{"id":"https://openalex.org/W2051296872","doi":"https://doi.org/10.1126/science.1957167","title":"Chromosome Aberrations and Cancer","display_name":"Chromosome Aberrations and Cancer","publication_year":1991,"publication_date":"1991-11-22","ids":{"openalex":"https://openalex.org/W2051296872","doi":"https://doi.org/10.1126/science.1957167","mag":"2051296872","pmid":"https://pubmed.ncbi.nlm.nih.gov/1957167"},"language":"en","primary_location":{"id":"doi:10.1126/science.1957167","doi":"https://doi.org/10.1126/science.1957167","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1957167","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2051296872"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109108911","display_name":"Ellen Solomon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen Solomon","raw_affiliation_strings":["Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054785349","display_name":"Julian Borrow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julian Borrow","raw_affiliation_strings":["Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110039863","display_name":"Audrey D. Goddard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audrey D. Goddard","raw_affiliation_strings":["Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.9967,"has_fulltext":false,"cited_by_count":588,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"254","issue":"5035","first_page":"1153","last_page":"1160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.07100000232458115,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":1.0},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7020000219345093},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7166260480880737},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.69465172290802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6364367008209229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6012538075447083},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5544806122779846},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5270545482635498},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.519168496131897},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5111408829689026},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4712006747722626},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.46875715255737305},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.45935678482055664},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.44891977310180664},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.43506503105163574},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17876514792442322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15556254982948303},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002872","descriptor_name":"Chromosome Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1957167","doi":"https://doi.org/10.1126/science.1957167","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1957167","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:1957167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1957167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":222,"referenced_works":["https://openalex.org/W2340105","https://openalex.org/W85984135","https://openalex.org/W93821329","https://openalex.org/W243482386","https://openalex.org/W334015312","https://openalex.org/W938751941","https://openalex.org/W1482882106","https://openalex.org/W1485447614","https://openalex.org/W1510546584","https://openalex.org/W1544439137","https://openalex.org/W1553992864","https://openalex.org/W1575638464","https://openalex.org/W1580535447","https://openalex.org/W1584049223","https://openalex.org/W1598175600","https://openalex.org/W1602193081","https://openalex.org/W1685865647","https://openalex.org/W1785785106","https://openalex.org/W1906167831","https://openalex.org/W1910167124","https://openalex.org/W1955257539","https://openalex.org/W1963932371","https://openalex.org/W1964362980","https://openalex.org/W1964382251","https://openalex.org/W1964619416","https://openalex.org/W1964896385","https://openalex.org/W1965388358","https://openalex.org/W1966746821","https://openalex.org/W1967354499","https://openalex.org/W1967392052","https://openalex.org/W1967457118","https://openalex.org/W1967861547","https://openalex.org/W1970067962","https://openalex.org/W1970754922","https://openalex.org/W1971602793","https://openalex.org/W1971874426","https://openalex.org/W1972251449","https://openalex.org/W1972642770","https://openalex.org/W1972651910","https://openalex.org/W1972804480","https://openalex.org/W1973071934","https://openalex.org/W1974839297","https://openalex.org/W1974870158","https://openalex.org/W1975993620","https://openalex.org/W1977289089","https://openalex.org/W1977362601","https://openalex.org/W1977895957","https://openalex.org/W1978130054","https://openalex.org/W1978313777","https://openalex.org/W1979618971","https://openalex.org/W1980847511","https://openalex.org/W1981044274","https://openalex.org/W1982361487","https://openalex.org/W1985715657","https://openalex.org/W1987234748","https://openalex.org/W1987979676","https://openalex.org/W1988288968","https://openalex.org/W1989950905","https://openalex.org/W1989976890","https://openalex.org/W1990280589","https://openalex.org/W1990903254","https://openalex.org/W1991615434","https://openalex.org/W1991959991","https://openalex.org/W1991962475","https://openalex.org/W1992178795","https://openalex.org/W1992689578","https://openalex.org/W1992891334","https://openalex.org/W1993657586","https://openalex.org/W1993951035","https://openalex.org/W1994082723","https://openalex.org/W1994559762","https://openalex.org/W1995647596","https://openalex.org/W1996449685","https://openalex.org/W1997858969","https://openalex.org/W1997936885","https://openalex.org/W1998562271","https://openalex.org/W1998593414","https://openalex.org/W1999197294","https://openalex.org/W1999200731","https://openalex.org/W2001502532","https://openalex.org/W2001957428","https://openalex.org/W2007397727","https://openalex.org/W2007684414","https://openalex.org/W2009263545","https://openalex.org/W2010184646","https://openalex.org/W2010965145","https://openalex.org/W2012675202","https://openalex.org/W2015828720","https://openalex.org/W2016136975","https://openalex.org/W2016228336","https://openalex.org/W2016575124","https://openalex.org/W2018527149","https://openalex.org/W2019215987","https://openalex.org/W2021457118","https://openalex.org/W2022081023","https://openalex.org/W2022668368","https://openalex.org/W2023905569","https://openalex.org/W2024187144","https://openalex.org/W2024280594","https://openalex.org/W2024378792","https://openalex.org/W2026853588","https://openalex.org/W2028193011","https://openalex.org/W2028937947","https://openalex.org/W2030480699","https://openalex.org/W2031435888","https://openalex.org/W2031760182","https://openalex.org/W2032191237","https://openalex.org/W2032631136","https://openalex.org/W2034768144","https://openalex.org/W2035454745","https://openalex.org/W2037068816","https://openalex.org/W2037592881","https://openalex.org/W2037749822","https://openalex.org/W2038664988","https://openalex.org/W2038845041","https://openalex.org/W2041767226","https://openalex.org/W2041792131","https://openalex.org/W2043002046","https://openalex.org/W2043637408","https://openalex.org/W2046302025","https://openalex.org/W2046512279","https://openalex.org/W2050885661","https://openalex.org/W2052207224","https://openalex.org/W2055268829","https://openalex.org/W2056328047","https://openalex.org/W2056987652","https://openalex.org/W2057257609","https://openalex.org/W2057269176","https://openalex.org/W2058111504","https://openalex.org/W2058392986","https://openalex.org/W2059766103","https://openalex.org/W2059813946","https://openalex.org/W2060865001","https://openalex.org/W2061318624","https://openalex.org/W2061656021","https://openalex.org/W2062181868","https://openalex.org/W2063083122","https://openalex.org/W2063602321","https://openalex.org/W2064618550","https://openalex.org/W2066328877","https://openalex.org/W2069297502","https://openalex.org/W2069349857","https://openalex.org/W2069484302","https://openalex.org/W2070080134","https://openalex.org/W2070168194","https://openalex.org/W2071151376","https://openalex.org/W2071893342","https://openalex.org/W2072973893","https://openalex.org/W2074114480","https://openalex.org/W2075300416","https://openalex.org/W2076372887","https://openalex.org/W2077858999","https://openalex.org/W2081491684","https://openalex.org/W2081837269","https://openalex.org/W2081923886","https://openalex.org/W2082030057","https://openalex.org/W2083193857","https://openalex.org/W2083801462","https://openalex.org/W2085226130","https://openalex.org/W2086604490","https://openalex.org/W2088245458","https://openalex.org/W2088692721","https://openalex.org/W2088706525","https://openalex.org/W2090331818","https://openalex.org/W2091349362","https://openalex.org/W2091723114","https://openalex.org/W2091830776","https://openalex.org/W2092691551","https://openalex.org/W2095156669","https://openalex.org/W2095632290","https://openalex.org/W2097694896","https://openalex.org/W2099742439","https://openalex.org/W2108574775","https://openalex.org/W2111936872","https://openalex.org/W2115073099","https://openalex.org/W2115524556","https://openalex.org/W2128508005","https://openalex.org/W2137256876","https://openalex.org/W2141393790","https://openalex.org/W2143444317","https://openalex.org/W2147650665","https://openalex.org/W2148018436","https://openalex.org/W2148069086","https://openalex.org/W2151067616","https://openalex.org/W2152960246","https://openalex.org/W2155114227","https://openalex.org/W2158510547","https://openalex.org/W2161410968","https://openalex.org/W2163292634","https://openalex.org/W2163997831","https://openalex.org/W2165696859","https://openalex.org/W2165872934","https://openalex.org/W2195957924","https://openalex.org/W2221403975","https://openalex.org/W2274425924","https://openalex.org/W2330923897","https://openalex.org/W2336558447","https://openalex.org/W2337510086","https://openalex.org/W2339475636","https://openalex.org/W2398201704","https://openalex.org/W2402916230","https://openalex.org/W2403655252","https://openalex.org/W2407900052","https://openalex.org/W2408012802","https://openalex.org/W2409184083","https://openalex.org/W2410018419","https://openalex.org/W2410200490","https://openalex.org/W2411149624","https://openalex.org/W2412239933","https://openalex.org/W2412765267","https://openalex.org/W2412806286","https://openalex.org/W2413743311","https://openalex.org/W2415570531","https://openalex.org/W2417639101","https://openalex.org/W2423858046","https://openalex.org/W2465895714","https://openalex.org/W2615426026","https://openalex.org/W3027033617","https://openalex.org/W3027774462","https://openalex.org/W3114112552","https://openalex.org/W4248142848","https://openalex.org/W4254570111"],"related_works":["https://openalex.org/W4243543826","https://openalex.org/W2011130572","https://openalex.org/W4241040781","https://openalex.org/W2625094852","https://openalex.org/W4388299040","https://openalex.org/W2470478683","https://openalex.org/W1034366581","https://openalex.org/W2195957924","https://openalex.org/W2423579092","https://openalex.org/W2409842193"],"abstract_inverted_index":{"Cancer":[0],"may":[1],"be":[2],"defined":[3],"as":[4],"a":[5,14,23,98],"progressive":[6],"series":[7],"of":[8,17,20,26,37,44,51,53,59,62,87,103],"genetic":[9],"events":[10],"that":[11],"occur":[12],"in":[13,22,71,77],"single":[15],"clone":[16],"cells":[18],"because":[19],"alterations":[21],"limited":[24],"number":[25],"specific":[27],"genes:":[28],"the":[29,49,57,78],"oncogenes":[30],"and":[31,56,83],"tumor":[32,73],"suppressor":[33],"genes.":[34],"The":[35],"association":[36],"consistent":[38],"chromosome":[39,65],"aberrations":[40,66],"with":[41],"particular":[42],"types":[43,74],"cancer":[45],"has":[46],"led":[47],"to":[48,97],"identification":[50],"some":[52],"these":[54],"genes":[55,90],"elucidation":[58],"their":[60],"mechanisms":[61],"action.":[63],"Consistent":[64],"are":[67],"observed":[68],"not":[69],"only":[70],"rare":[72],"but":[75],"also":[76],"relatively":[79],"common":[80],"lung,":[81],"colon,":[82],"breast":[84],"cancers.":[85],"Identification":[86],"additional":[88],"mutated":[89],"through":[91],"other":[92],"chromosomal":[93],"abnormalities":[94],"will":[95],"lead":[96],"more":[99],"complete":[100],"molecular":[101],"description":[102],"oncogenesis.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}