{"id":"https://openalex.org/W2051293481","doi":"https://doi.org/10.1200/jco.2003.06.177","title":"Metachronous Skeletal Osteosarcoma in Patients Treated with Adjuvant and Neoadjuvant Chemotherapy for Nonmetastatic Osteosarcoma","display_name":"Metachronous Skeletal Osteosarcoma in Patients Treated with Adjuvant and Neoadjuvant Chemotherapy for Nonmetastatic Osteosarcoma","publication_year":2003,"publication_date":"2003-01-13","ids":{"openalex":"https://openalex.org/W2051293481","doi":"https://doi.org/10.1200/jco.2003.06.177","mag":"2051293481","pmid":"https://pubmed.ncbi.nlm.nih.gov/12525528"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2003.06.177","doi":"https://doi.org/10.1200/jco.2003.06.177","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2003.06.177","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110001047","display_name":"LeLe Aung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LeLe Aung","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032743242","display_name":"Richard Greg Gorlick","orcid":"https://orcid.org/0000-0001-8995-2929","observed_orcids":["https://orcid.org/0000-0001-8995-2929"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Gorlick","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022207361","display_name":"John H. Healey","orcid":"https://orcid.org/0000-0002-0802-1186","observed_orcids":["https://orcid.org/0000-0002-0802-1186"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Healey","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652591","display_name":"Weiji Shi","orcid":"https://orcid.org/0000-0001-5595-0028","observed_orcids":["https://orcid.org/0000-0001-5595-0028"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiji Shi","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110311181","display_name":"Howard T. Thaler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard T. Thaler","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030966215","display_name":"Nicholas A. Shorter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A. Shorter","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017081282","display_name":"Andrew G. Huvos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew G. Huvos","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010913859","display_name":"Paul A. Meyers","orcid":"https://orcid.org/0000-0001-6146-6101","observed_orcids":["https://orcid.org/0000-0001-6146-6101"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Meyers","raw_affiliation_strings":["From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics, Department of Surgery, Department of Biostatistics, and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":2.1605,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.87061669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"21","issue":"2","first_page":"342","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":1.0},{"id":"https://openalex.org/keywords/high-grade-osteosarcoma","display_name":"high-grade osteosarcoma","score":0.7889999747276306},{"id":"https://openalex.org/keywords/late-recurrence","display_name":"late recurrence","score":0.5009999871253967},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7379999756813049},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9630783796310425},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.8283641338348389},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6463276743888855},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5230323076248169},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47315582633018494},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.46498745679855347},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.44625434279441833},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.42178648710250854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40540942549705505},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06842532753944397},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2003.06.177","doi":"https://doi.org/10.1200/jco.2003.06.177","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2003.06.177","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:12525528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12525528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W56284330","https://openalex.org/W296831189","https://openalex.org/W1583261171","https://openalex.org/W1743757598","https://openalex.org/W1854116296","https://openalex.org/W1867002980","https://openalex.org/W1893223195","https://openalex.org/W1902222293","https://openalex.org/W1946181835","https://openalex.org/W1954845453","https://openalex.org/W1969334311","https://openalex.org/W1971861662","https://openalex.org/W1974907966","https://openalex.org/W1991169033","https://openalex.org/W1998666925","https://openalex.org/W2001630588","https://openalex.org/W2003536753","https://openalex.org/W2015639618","https://openalex.org/W2016507270","https://openalex.org/W2037385810","https://openalex.org/W2052512461","https://openalex.org/W2060688081","https://openalex.org/W2063759313","https://openalex.org/W2064501224","https://openalex.org/W2070842831","https://openalex.org/W2076612721","https://openalex.org/W2082903841","https://openalex.org/W2093754123","https://openalex.org/W2120788367","https://openalex.org/W2142136189","https://openalex.org/W2239924772","https://openalex.org/W2257936228","https://openalex.org/W2329218644","https://openalex.org/W2401243972","https://openalex.org/W2401488010","https://openalex.org/W2403636480","https://openalex.org/W2408300607","https://openalex.org/W2417907047","https://openalex.org/W2472702138","https://openalex.org/W4245103890","https://openalex.org/W4293241248","https://openalex.org/W4297631159","https://openalex.org/W4302043507"],"related_works":["https://openalex.org/W1985860620","https://openalex.org/W2999195277","https://openalex.org/W2065165564","https://openalex.org/W4306641919","https://openalex.org/W1969773980","https://openalex.org/W1974442111","https://openalex.org/W2124999916","https://openalex.org/W2116034353","https://openalex.org/W3200504766","https://openalex.org/W2886858875"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,104],"prognosis":[2],"for":[3,18,205],"patients":[4,19,53,171,189,206,233,266],"who":[5,190,234],"develop":[6],"metachronous":[7,33,75,117,192,237,269],"skeletal":[8,34,76,270],"osteosarcoma":[9],"(OS)":[10],"has":[11],"been":[12],"considered":[13],"grave":[14],"compared":[15],"with":[16,20,54,97,174,241,267],"that":[17,254],"relapse":[21],"limited":[22],"to":[23,113,124,137,151,158,166,181,217,224,265],"the":[24,28,40,108,114],"lungs.":[25],"We":[26],"investigated":[27],"incidence":[29],"and":[30,71,83,141,153,219,243],"outcome":[31],"of":[32,39,51,86,90,110,116,177,232,259],"OS":[35,58,112,118,193,261],"after":[36],"initial":[37,199],"treatment":[38,258],"primary":[41,57,111,260],"tumor.":[42],"PATIENTS":[43],"AND":[44],"METHODS:":[45],"Twenty-three":[46],"(median":[47],"age":[48],"18.7":[49],"years)":[50],"426":[52],"nonmetastatic,":[55],"high-grade":[56],"treated":[59],"at":[60],"Memorial":[61],"Sloan-Kettering":[62],"Cancer":[63],"Center":[64],"(New":[65],"York,":[66],"NY)":[67],"between":[68],"February":[69],"1973":[70],"May":[72],"2000":[73],"developed":[74,191,235],"OS.":[77,271],"Initial":[78],"therapy":[79,240],"included":[80],"combination":[81],"chemotherapy":[82,91,245],"surgery.":[84],"Treatment":[85],"subsequent":[87],"relapses":[88],"consisted":[89],"or":[92,95,98,196],"radiation":[93],"alone":[94],"surgery":[96,242],"without":[99],"additional":[100],"individualized":[101],"chemotherapy.":[102],"RESULTS:":[103],"median":[105],"time":[106],"from":[107,198],"diagnosis":[109],"development":[115],"was":[119,129,146,212],"1.4":[120],"years":[121,131],"(range,":[122,164,179],"0.2":[123],"11.3":[125],"years).":[126,139,186],"Median":[127],"survival":[128,145,203],"1.5":[130],"(95%":[132,148,155,214,221],"confidence":[133],"interval":[134],"[CI],":[135],"0.8":[136],"6.9":[138],"Two-":[140],"5-year":[142,201],"postmetachronous":[143,202,250],"overall":[144],"43.5%":[147],"CI,":[149,156,215,222],"23.2%":[150],"63.7%)":[152],"33%":[154],"13%":[157],"53%),":[159],"respectively.":[160,226],"At":[161],"last":[162],"follow-up":[163],"0.1":[165],"12.8":[167,182],"years),":[168],"five":[169],"(30.4%)":[170],"were":[172],"alive":[173],"no":[175],"evidence":[176],"disease":[178],"1.7":[180],"years;":[183],"median,":[184],"4.4":[185],"For":[187],"11":[188],"24":[194],"months":[195],"more":[197],"diagnosis,":[200],"rate":[204],"receiving":[207],"combined":[208],"modality":[209],"versus":[210],"monotherapy":[211],"83%":[213],"54%":[216],"100%)":[218],"40%":[220],"0%":[223],"83%),":[225],"CONCLUSION:":[227],"In":[228],"a":[229],"small":[230],"subset":[231],"late":[236,268],"OS,":[238],"combined-modality":[239],"aggressive":[244],"may":[246,262],"result":[247],"in":[248,257],"long-term":[249],"survival.":[251],"This":[252],"implies":[253],"principles":[255],"used":[256],"be":[263],"applied":[264]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
