{"id":"https://openalex.org/W2051276994","doi":"https://doi.org/10.1002/cne.902850109","title":"Glucocorticoid receptor\u2010immunoreactivity in C1, C2, and C3 adrenergic neurons that project to the hypothalamus or to the spinal cord in the rat","display_name":"Glucocorticoid receptor\u2010immunoreactivity in C1, C2, and C3 adrenergic neurons that project to the hypothalamus or to the spinal cord in the rat","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W2051276994","doi":"https://doi.org/10.1002/cne.902850109","mag":"2051276994","pmid":"https://pubmed.ncbi.nlm.nih.gov/2754045"},"language":"en","primary_location":{"id":"doi:10.1002/cne.902850109","doi":"https://doi.org/10.1002/cne.902850109","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.902850109","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028880120","display_name":"Paul E. Sawchenko","orcid":"https://orcid.org/0000-0002-8258-1296","observed_orcids":["https://orcid.org/0000-0002-8258-1296"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. E. Sawchenko","raw_affiliation_strings":["Salk Institute for Biological Studies, San Diego, CA 92138","The Salk Institute for Biological Studies and The Clayton Foundation for Research California Division, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies, San Diego, CA 92138","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Salk Institute for Biological Studies and The Clayton Foundation for Research California Division, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110478071","display_name":"Martha Churchill Bohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. C. Bohn","raw_affiliation_strings":["Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York 14642","institution_ids":["https://openalex.org/I28792581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028880120"],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.8084,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.84605598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"285","issue":"1","first_page":"107","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5313000082969666,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.12280000001192093,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.09860000014305115,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adrenergic-neurons","display_name":"adrenergic neurons","score":0.8799999952316284},{"id":"https://openalex.org/keywords/phenylethanolamine-n-methyltransferase","display_name":"phenylethanolamine N-methyltransferase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/paraventricular-nucleus","display_name":"paraventricular nucleus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/spinal-cord-projections","display_name":"spinal cord projections","score":0.8190000057220459},{"id":"https://openalex.org/keywords/medulla-oblongata","display_name":"medulla oblongata","score":0.7419999837875366},{"id":"https://openalex.org/keywords/retrograde-tracing","display_name":"retrograde tracing","score":0.7590000033378601},{"id":"https://openalex.org/keywords/adrenal-function","display_name":"adrenal function","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7865941524505615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.647392749786377},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.6128483414649963},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.600452184677124},{"id":"https://openalex.org/C2776512019","wikidata":"https://www.wikidata.org/wiki/Q1816418","display_name":"Efferent","level":3,"score":0.5833836793899536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5784565210342407},{"id":"https://openalex.org/C2776804559","wikidata":"https://www.wikidata.org/wiki/Q7181429","display_name":"Phenylethanolamine","level":4,"score":0.5719555020332336},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5674696564674377},{"id":"https://openalex.org/C2910300410","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Adrenergic Neurons","level":4,"score":0.48929306864738464},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.48290228843688965},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.4673823416233063},{"id":"https://openalex.org/C2779546955","wikidata":"https://www.wikidata.org/wiki/Q411541","display_name":"Phenylethanolamine N-methyltransferase","level":5,"score":0.4654698371887207},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.4398342967033386},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37206172943115234},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3192936182022095},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.18136826157569885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12442126870155334},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.06541791558265686},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.06440755724906921}],"mesh":[{"descriptor_ui":"D000320","descriptor_name":"Adrenergic Fibers","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004525","descriptor_name":"Efferent Pathways","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cne.902850109","doi":"https://doi.org/10.1002/cne.902850109","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cne.902850109","pdf_url":null,"source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"pmid:2754045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2754045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4378485455","display_name":"PATHWAYS INTEGRATING STRESS AND CARDIOVASCULAR RESPONSES","funder_award_id":"R01HL035137","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5354592557","display_name":null,"funder_award_id":"NS21182","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5636308187","display_name":"GLUCOCORTICOIDS AND BRAIN DEVELOPMENT","funder_award_id":"R01NS020832","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W221359381","https://openalex.org/W1493116705","https://openalex.org/W1573635199","https://openalex.org/W1966076107","https://openalex.org/W1966464425","https://openalex.org/W1968568694","https://openalex.org/W1972377663","https://openalex.org/W1979945171","https://openalex.org/W1984190029","https://openalex.org/W1984594416","https://openalex.org/W1987797235","https://openalex.org/W1993269927","https://openalex.org/W2002082814","https://openalex.org/W2005590134","https://openalex.org/W2007804882","https://openalex.org/W2009064702","https://openalex.org/W2015613847","https://openalex.org/W2022045360","https://openalex.org/W2023605292","https://openalex.org/W2024599586","https://openalex.org/W2032751475","https://openalex.org/W2034251427","https://openalex.org/W2043225482","https://openalex.org/W2046575894","https://openalex.org/W2051659058","https://openalex.org/W2054134853","https://openalex.org/W2061939501","https://openalex.org/W2062360803","https://openalex.org/W2063912965","https://openalex.org/W2067210690","https://openalex.org/W2071823161","https://openalex.org/W2081106406","https://openalex.org/W2084576709","https://openalex.org/W2089750332","https://openalex.org/W2091061724","https://openalex.org/W2122743097","https://openalex.org/W2138926432","https://openalex.org/W2145864819","https://openalex.org/W2158649743","https://openalex.org/W2166453886","https://openalex.org/W2203725745","https://openalex.org/W2272928600","https://openalex.org/W2416001710"],"related_works":["https://openalex.org/W1981453234","https://openalex.org/W2155615145","https://openalex.org/W2071823161","https://openalex.org/W1979945171","https://openalex.org/W1972377663","https://openalex.org/W2015613847","https://openalex.org/W1970986760","https://openalex.org/W1987797235","https://openalex.org/W2063912965","https://openalex.org/W2034315981"],"abstract_inverted_index":{"A":[0],"combined":[1],"retrograde":[2],"transport-double":[3],"immunohistochemical":[4],"staining":[5],"method":[6],"was":[7],"used":[8],"to":[9,13,28,56,152,163],"determine":[10],"the":[11,29,33,37,46,57,61,66,84,89,92,104,111,127,153,157,161,165,183],"extent":[12],"which":[14],"rat":[15],"liver":[16],"glucocorticoid":[17],"receptor-immunoreactivity":[18],"(GR-ir)":[19],"is":[20,168],"contained":[21],"within":[22],"phenylethanolamine-N-methyltransferase":[23],"(PNMT)-ir":[24],"neurons":[25,72,96,190,202],"that":[26,43,65,97,116,160],"project":[27],"paraventricular":[30],"nucleus":[31],"of":[32,60,69,88,94,110,176,194,213],"hypothalamus":[34],"(PVH)":[35],"or":[36,197],"spinal":[38,90,122,154],"cord.":[39],"The":[40,141],"results":[41,142],"confirmed":[42],"cells":[44,115],"in":[45,73,83,103,126,182,188,207],"C1,":[47],"C2,":[48],"and":[49,63,129,159,210,218],"C3":[50,130],"adrenergic":[51,58,95,147,189,201],"cell":[52,106,148],"groups":[53,149],"each":[54,74],"contribute":[55,150],"innervation":[59],"PVH,":[62,158],"indicated":[64],"great":[67],"majority":[68],"retrogradely":[70,99,119],"labeled":[71,100,120],"group":[75],"(80%":[76],"overall)":[77],"also":[78],"express":[79,164],"GR-ir.":[80,140],"Following":[81],"injections":[82,123],"upper":[85],"thoracic":[86],"segments":[87],"cord,":[91],"bulk":[93],"were":[98,101,124,186],"found":[102],"C1":[105],"group,":[107],"though":[108,171],"31%":[109],"total":[112],"number":[113],"PNMT-ir":[114,136,177],"could":[117],"be":[118],"following":[121],"localized":[125],"C2":[128],"regions.":[131],"Of":[132],"these":[133],"spinally":[134],"projecting":[135],"neurons,":[137],"62%":[138],"displayed":[139],"suggest":[143],"all":[144],"three":[145],"medullary":[146],"projections":[151],"cord":[155],"and/or":[156],"capacity":[162],"GR":[166],"phenotype":[167],"a":[169,192,205],"common,":[170],"perhaps":[172],"not":[173],"universal,":[174],"attribute":[175],"neurons.":[178],"No":[179],"pronounced":[180],"differences":[181],"expression":[184],"GR-ir":[185],"observed":[187],"as":[191],"function":[193,215],"their":[195],"location":[196],"efferent":[198],"projections.":[199,220],"Brainstem":[200],"may":[203],"play":[204],"role":[206],"integrating":[208],"neuronal":[209],"hormonal":[211],"controls":[212],"adrenal":[214],"via":[216],"ascending":[217],"descending":[219]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
