{"id":"https://openalex.org/W2051287378","doi":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","title":"Anaesthesia for Caesarean section and neonatal acid\u2010base status: a meta\u2010analysis*","display_name":"Anaesthesia for Caesarean section and neonatal acid\u2010base status: a meta\u2010analysis*","publication_year":2005,"publication_date":"2005-06-16","ids":{"openalex":"https://openalex.org/W2051287378","doi":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","mag":"2051287378","pmid":"https://pubmed.ncbi.nlm.nih.gov/15960713"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2044.2005.04223.x","doi":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.2005.04223.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.2005.04223.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110166519","display_name":"F. Reynolds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"F. Reynolds","raw_affiliation_strings":["Department of Anaesthesia, St Thomas' Hospital, London SE1 7EH, UK. felicity.reynolds@btinternet.com","Emeritus Professor of Obstetric Anaesthesia, Department of Anaesthesia, St Thomas' Hospital, London SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesia, St Thomas' Hospital, London SE1 7EH, UK. felicity.reynolds@btinternet.com","institution_ids":["https://openalex.org/I1324925910"]},{"raw_affiliation_string":"Emeritus Professor of Obstetric Anaesthesia, Department of Anaesthesia, St Thomas' Hospital, London SE1 7EH, UK","institution_ids":["https://openalex.org/I1324925910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032448943","display_name":"Paul Townsend Seed","orcid":"https://orcid.org/0000-0001-7904-7933","observed_orcids":["https://orcid.org/0000-0001-7904-7933"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. T. Seed","raw_affiliation_strings":["Lecturer in Medical Statistics, Division of Reproductive Health, Endocrinology and Development, King's College, London SE1 7EH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lecturer in Medical Statistics, Division of Reproductive Health, Endocrinology and Development, King's College, London SE1 7EH, UK","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110166519"],"corresponding_institution_ids":["https://openalex.org/I1324925910"],"apc_list":{"value":4970,"currency":"USD","value_usd":4970},"apc_paid":null,"fwci":2.0007,"has_fulltext":true,"cited_by_count":268,"citation_normalized_percentile":{"value":0.8630137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"60","issue":"7","first_page":"636","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cesarean-section","display_name":"cesarean section","score":0.8880000114440918},{"id":"https://openalex.org/keywords/spinal-anesthesia","display_name":"spinal anesthesia","score":0.9670000076293945},{"id":"https://openalex.org/keywords/epidural-anesthesia","display_name":"epidural anesthesia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/umbilical-cord-blood-ph","display_name":"umbilical cord pH","score":0.8349999785423279},{"id":"https://openalex.org/keywords/base-deficit","display_name":"base deficit","score":0.6729999780654907},{"id":"https://openalex.org/keywords/neonatal-acid-base-status","display_name":"neonatal acid-base status","score":0.9800000190734863},{"id":"https://openalex.org/keywords/fetal-well-being","display_name":"fetal well-being","score":0.6790000200271606},{"id":"https://openalex.org/keywords/obstetric-anesthesia","display_name":"obstetric anesthesia","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9249598979949951},{"id":"https://openalex.org/C2776279924","wikidata":"https://www.wikidata.org/wiki/Q228036","display_name":"Caesarean section","level":3,"score":0.7917817831039429},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7035685777664185},{"id":"https://openalex.org/C2776983577","wikidata":"https://www.wikidata.org/wiki/Q166543","display_name":"General anaesthesia","level":2,"score":0.6638864278793335},{"id":"https://openalex.org/C2778964498","wikidata":"https://www.wikidata.org/wiki/Q1724233","display_name":"Umbilical artery","level":4,"score":0.638292670249939},{"id":"https://openalex.org/C2778984665","wikidata":"https://www.wikidata.org/wiki/Q219626","display_name":"Ephedrine","level":2,"score":0.5552505850791931},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4762035608291626},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.42004913091659546},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.32804936170578003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12344774603843689},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000767","descriptor_name":"Anesthesia, Epidural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000773","descriptor_name":"Anesthesia, Obstetrical","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000773","descriptor_name":"Anesthesia, Obstetrical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000775","descriptor_name":"Anesthesia, Spinal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002585","descriptor_name":"Cesarean Section","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2044.2005.04223.x","doi":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.2005.04223.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},{"id":"pmid:15960713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15960713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/d60a90a3-54bd-4f51-bd14-15794e7af2af","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/d60a90a3-54bd-4f51-bd14-15794e7af2af","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reynolds, F & Seed, P T 2005, 'Anaesthesia for Caesarean section and neonatal acid-base status: a meta-analysis', Anaesthesia, vol. 60, no. 7, pp. 636 - 653. https://doi.org/10.1111/j.1365-2044.2005.04223.x","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2044.2005.04223.x","doi":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2044.2005.04223.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.2005.04223.x","source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320325703","display_name":"Tommy's","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051287378.pdf","grobid_xml":"https://content.openalex.org/works/W2051287378.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W55122224","https://openalex.org/W56705273","https://openalex.org/W101868886","https://openalex.org/W188077819","https://openalex.org/W257292813","https://openalex.org/W1482099777","https://openalex.org/W1491405722","https://openalex.org/W1546729296","https://openalex.org/W1550963345","https://openalex.org/W1593640066","https://openalex.org/W1843251998","https://openalex.org/W1968135559","https://openalex.org/W1971507169","https://openalex.org/W1980790079","https://openalex.org/W1986374229","https://openalex.org/W1986739121","https://openalex.org/W1987105999","https://openalex.org/W1988674312","https://openalex.org/W1990337803","https://openalex.org/W1991700975","https://openalex.org/W1993853061","https://openalex.org/W1995414912","https://openalex.org/W1996323358","https://openalex.org/W1998964965","https://openalex.org/W2003620200","https://openalex.org/W2004405792","https://openalex.org/W2006019663","https://openalex.org/W2006223221","https://openalex.org/W2007316116","https://openalex.org/W2007810500","https://openalex.org/W2007947698","https://openalex.org/W2012568676","https://openalex.org/W2014199186","https://openalex.org/W2014315332","https://openalex.org/W2016194419","https://openalex.org/W2016850501","https://openalex.org/W2017863090","https://openalex.org/W2017903333","https://openalex.org/W2019538365","https://openalex.org/W2019922586","https://openalex.org/W2022181125","https://openalex.org/W2024855444","https://openalex.org/W2027347965","https://openalex.org/W2028254528","https://openalex.org/W2032984056","https://openalex.org/W2039200481","https://openalex.org/W2045716525","https://openalex.org/W2059253797","https://openalex.org/W2063646742","https://openalex.org/W2068826022","https://openalex.org/W2072434722","https://openalex.org/W2079406000","https://openalex.org/W2080748679","https://openalex.org/W2087446250","https://openalex.org/W2089654382","https://openalex.org/W2091183633","https://openalex.org/W2091401062","https://openalex.org/W2107328434","https://openalex.org/W2108860922","https://openalex.org/W2112863517","https://openalex.org/W2112883553","https://openalex.org/W2114508735","https://openalex.org/W2115844174","https://openalex.org/W2122291517","https://openalex.org/W2123601567","https://openalex.org/W2131689332","https://openalex.org/W2132133228","https://openalex.org/W2135225257","https://openalex.org/W2135329844","https://openalex.org/W2137726436","https://openalex.org/W2143531164","https://openalex.org/W2148195475","https://openalex.org/W2150194501","https://openalex.org/W2154697526","https://openalex.org/W2157823046","https://openalex.org/W2158772649","https://openalex.org/W2164108929","https://openalex.org/W2214549743","https://openalex.org/W2320243937","https://openalex.org/W2335514002","https://openalex.org/W2395157875","https://openalex.org/W2409301844","https://openalex.org/W2414699822","https://openalex.org/W2417435517","https://openalex.org/W2523722742","https://openalex.org/W3187573583","https://openalex.org/W4233715288","https://openalex.org/W4241790818","https://openalex.org/W4253401800"],"related_works":["https://openalex.org/W2333935314","https://openalex.org/W2113487739","https://openalex.org/W1537641332","https://openalex.org/W2137726436","https://openalex.org/W2514634109","https://openalex.org/W1519967159","https://openalex.org/W2073126850","https://openalex.org/W55122224","https://openalex.org/W2414699822","https://openalex.org/W1593640066"],"abstract_inverted_index":{"Spinal":[0,139],"anaesthesia":[1,37,77,128,140,149],"is":[2,13],"generally":[3],"preferred":[4],"for":[5,10,111,114,150],"Caesarean":[6],"section.":[7],"Its":[8],"superiority":[9],"the":[11,95,151],"baby":[12],"often":[14],"assumed.":[15],"Umbilical":[16],"artery":[17,43],"acid-base":[18,31],"status":[19],"provides":[20],"a":[21,104],"valid":[22],"index":[23],"of":[24,36,91],"fetal":[25],"welfare.":[26],"Twenty-seven":[27],"studies":[28,102],"reporting":[29],"neonatal":[30],"data":[32],"with":[33,58,61],"different":[34],"types":[35],"were":[38],"used":[39],"to":[40,69,83,94],"compare":[41],"umbilical":[42],"or":[44,147],"vein":[45],"pH":[46,54],"and":[47,75,126],"base":[48,105],"deficit,":[49,106],"using":[50],"random-effect":[51],"meta-analysis.":[52],"Cord":[53],"was":[55,108],"significantly":[56,109],"lower":[57],"spinal":[59,112],"than":[60,113,145],"both":[62],"general":[63,115,148],"(difference:":[64],"-0.015;":[65],"95%":[66,80,118,131],"CI":[67,81,119,132],"-0.029":[68],"-0.001;":[70],"13":[71],"studies,":[72,86,123,136],"1272":[73],"subjects)":[74],"epidural":[76,127,146],"(difference":[78,116,129],"-0.013;":[79],"-0.024":[82],"-0.002;":[84],"11":[85],"828":[87],"subjects).":[88,138],"Larger":[89],"doses":[90],"ephedrine":[92],"contributed":[93],"latter":[96],"effect":[97],"(p":[98],"=":[99],"0.023).":[100],"Sixteen":[101],"reported":[103],"which":[107],"higher":[110],"1.109;":[117],"0.434-1.784":[120],"mEq.l(-1);":[121,134],"seven":[122,135],"695":[124],"subject)":[125],"0.910;":[130],"0.222-1.598":[133],"497":[137],"cannot":[141],"be":[142],"considered":[143],"safer":[144],"fetus.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}