{"id":"https://openalex.org/W2051154783","doi":"https://doi.org/10.1039/b815368j","title":"Antimicrobial activity, biocompatibility and hydrogelation ability of dipeptide-based amphiphiles","display_name":"Antimicrobial activity, biocompatibility and hydrogelation ability of dipeptide-based amphiphiles","publication_year":2008,"publication_date":"2008-11-05","ids":{"openalex":"https://openalex.org/W2051154783","doi":"https://doi.org/10.1039/b815368j","mag":"2051154783","pmid":"https://pubmed.ncbi.nlm.nih.gov/19081951"},"language":"en","primary_location":{"id":"doi:10.1039/b815368j","doi":"https://doi.org/10.1039/b815368j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b815368j","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086899741","display_name":"Rajendra Narayan Mitra","orcid":"https://orcid.org/0000-0003-0654-9654","observed_orcids":["https://orcid.org/0000-0003-0654-9654"]},"institutions":[{"id":"https://openalex.org/I165998391","display_name":"Indian Association for the Cultivation of Science","ror":"https://ror.org/050p6gz73","country_code":"IN","type":"education","lineage":["https://openalex.org/I165998391"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajendra Narayan Mitra","raw_affiliation_strings":["Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700 032, India","\u2002Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700 032, India","institution_ids":["https://openalex.org/I165998391"]},{"raw_affiliation_string":"\u2002Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India","institution_ids":["https://openalex.org/I165998391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084635780","display_name":"Anshupriya Shome","orcid":"https://orcid.org/0000-0002-7977-7351","observed_orcids":["https://orcid.org/0000-0002-7977-7351"]},"institutions":[{"id":"https://openalex.org/I165998391","display_name":"Indian Association for the Cultivation of Science","ror":"https://ror.org/050p6gz73","country_code":"IN","type":"education","lineage":["https://openalex.org/I165998391"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anshupriya Shome","raw_affiliation_strings":["Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India","institution_ids":["https://openalex.org/I165998391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029983746","display_name":"Pritha Paul","orcid":"https://orcid.org/0009-0007-8167-1103","observed_orcids":["https://orcid.org/0009-0007-8167-1103"]},"institutions":[{"id":"https://openalex.org/I165998391","display_name":"Indian Association for the Cultivation of Science","ror":"https://ror.org/050p6gz73","country_code":"IN","type":"education","lineage":["https://openalex.org/I165998391"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pritha Paul","raw_affiliation_strings":["Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India","institution_ids":["https://openalex.org/I165998391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070603351","display_name":"Prasanta Kumar Das","orcid":"https://orcid.org/0000-0002-0203-8446","observed_orcids":["https://orcid.org/0000-0002-0203-8446"]},"institutions":[{"id":"https://openalex.org/I165998391","display_name":"Indian Association for the Cultivation of Science","ror":"https://ror.org/050p6gz73","country_code":"IN","type":"education","lineage":["https://openalex.org/I165998391"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Prasanta Kumar Das","raw_affiliation_strings":["Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India","institution_ids":["https://openalex.org/I165998391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070603351"],"corresponding_institution_ids":["https://openalex.org/I165998391"],"apc_list":null,"apc_paid":null,"fwci":2.9705,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.88998638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"94","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.1574999988079071,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cationic-peptides","display_name":"cationic peptides","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.746999979019165},{"id":"https://openalex.org/keywords/hydrogelation","display_name":"hydrogelation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.6940000057220459},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.953000009059906},{"id":"https://openalex.org/keywords/supramolecular-networks","display_name":"supramolecular networks","score":0.6729999780654907},{"id":"https://openalex.org/keywords/noncovalent-self-assembly","display_name":"noncovalent self-assembly","score":0.7490000128746033},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5519999861717224},{"id":"https://openalex.org/keywords/l-amino-acids","display_name":"L-amino acids","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.8713237047195435},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8360334634780884},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.8263165950775146},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.801810622215271},{"id":"https://openalex.org/C2779138802","wikidata":"https://www.wikidata.org/wiki/Q418602","display_name":"Dipeptide","level":3,"score":0.7730407118797302},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7589381337165833},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5376677513122559},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.526546061038971},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.4620683789253235},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.4347954988479614},{"id":"https://openalex.org/C2778457984","wikidata":"https://www.wikidata.org/wiki/Q415798","display_name":"Nisin","level":3,"score":0.42592117190361023},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.41633981466293335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35872286558151245},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32878297567367554},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.28780731558799744},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25216782093048096},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.09376782178878784},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0934516191482544},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.07239019870758057},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.058916836977005005}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/b815368j","doi":"https://doi.org/10.1039/b815368j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b815368j","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},{"id":"pmid:19081951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19081951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W82875452","https://openalex.org/W590207526","https://openalex.org/W1586905176","https://openalex.org/W1963606380","https://openalex.org/W1964897041","https://openalex.org/W1968563250","https://openalex.org/W1974457420","https://openalex.org/W1974795477","https://openalex.org/W1979901694","https://openalex.org/W1980320854","https://openalex.org/W1982664201","https://openalex.org/W1984607450","https://openalex.org/W1991645509","https://openalex.org/W1993125234","https://openalex.org/W1993906884","https://openalex.org/W1998575884","https://openalex.org/W2005656463","https://openalex.org/W2009684692","https://openalex.org/W2010666335","https://openalex.org/W2017617810","https://openalex.org/W2017955739","https://openalex.org/W2017968349","https://openalex.org/W2019333542","https://openalex.org/W2021494226","https://openalex.org/W2025810401","https://openalex.org/W2032036006","https://openalex.org/W2036860085","https://openalex.org/W2043178887","https://openalex.org/W2051158595","https://openalex.org/W2054526986","https://openalex.org/W2054602599","https://openalex.org/W2058803399","https://openalex.org/W2061749384","https://openalex.org/W2066959435","https://openalex.org/W2067924010","https://openalex.org/W2071313815","https://openalex.org/W2077930487","https://openalex.org/W2079266092","https://openalex.org/W2079468421","https://openalex.org/W2079665383","https://openalex.org/W2092004590","https://openalex.org/W2099912595","https://openalex.org/W2107254607","https://openalex.org/W2118995881","https://openalex.org/W2121878743","https://openalex.org/W2131121307","https://openalex.org/W2141025633","https://openalex.org/W2150226037","https://openalex.org/W2164611493","https://openalex.org/W2166871728","https://openalex.org/W2177065716","https://openalex.org/W2575699064"],"related_works":["https://openalex.org/W4382940771","https://openalex.org/W2760256730","https://openalex.org/W2135964866","https://openalex.org/W1986133287","https://openalex.org/W2768030574","https://openalex.org/W2025810401","https://openalex.org/W4415070490","https://openalex.org/W2807011744","https://openalex.org/W7213315966","https://openalex.org/W2907945052"],"abstract_inverted_index":{"The":[0,82,113,152],"development":[1,133],"of":[2,6,15,51,86,97,120,134,154],"new":[3],"antibiotics":[4],"is":[5],"increasing":[7],"importance":[8],"due":[9],"to":[10],"the":[11,33,93,98,117,132,143],"growing":[12],"resistance":[13],"power":[14],"microbes":[16],"against":[17],"conventional":[18],"drugs.":[19],"To":[20],"this":[21],"end,":[22],"cationic":[23,41,88,123],"peptides":[24],"are":[25],"emerging":[26],"as":[27,75,77,127],"clinically":[28],"potent":[29],"antimicrobial":[30,84,135],"agents.":[31],"In":[32,141],"present":[34],"study,":[35],"we":[36],"have":[37],"synthesized":[38],"six":[39],"dipeptide-based":[40],"amphiphiles":[42,56,102,124,144],"with":[43,137],"different":[44],"head":[45,94],"group":[46,95],"structures":[47],"by":[48,92,162],"varying":[49],"combinations":[50],"l-amino":[52],"acid":[53],"residues.":[54],"These":[55],"showed":[57,145],"remarkable":[58],"growth":[59],"inhibiting":[60],"activity":[61],"on":[62,78],"several":[63],"Gram-positive":[64],"(minimum":[65],"inhibitory":[66],"concentration":[67],"(MIC)=0.1-10":[68],"microg/mL)":[69,73],"and":[70,164],"Gram-negative":[71],"(MIC=5-150":[72],"bacteria":[74],"well":[76],"fungus":[79],"(MIC=1-50":[80],"microg/mL).":[81],"inherent":[83],"efficacies":[85],"these":[87,101],"dipeptides":[89],"were":[90],"influenced":[91],"architecture":[96],"amphiphiles.":[99],"Encouragingly,":[100],"selectively":[103],"attacked":[104],"microbial":[105],"cells,":[106],"while":[107],"showing":[108],"biocompatibility":[109],"toward":[110],"mammalian":[111],"cells.":[112],"results":[114],"show":[115],"that":[116],"rational":[118],"designing":[119],"short":[121],"peptide-based":[122],"might":[125],"serve":[126],"a":[128],"promising":[129],"strategy":[130],"in":[131,158],"agents":[136],"greater":[138],"cell":[139],"specificities.":[140],"addition,":[142],"water":[146],"gelation":[147,159],"ability":[148],"at":[149],"room":[150],"temperature.":[151],"formation":[153],"non-covalent":[155],"supramolecular":[156],"networks":[157],"was":[160],"established":[161],"microscopic":[163],"spectroscopic":[165],"studies.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}