{"id":"https://openalex.org/W2051362893","doi":"https://doi.org/10.1016/j.juro.2011.02.364","title":"272 NEUROPEPTIDES PROMOTE CASTRATION RESISTANT PROSTATE CANCER THROUGH INTRACRINE ANDROGEN BIOSYNTHESIS","display_name":"272 NEUROPEPTIDES PROMOTE CASTRATION RESISTANT PROSTATE CANCER THROUGH INTRACRINE ANDROGEN BIOSYNTHESIS","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2051362893","doi":"https://doi.org/10.1016/j.juro.2011.02.364","mag":"2051362893"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2011.02.364","doi":"https://doi.org/10.1016/j.juro.2011.02.364","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2011.02.364","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061399768","display_name":"C. Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Evans","raw_affiliation_strings":["Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sacramento, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086066594","display_name":"Joy C. Yang","orcid":"https://orcid.org/0000-0001-9162-481X","observed_orcids":["https://orcid.org/0000-0001-9162-481X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joy Yang","raw_affiliation_strings":["Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sacramento, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114209677","display_name":"Hsing\u2010Jien Kung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hsing-Jien Kung","raw_affiliation_strings":["Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sacramento, CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048369552","display_name":"Allen C. Gao","orcid":"https://orcid.org/0000-0002-5966-9038","observed_orcids":["https://orcid.org/0000-0002-5966-9038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allen Gao","raw_affiliation_strings":["Sacramento, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sacramento, CA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17932925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"185","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/neuroendocrine-prostate-cancer","display_name":"neuroendocrine prostate cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gastrin-releasing-peptide","display_name":"gastrin-releasing peptide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/akr1c3","display_name":"AKR1C3","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cyp17a1","display_name":"CYP17A1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hsd17b2","display_name":"HSD17B2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.7540000081062317},{"id":"https://openalex.org/keywords/saracatinib","display_name":"saracatinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chromogranin-a","display_name":"chromogranin A","score":0.824999988079071},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C63263939","wikidata":"https://www.wikidata.org/wiki/Q3153691","display_name":"Intracrine","level":4,"score":0.9775367975234985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8591389656066895},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6600964069366455},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5575963854789734},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5380292534828186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47921139001846313},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4689257740974426},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.4539291262626648},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4362519085407257},{"id":"https://openalex.org/C2779256933","wikidata":"https://www.wikidata.org/wiki/Q58929","display_name":"Castration","level":3,"score":0.42691904306411743},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41545504331588745},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2793482840061188},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.15156841278076172},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12605392932891846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2011.02.364","doi":"https://doi.org/10.1016/j.juro.2011.02.364","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2011.02.364","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2325457613","https://openalex.org/W2322551357","https://openalex.org/W3135518982","https://openalex.org/W2120097451","https://openalex.org/W2152315862","https://openalex.org/W2079789193","https://openalex.org/W3013298158","https://openalex.org/W2760543045","https://openalex.org/W2792582775","https://openalex.org/W2037219617"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,102,150,160,163,226,262,349,355],"UrologyProstate":[4],"Cancer:":[5],"Basic":[6],"Research1":[7],"Apr":[8],"2011272":[9],"NEUROPEPTIDES":[10],"PROMOTE":[11],"CASTRATION":[12],"RESISTANT":[13],"PROSTATE":[14],"CANCER":[15],"THROUGH":[16],"INTRACRINE":[17],"ANDROGEN":[18],"BIOSYNTHESIS":[19],"Chris":[20,29,405],"Evans,":[21],"Joy":[22,40,414],"Yang,":[23],"Hsing-Jien":[24,51,423],"Kung,":[25],"and":[26,62,146,156,181,194,209,230,252,265,273,282,302,321,342,379,400],"Allen":[27,63,432],"Gao":[28,65,433],"EvansChris":[30],"Evans":[31,406],"Sacramento,":[32,43,54,66,407,416,425,434],"CA":[33,44,55,67,408,417,426,435],"More":[34,45,56,68,409,418,427,436],"articles":[35,46,57,69,410,419,428,437],"by":[36,47,58,70,132,154,221,294,374,395,411,420,429,438],"this":[37,48,59,71,412,421,430,439],"author":[38,49,60,72,413,422,431,440],",":[39,50,61,310],"YangJoy":[41],"Yang":[42,415],"KungHsing-Jien":[52],"Kung":[53,424],"GaoAllen":[64],"View":[73],"All":[74,442],"Author":[75,403],"Informationhttps://doi.org/10.1016/j.juro.2011.02.364AboutPDF":[76],"ToolsAdd":[77],"to":[78,115,170,217,338],"favoritesDownload":[79],"CitationsTrack":[80],"CitationsPermissionsReprints":[81],"ShareFacebookTwitterLinked":[82],"InEmail":[83],"INTRODUCTION":[84],"AND":[85],"OBJECTIVES":[86],"Neuroendocrine":[87],"differentiation":[88],"is":[89],"associated":[90],"with":[91,97,168,174,206,278,336],"castration":[92],"resistant":[93],"prostate":[94],"cancer":[95],"(CRPC)":[96],"detectable":[98,293],"increased":[99],"serum":[100,190,311,341],"levels":[101,184,330],"chromogranin":[103],"A":[104],"in":[105,120,187,203,236,250,255,267,297,308,370],"patients.":[106],"Neuropeptides":[107],"secreted":[108],"from":[109,191,312],"the":[110,148,218,260],"neuroendocrine":[111],"cells":[112,141,165,269],"are":[113],"believed":[114],"activate":[116],"androgen":[117,124,135,151,198,357],"receptor":[118],"(AR)":[119],"low":[121],"or":[122,172,175],"no":[123],"environments.":[125],"We":[126,138],"hypothesize":[127],"that":[128],"neuropeptides":[129,350],"sustain":[130],"CRPC":[131,352],"promoting":[133],"intracrine":[134,356],"synthesis.":[136],"METHODS":[137],"engineered":[139],"LNCaP":[140],"overexpressing":[142],"gastrin-releasing":[143],"peptide":[144],"(GRP)":[145],"examined":[147],"level":[149],"biosynthetic":[152,199],"enzymes":[153,200],"RT-PCR":[155,223],"Western":[157],"blots.":[158],"Inhibition":[159],"androgen-free":[161],"growth":[162,235,249],"LNCaP-GRP":[164,188,204,233,247,288,298],"was":[166,292],"performed":[167],"siRNA":[169,227,279],"AKR1C3":[171,229,281],"CYP17A1":[173,208,231],"without":[176],"Src":[177,240],"inhibitor":[178,243],"saracatinib.":[179],"PSA":[180],"total":[182],"testosterone":[183],"were":[185,201,331],"assessed":[186],"cells,":[189,205],"tumor-bearing":[192],"animals":[193],"xenografts.":[195],"RESULTS":[196],"The":[197],"up-regulated":[202],"AKR1C3,":[207,263],"HSD17B2":[210],"displaying":[211],"over":[212],"40":[213],"fold":[214],"increase":[215],"compared":[216],"control":[219],"line":[220],"real-time":[222],"analysis.":[224],"Transfection":[225],"against":[228],"inhibited":[232,286],"cell":[234,248,289,299],"androgen\u2014free":[237],"medium.":[238],"Specific":[239],"family":[241],"kinase":[242],"saracatinib":[244,284],"inhibits":[245],"androgen-independent":[246,287],"vitro":[251],"tumor":[253],"metastasis":[254],"vivo.":[256],"Saracatinib":[257,359],"also":[258,367],"reduced":[259,333],"expression":[261],"AKR1C1/2":[264],"HSD3B1/2":[266],"GRP":[268,316],"at":[270],"both":[271],"RNA":[272],"protein":[274,305],"levels.":[275],"When":[276],"combined":[277],"for":[280],"CYP17A1,":[283],"further":[285],"growth.":[290],"Testosterone":[291],"EIA":[295],"assay":[296],"lysates":[300],"(109.1":[301],"44.5":[303],"pg/mg":[304,325,344],"vs.":[306],"18.3":[307],"control)":[309],"castrated":[313],"mice":[314],"bearing":[315],"tumors":[317],"(2235.5":[318],"pg/ml":[319,340],"serum)":[320],"xenograft":[322],"tissue":[323],"(59.2":[324],"tumor).":[326],"These":[327],"enhanced":[328],"T":[329],"greatly":[332],"when":[334],"treated":[335],"saracatinib,":[337],"594":[339],"12":[343],"tumor,":[345],"respectively.":[346],"CONCLUSIONS":[347],"Secretion":[348],"promotes":[351],"through":[353],"up-regulation":[354],"biosynthesis.":[358],"not":[360],"only":[361],"targets":[362],"neuropeptide-mediated":[363],"AR":[364],"activation":[365],"but":[366],"blocks":[368],"steroidogenesis":[369],"CRPC.":[371],"\u00a9":[372],"2011":[373,387,394],"American":[375,396],"Urological":[376,397],"Association":[377,398],"Education":[378,399],"Research,":[380,401],"Inc.FiguresReferencesRelatedDetails":[381],"Volume":[382],"185":[383],"Issue":[384],"4S":[385],"April":[386],"Page:":[388],"e109":[389],"Advertisement":[390,443,444],"Copyright":[391],"&":[392],"Permissions\u00a9":[393],"Inc.Metrics":[402],"Information":[404],"Expand":[441],"PDF":[445],"downloadLoading":[446],"...":[447]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}