{"id":"https://openalex.org/W2051237347","doi":"https://doi.org/10.1111/j.1432-1033.1978.tb12135.x","title":"Histone Phosphorylation and Chromatin Structure during Mitosis in Chinese Hamster Cells","display_name":"Histone Phosphorylation and Chromatin Structure during Mitosis in Chinese Hamster Cells","publication_year":1978,"publication_date":"1978-03-01","ids":{"openalex":"https://openalex.org/W2051237347","doi":"https://doi.org/10.1111/j.1432-1033.1978.tb12135.x","mag":"2051237347","pmid":"https://pubmed.ncbi.nlm.nih.gov/206429"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1978.tb12135.x","doi":"https://doi.org/10.1111/j.1432-1033.1978.tb12135.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1978.tb12135.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110034381","display_name":"Lawrence R. Gurley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence R. GURLEY","raw_affiliation_strings":["Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091484920","display_name":"Joseph A. D'Anna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. D'ANNA","raw_affiliation_strings":["Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108628518","display_name":"S.S. Barham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven S. BARHAM","raw_affiliation_strings":["Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060046174","display_name":"Larry L. Deaven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry L. DEAVEN","raw_affiliation_strings":["Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108408373","display_name":"Robert A. Tobey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. TOBEY","raw_affiliation_strings":["Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Group, Los Alamos Scientific Laboratory, University of California, Los Alamos, New Mexico, U.S.A. 87545","institution_ids":["https://openalex.org/I1343871089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343871089"],"apc_list":null,"apc_paid":null,"fwci":8.1345,"has_fulltext":false,"cited_by_count":538,"citation_normalized_percentile":{"value":0.98829409,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"84","issue":"1","first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-phosphorylation","display_name":"histone phosphorylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/histone-h1","display_name":"histone H1","score":0.847000002861023},{"id":"https://openalex.org/keywords/histone-h3","display_name":"histone H3","score":1.0},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chromosome-condensation","display_name":"chromosome condensation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chromatin-aggregation","display_name":"chromatin aggregation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/mitotic-exit","display_name":"mitotic exit","score":0.47099998593330383},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.675000011920929},{"id":"https://openalex.org/keywords/colcemid","display_name":"colcemid","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C45413362","wikidata":"https://www.wikidata.org/wiki/Q6013254","display_name":"Prophase","level":4,"score":0.8255763053894043},{"id":"https://openalex.org/C53420372","wikidata":"https://www.wikidata.org/wiki/Q22299157","display_name":"Anaphase","level":4,"score":0.7795644998550415},{"id":"https://openalex.org/C178108356","wikidata":"https://www.wikidata.org/wiki/Q7240230","display_name":"Premature chromosome condensation","level":4,"score":0.7551913857460022},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.6957187056541443},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6866791248321533},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6825398206710815},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6613823175430298},{"id":"https://openalex.org/C141561535","wikidata":"https://www.wikidata.org/wiki/Q12565265","display_name":"Telophase","level":5,"score":0.651517927646637},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.6132227182388306},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.5268375277519226},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.5252435207366943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5247307419776917},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.475620299577713},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.46949151158332825},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.369579017162323},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3471667766571045},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.19570571184158325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1950232982635498},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1390010118484497},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.11602821946144104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006656","descriptor_name":"Protamine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1432-1033.1978.tb12135.x","doi":"https://doi.org/10.1111/j.1432-1033.1978.tb12135.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1978.tb12135.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:206429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/206429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W252178604","https://openalex.org/W594356966","https://openalex.org/W1482723536","https://openalex.org/W1517953140","https://openalex.org/W1522695514","https://openalex.org/W1540521703","https://openalex.org/W1547908140","https://openalex.org/W1549004484","https://openalex.org/W1555044868","https://openalex.org/W1559378392","https://openalex.org/W1570759257","https://openalex.org/W1574385690","https://openalex.org/W1963493061","https://openalex.org/W1965219854","https://openalex.org/W1966503216","https://openalex.org/W1984339582","https://openalex.org/W1985527733","https://openalex.org/W1995527354","https://openalex.org/W1996266432","https://openalex.org/W1996555564","https://openalex.org/W2002223314","https://openalex.org/W2006431144","https://openalex.org/W2013447794","https://openalex.org/W2017077715","https://openalex.org/W2018626566","https://openalex.org/W2019710182","https://openalex.org/W2028895755","https://openalex.org/W2028938083","https://openalex.org/W2033299243","https://openalex.org/W2033917594","https://openalex.org/W2040044705","https://openalex.org/W2047482758","https://openalex.org/W2047767613","https://openalex.org/W2057850047","https://openalex.org/W2059722081","https://openalex.org/W2069469862","https://openalex.org/W2090947724","https://openalex.org/W2109401564","https://openalex.org/W2115659567","https://openalex.org/W2124754523","https://openalex.org/W2131400267","https://openalex.org/W2143224884","https://openalex.org/W2176858216","https://openalex.org/W2196306349","https://openalex.org/W2316838174","https://openalex.org/W2322149866","https://openalex.org/W4205523048","https://openalex.org/W4230281702","https://openalex.org/W4235591502"],"related_works":["https://openalex.org/W2059722081","https://openalex.org/W1482723536","https://openalex.org/W2187131565","https://openalex.org/W2019494208","https://openalex.org/W2010649437","https://openalex.org/W2048109276","https://openalex.org/W2024559058","https://openalex.org/W199231646","https://openalex.org/W4281793508","https://openalex.org/W1555044868"],"abstract_inverted_index":{"Histone":[0],"phosphorylation":[1,103,109,136,151,175,277],"and":[2,121,130,191,213,235,263,275,305,320,335,340],"chromatin":[3,44,49,82,124,160,169,180,327],"structure":[4,328],"were":[5,196,218],"examined":[6],"in":[7,20,37,92,119,159,294],"synchronized":[8],"CHO":[9],"Chinese":[10],"hamster":[11],"cells":[12,222,260],"during":[13,51,64,84,122,138,163,172,333,346],"progression":[14],"through":[15],"mitosis.":[16,347],"Cell":[17],"population":[18],"distribution":[19],"various":[21],"phases":[22],"of":[23,43,47,58,89,127,141,168,187,221,230,239,250,292,296,310],"mitosis":[24,32,68,128,188],"was":[25,33,69,176],"determined":[26],"by":[27,54,87],"electron":[28],"microscopy.":[29],"Entry":[30],"into":[31,45,61,80],"seen":[34],"to":[35,232,242,254],"occur":[36,283],"two":[38],"stages:":[39],"(1)":[40],"the":[41,56,73,123,142,156,184,228,237,300,311,337],"gathering":[42],"aggregates":[46,60,91],"dense":[48,81],"clumps":[50,83],"preprophase,":[52],"followed":[53,86],"(2)":[55],"condensation":[57,332],"these":[59,90,98,139,259,297],"chromosome":[62,194,331],"structures":[63,195],"prophase.":[65],"Exit":[66,220],"from":[67,223],"observed":[70,162],"essentially":[71],"as":[72,204,258],"reverse":[74],"process,":[75],"chromosomes":[76,286],"first":[77],"being":[78],"disorganized":[79],"telophase,":[85],"dispersion":[88],"early":[93],"G":[94,265],"1":[95,266],".":[96,267],"Correlating":[97],"structural":[99,181],"changes":[100,158],"with":[101,155,178,227,236],"histone":[102,107,134,174,201,215],"revealed":[104],"that":[105,148,271,302,317,336],"interphase\u2010type":[106],"H1":[108,149,202,240,244,252,256,272,303,319,338],"(H1":[110,207],"I":[111,150,253],")":[112,209],"involving":[113],"1\u20133":[114],"phosphates":[115],"per":[116],"molecule":[117],"existed":[118,203],"interphase":[120,164,334],"aggregation":[125],"stages":[126],"(preprophase":[129],"telophase).":[131],"Also,":[132],"no":[133],"H3":[135,216,231,234,276,306,321,341],"occurred":[137,257],"periods":[140],"cell":[143],"cycle.":[144],"It":[145,314],"is":[146,315],"proposed":[147,316],"may":[152,322],"be":[153],"involved":[154],"submicroscopic":[157],"organization":[161],"using":[165],"molecular":[166],"probes":[167],"structure.":[170],"However,":[171],"mitosis,":[173],"correlated":[177,225],"microscopic":[179],"changes.":[182],"During":[183],"second":[185],"stage":[186],"(prophase,":[189],"metaphase,":[190],"anaphase),":[192],"when":[193,285],"fully":[197,288],"condensed,":[198],"virtually":[199],"all":[200,214],"superphosphorylated":[205],"molecules":[206,217],"M":[208,241,273,304,339],"containing":[210,245],"3\u20136":[211],"phosphates,":[212],"phosphorylated.":[219],"anaphase":[224],"closely":[226],"dephosphorylation":[229,238,249],"unphosphorylated":[233,255],"subphosphorylated":[243,251],"0\u20133":[246],"phosphates.":[247],"Further":[248],"left":[261],"telophase":[262],"entered":[264],"These":[268],"experiments":[269,298],"demonstrated":[270],"superphosphorylation":[274],"are":[278,287,308],"strictly":[279],"mitotic":[280],"events":[281],"which":[282,329],"only":[284],"condensed.":[289],"The":[290],"absence":[291],"Colcemid":[293,312],"some":[295],"eliminates":[299],"possibility":[301],"phosphorylations":[307,342],"artifacts":[309],"treatment.":[313],"histones":[318],"impose":[323],"a":[324],"restriction":[325,345],"on":[326],"prevents":[330],"remove":[343],"this":[344]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}