{"id":"https://openalex.org/W2051363723","doi":"https://doi.org/10.3109/10520295.2012.730153","title":"MicroRNAs as potential clinical biomarkers: emerging approaches for their detection","display_name":"MicroRNAs as potential clinical biomarkers: emerging approaches for their detection","publication_year":2013,"publication_date":"2013-01-07","ids":{"openalex":"https://openalex.org/W2051363723","doi":"https://doi.org/10.3109/10520295.2012.730153","mag":"2051363723","pmid":"https://pubmed.ncbi.nlm.nih.gov/23293934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318494"},"language":"en","primary_location":{"id":"doi:10.3109/10520295.2012.730153","doi":"https://doi.org/10.3109/10520295.2012.730153","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10520295.2012.730153","pdf_url":null,"source":{"id":"https://openalex.org/S167033782","display_name":"Biotechnic & Histochemistry","issn_l":"1052-0295","issn":["1052-0295","1473-7760"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnic &amp; Histochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103421828","display_name":"SK Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SK Srivastava","raw_affiliation_strings":["Mitchell Cancer Institute, University of South Alabama, Mobile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Bhardwaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Bhardwaj","raw_affiliation_strings":["Mitchell Cancer Institute, University of South Alabama, Mobile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032098701","display_name":"Silas J. Leavesley","orcid":"https://orcid.org/0000-0002-2684-9534","observed_orcids":["https://orcid.org/0000-0002-2684-9534"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SJ Leavesley","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of South Alabama, Mobile; Department of Pharmacology, University of South Alabama, Mobile","Department of Chemical and Biomolecular Engineering, University of South Alabama, Mobile","Department of Pharmacology, University of South Alabama, Mobile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of South Alabama, Mobile; Department of Pharmacology, University of South Alabama, Mobile","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of South Alabama, Mobile","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Pharmacology, University of South Alabama, Mobile","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111802095","display_name":"William E Grizzle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WE Grizzle","raw_affiliation_strings":["Department of Pathology, University of Alabama at Birmingham, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Alabama at Birmingham, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090913410","display_name":"Seema Singh","orcid":"https://orcid.org/0000-0002-6985-6304","observed_orcids":["https://orcid.org/0000-0002-6985-6304"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Singh","raw_affiliation_strings":["Mitchell Cancer Institute, University of South Alabama, Mobile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109974898","display_name":"AP Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089171","display_name":"USA Mitchell Cancer Institute","ror":"https://ror.org/009wx7055","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210089171"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"AP Singh","raw_affiliation_strings":["Mitchell Cancer Institute, University of South Alabama, Mobile; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama","Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama","Mitchell Cancer Institute, University of South Alabama, Mobile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama","institution_ids":["https://openalex.org/I4210089171","https://openalex.org/I83809506"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"Mitchell Cancer Institute, University of South Alabama, Mobile","institution_ids":["https://openalex.org/I83809506"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109974898"],"corresponding_institution_ids":["https://openalex.org/I4210089171","https://openalex.org/I83809506"],"apc_list":null,"apc_paid":null,"fwci":1.2092,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.77301763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"88","issue":"7","first_page":"373","last_page":"387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clinical-biomarkers","display_name":"clinical biomarkers","score":0.9570000171661377},{"id":"https://openalex.org/keywords/microrna-detection","display_name":"microRNA detection","score":0.9620000123977661},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9010000228881836},{"id":"https://openalex.org/keywords/disease-biomarkers","display_name":"disease biomarkers","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8222875595092773},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6091293692588806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5320642590522766},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.43912386894226074},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3876543343067169},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3764793872833252},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3026488721370697},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16402274370193481}],"mesh":[{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3109/10520295.2012.730153","doi":"https://doi.org/10.3109/10520295.2012.730153","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10520295.2012.730153","pdf_url":null,"source":{"id":"https://openalex.org/S167033782","display_name":"Biotechnic & Histochemistry","issn_l":"1052-0295","issn":["1052-0295","1473-7760"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnic &amp; Histochemistry","raw_type":"journal-article"},{"id":"pmid:23293934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23293934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnic & histochemistry : official publication of the Biological Stain Commission","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3285654","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4318494","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318494","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biotech Histochem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3285654","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4579347369","display_name":"MicroRNAs in Pancreatic Cancer","funder_award_id":"R03CA137513","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W76973823","https://openalex.org/W94815550","https://openalex.org/W410897752","https://openalex.org/W1501209648","https://openalex.org/W1506361183","https://openalex.org/W1510389712","https://openalex.org/W1827605648","https://openalex.org/W1856793913","https://openalex.org/W1966101011","https://openalex.org/W1969234199","https://openalex.org/W1970744845","https://openalex.org/W1974976948","https://openalex.org/W1976033874","https://openalex.org/W1981186391","https://openalex.org/W1987464992","https://openalex.org/W1992833797","https://openalex.org/W1994248946","https://openalex.org/W2001893591","https://openalex.org/W2001911979","https://openalex.org/W2006002715","https://openalex.org/W2006426795","https://openalex.org/W2008264883","https://openalex.org/W2013990977","https://openalex.org/W2014610388","https://openalex.org/W2015893546","https://openalex.org/W2016987986","https://openalex.org/W2017482485","https://openalex.org/W2026531690","https://openalex.org/W2038044288","https://openalex.org/W2038054133","https://openalex.org/W2039108801","https://openalex.org/W2041945875","https://openalex.org/W2043691265","https://openalex.org/W2045231861","https://openalex.org/W2049895095","https://openalex.org/W2051403674","https://openalex.org/W2059355832","https://openalex.org/W2060037353","https://openalex.org/W2063770678","https://openalex.org/W2066531961","https://openalex.org/W2067193961","https://openalex.org/W2069394393","https://openalex.org/W2079251691","https://openalex.org/W2080413361","https://openalex.org/W2080562735","https://openalex.org/W2080808874","https://openalex.org/W2081693241","https://openalex.org/W2083381199","https://openalex.org/W2083634954","https://openalex.org/W2086263373","https://openalex.org/W2090219560","https://openalex.org/W2096304780","https://openalex.org/W2098777824","https://openalex.org/W2103427526","https://openalex.org/W2104146201","https://openalex.org/W2113150125","https://openalex.org/W2115093090","https://openalex.org/W2117420531","https://openalex.org/W2120294133","https://openalex.org/W2120785986","https://openalex.org/W2121422066","https://openalex.org/W2126102214","https://openalex.org/W2126696654","https://openalex.org/W2127669794","https://openalex.org/W2129615821","https://openalex.org/W2130517519","https://openalex.org/W2130979840","https://openalex.org/W2131118100","https://openalex.org/W2133478942","https://openalex.org/W2135613885","https://openalex.org/W2137665434","https://openalex.org/W2139471389","https://openalex.org/W2139992910","https://openalex.org/W2141619720","https://openalex.org/W2142877629","https://openalex.org/W2147297308","https://openalex.org/W2152558372","https://openalex.org/W2154909423","https://openalex.org/W2157155706","https://openalex.org/W2158878989","https://openalex.org/W2161222316","https://openalex.org/W2162489334","https://openalex.org/W2164745666","https://openalex.org/W2171201030","https://openalex.org/W2211700441","https://openalex.org/W2318596848","https://openalex.org/W2318624961","https://openalex.org/W2470224098","https://openalex.org/W3142567747","https://openalex.org/W4231558498","https://openalex.org/W4249313862"],"related_works":["https://openalex.org/W4286599507","https://openalex.org/W2499544248","https://openalex.org/W1973102533","https://openalex.org/W1987670809","https://openalex.org/W2547843831","https://openalex.org/W4302028729","https://openalex.org/W4401355517","https://openalex.org/W2095727420","https://openalex.org/W2105679485","https://openalex.org/W4317778630"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"have":[2],"emerged":[3],"as":[4,35],"novel":[5],"post-transcriptional":[6],"regulators":[7],"of":[8,38,65,68],"gene":[9],"expression.":[10],"These":[11],"short":[12],"non-coding":[13],"RNAs":[14],"are":[15,46],"involved":[16],"in":[17],"diverse":[18],"biological":[19],"processes":[20],"and":[21,40,43,59,63,71],"their":[22,53],"dysregulation":[23],"is":[24],"often":[25],"observed":[26],"under":[27],"diseased":[28],"conditions.":[29],"Therefore,":[30],"miRNAs":[31],"hold":[32],"great":[33],"potential":[34],"clinical":[36],"biomarkers":[37],"physiological":[39],"pathological":[41],"states":[42],"extensive":[44],"efforts":[45],"underway":[47],"to":[48],"develop":[49],"efficient":[50],"approaches":[51],"for":[52],"detection.":[54,72],"We":[55],"review":[56],"recent":[57],"advances":[58],"discuss":[60],"the":[61],"promises":[62],"pitfalls":[64],"emerging":[66],"methods":[67],"miRNA":[69],"profiling":[70]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
