903},{"id":"https://openalex.org/C2776661526","wikidata":"https://www.wikidata.org/wiki/Q1361515","display_name":"Heart block","level":3,"score":0.5379529595375061},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5316228270530701},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.47753822803497314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46205249428749084},{"id":"https://openalex.org/C2776183862","wikidata":"https://www.wikidata.org/wiki/Q3771629","display_name":"Hypomagnesemia","level":3,"score":0.4481099843978882},{"id":"https://openalex.org/C2988455589","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Cardiac arrhythmia","level":3,"score":0.4187779426574707},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4060652256011963},{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.06221166253089905},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016171","descriptor_name":"Torsades de Pointes","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/clc.4960200318","doi":"https://doi.org/10.1002/clc.4960200318","is_oa":true,"landing_page_url":"https://doi.org/10.1002/clc.4960200318","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.4960200318","source":{"id":"https://openalex.org/S82037729","display_name":"Clinical Cardiology","issn_l":"0160-9289","issn":["0160-9289","1932-8737"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cardiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6656095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6656095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cardiol","raw_type":"Text"},{"id":"pmid:9068917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9068917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cardiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/clc.4960200318","doi":"https://doi.org/10.1002/clc.4960200318","is_oa":true,"landing_page_url":"https://doi.org/10.1002/clc.4960200318","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/clc.4960200318","source":{"id":"https://openalex.org/S82037729","display_name":"Clinical Cardiology","issn_l":"0160-9289","issn":["0160-9289","1932-8737"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051376819.pdf","grobid_xml":"https://content.openalex.org/works/W2051376819.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W116298694","https://openalex.org/W126654122","https://openalex.org/W1232760234","https://openalex.org/W1606576717","https://openalex.org/W1963621879","https://openalex.org/W1966064887","https://openalex.org/W1979924020","https://openalex.org/W1980496173","https://openalex.org/W1990183559","https://openalex.org/W1991662012","https://openalex.org/W2002711428","https://openalex.org/W2003676394","https://openalex.org/W2005411701","https://openalex.org/W2010302358","https://openalex.org/W2012088314","https://openalex.org/W2018841001","https://openalex.org/W2025129838","https://openalex.org/W2030036497","https://openalex.org/W2038031676","https://openalex.org/W2042627773","https://openalex.org/W2047171096","https://openalex.org/W2052085254","https://openalex.org/W2061967268","https://openalex.org/W2062851203","https://openalex.org/W2066138023","https://openalex.org/W2074093573","https://openalex.org/W2074705578","https://openalex.org/W2081517567","https://openalex.org/W2083397218","https://openalex.org/W2083857387","https://openalex.org/W2085873341","https://openalex.org/W2087631949","https://openalex.org/W2092280809","https://openalex.org/W2094601382","https://openalex.org/W2129910735","https://openalex.org/W2144423360","https://openalex.org/W2144520935","https://openalex.org/W2162233259","https://openalex.org/W2165135845","https://openalex.org/W2284531888","https://openalex.org/W2471757827","https://openalex.org/W4232353715","https://openalex.org/W4285719527","https://openalex.org/W6669904975"],"related_works":["https://openalex.org/W2156951322","https://openalex.org/W2007042571","https://openalex.org/W49759782","https://openalex.org/W2061967268","https://openalex.org/W2154025234","https://openalex.org/W2071956483","https://openalex.org/W2400455312","https://openalex.org/W2091425082","https://openalex.org/W4245869374","https://openalex.org/W2042708431"],"abstract_inverted_index":{"The":[0,74],"term":[1],"torsade":[2,32,63,78,123],"de":[3,33,64,79,124],"pointes":[4,34,80],"refers":[5],"to":[6],"polymorphic":[7],"ventricular":[8],"tachycardia":[9],"that":[10,61],"occurs":[11,36],"in":[12,37,44,122],"the":[13,22,38,45,93,100],"setting":[14,46],"of":[15,47,77,92,97,99,103,109],"an":[16],"abnormally":[17],"long":[18,40],"QT":[19,29,41,58,83],"interval.":[20],"While":[21],"most":[23],"common":[24],"cause":[25,62],"is":[26],"treatment":[27],"with":[28],"prolonging":[30,59],"drugs,":[31],"also":[35],"congenital":[39],"syndromes":[42],"and":[43,68,88,107],"acquired":[48],"heart":[49],"block":[50],"or":[51,115],"severe":[52],"electrolyte":[53,105],"disturbance,":[54],"notably":[55],"hypokalemia.":[56],"Among":[57],"drugs":[60,70],"pointes,":[65],"both":[66],"antiarrhythmics":[67],"\"noncardioactive\"":[69],"have":[71],"been":[72],"recognized.":[73],"electrocardiographic":[75],"features":[76],"include":[81],"labile":[82],"intervals,":[84],"prominent":[85],"U":[86],"waves,":[87],"a":[89],"\"pause-dependent\"":[90],"onset":[91],"arrhythmia.":[94],"Treatment":[95],"consists":[96],"recognition":[98],"syndrome,":[101],"correction":[102],"underlying":[104],"abnormalities,":[106],"withdrawal":[108],"any":[110],"offending":[111],"drugs.":[112],"Magnesium,":[113],"isoproterenol,":[114],"cardiac":[116],"pacing":[117],"provides":[118],"specific":[119],"antiarrhythmic":[120],"therapy":[121],"pointes.":[125]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}