{"id":"https://openalex.org/W2051244366","doi":"https://doi.org/10.5414/cpp47303","title":"Ciprofloxacin-associated seizures in a patient with underlying thyrotoxicosis: case report and literature review","display_name":"Ciprofloxacin-associated seizures in a patient with underlying thyrotoxicosis: case report and literature review","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2051244366","doi":"https://doi.org/10.5414/cpp47303","mag":"2051244366","pmid":"https://pubmed.ncbi.nlm.nih.gov/19473592"},"language":"en","primary_location":{"id":"doi:10.5414/cpp47303","doi":"https://doi.org/10.5414/cpp47303","is_oa":false,"landing_page_url":"https://doi.org/10.5414/cpp47303","pdf_url":null,"source":{"id":"https://openalex.org/S166536441","display_name":"International Journal of Clinical Pharmacology and Therapeutics","issn_l":"0946-1965","issn":["0946-1965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310313675","host_organization_name":"Dustri-Verlag","host_organization_lineage":["https://openalex.org/P4310313675"],"host_organization_lineage_names":["Dustri-Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int. Journal of Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017196938","display_name":"Kemal A\u011fbaht","orcid":"https://orcid.org/0000-0003-3122-5491","observed_orcids":["https://orcid.org/0000-0003-3122-5491"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"K. Agbaht","raw_affiliation_strings":["Department of Internal Medicine, Endocrinology and Metabolism Unit, Ankara University Faculty of Medicine, Sihhiye, Ankara, Turkey. dr_kemal@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Endocrinology and Metabolism Unit, Ankara University Faculty of Medicine, Sihhiye, Ankara, Turkey. dr_kemal@yahoo.com","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054401299","display_name":"Berivan B\u0131t\u0131k","orcid":"https://orcid.org/0000-0001-5803-915X","observed_orcids":["https://orcid.org/0000-0001-5803-915X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Bitik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013405328","display_name":"Serhan Pi\u015fkinpa\u015fa","orcid":"https://orcid.org/0000-0002-5494-8468","observed_orcids":["https://orcid.org/0000-0002-5494-8468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Piskinpasa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034207640","display_name":"Mehmet Bayraktar","orcid":"https://orcid.org/0000-0003-2306-6531","observed_orcids":["https://orcid.org/0000-0003-2306-6531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Bayraktar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082103240","display_name":"Arzu Topeli","orcid":"https://orcid.org/0000-0002-5874-9087","observed_orcids":["https://orcid.org/0000-0002-5874-9087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Topeli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4456,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80122212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"47","issue":"05","first_page":"303","last_page":"310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.1876000016927719,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.12939999997615814,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/drug-induced-seizures","display_name":"drug-induced seizures","score":0.9309999942779541},{"id":"https://openalex.org/keywords/thyrotoxicosis","display_name":"thyrotoxicosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/postpartum-thyroiditis","display_name":"postpartum thyroiditis","score":0.996999979019165},{"id":"https://openalex.org/keywords/fluoroquinolone-adverse-effects","display_name":"fluoroquinolone adverse effects","score":0.8080000281333923},{"id":"https://openalex.org/keywords/seizure-risk-factors","display_name":"seizure risk factors","score":0.777999997138977},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.6019999980926514},{"id":"https://openalex.org/keywords/myopathy","display_name":"myopathy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/differential-diagnosis-of-seizures","display_name":"differential diagnosis of seizures","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8668395280838013},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5618694424629211},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5150746703147888},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.49994921684265137},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4181517958641052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35161322355270386},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3451046347618103},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.27702581882476807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013971","descriptor_name":"Thyrotoxicosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014552","descriptor_name":"Urinary Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5414/cpp47303","doi":"https://doi.org/10.5414/cpp47303","is_oa":false,"landing_page_url":"https://doi.org/10.5414/cpp47303","pdf_url":null,"source":{"id":"https://openalex.org/S166536441","display_name":"International Journal of Clinical Pharmacology and Therapeutics","issn_l":"0946-1965","issn":["0946-1965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310313675","host_organization_name":"Dustri-Verlag","host_organization_lineage":["https://openalex.org/P4310313675"],"host_organization_lineage_names":["Dustri-Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int. Journal of Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:19473592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19473592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology and therapeutics","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2462098548","https://openalex.org/W2060222634","https://openalex.org/W2162289672","https://openalex.org/W2403613076","https://openalex.org/W1987444599","https://openalex.org/W2144473444","https://openalex.org/W2055513682","https://openalex.org/W2160793202","https://openalex.org/W2208278595","https://openalex.org/W2266670711"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ciprofloxacin-associated":[1],"seizures":[2],"(CAS)":[3],"occur":[4],"most":[5],"commonly":[6],"in":[7,133,148,188,200,205],"patients":[8,206],"with":[9,135,167,207],"special":[10],"risk":[11,52,155,169,193],"factors":[12],"that":[13,31],"may":[14,32],"cause":[15],"accumulation":[16],"of":[17,21,36,42,60,73,145,151,186],"drug":[18,28],"(high":[19],"doses":[20],"the":[22,34,58,70,140,149,184,201],"drug,":[23],"old":[24],"age,":[25],"renal":[26,79],"insufficiency,":[27],"interactions)":[29],"or":[30],"decrease":[33],"threshold":[35],"epileptogenic":[37],"activity":[38],"(electrolyte":[39],"abnormalities,":[40],"history":[41],"seizures,":[43],"electroconvulsive":[44],"therapy).":[45],"OBJECTIVE:":[46],"To":[47],"report":[48],"thyrotoxicosis":[49,132,195],"as":[50],"a":[51,181],"factor":[53,156],"previously":[54,191],"not":[55,100],"heralded":[56],"for":[57,84,157,217],"development":[59],"CAS.":[61,158],"CASE":[62],"SUMMARY:":[63],"A":[64],"24-year-old":[65],"woman":[66],"was":[67,99,126],"admitted":[68],"to":[69,91,162,165,176,190],"hospital":[71],"because":[72],"convulsions,":[74],"severe":[75],"myopathy,":[76],"and":[77,86,105,112],"acute":[78],"failure":[80],"after":[81],"taking":[82],"ciprofloxacin":[83,92,213],"sinusitis,":[85],"urinary":[87],"tract":[88],"infections.":[89],"Prior":[90],"ingestion,":[93],"she":[94],"had":[95],"no":[96],"seizure":[97],"history,":[98],"receiving":[101],"any":[102],"other":[103,211],"medication,":[104],"her":[106],"routine":[107],"laboratory":[108,129],"results":[109],"including":[110],"creatinine":[111],"electrolytes":[113],"were":[114],"within":[115],"normal":[116],"ranges.":[117],"Electroencephalogram":[118],"suggested":[119],"epileptiform":[120],"waves.":[121],"Cranial":[122],"magnetic":[123],"resonance":[124],"imaging":[125],"normal.":[127],"Further":[128],"examinations":[130],"documented":[131],"association":[134],"postpartum":[136],"thyroiditis.":[137],"DISCUSSION:":[138],"In":[139],"reviewed":[141],"literature,":[142],"all":[143],"cases":[144],"CAS":[146,160],"occurred":[147],"presence":[150],"at":[152],"least":[153],"one":[154],"CONCLUSIONS:":[159],"appear":[161],"be":[163,198,215],"restricted":[164],"individuals":[166],"predisposing":[168],"factors,":[170,194],"therefore":[171],"it":[172],"is":[173],"always":[174],"necessary":[175],"search":[177],"such":[178],"fact.":[179],"When":[180],"physician":[182],"encounters":[183],"possibility":[185],"CAS,":[187],"addition":[189],"described":[192],"should":[196],"also":[197],"considered":[199],"differential":[202],"diagnosis.":[203],"Further,":[204],"untreated":[208],"thyrotoxicosis,":[209],"antibiotics":[210],"than":[212],"might":[214],"preferable":[216],"therapy.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}