{"id":"https://openalex.org/W2051152995","doi":"https://doi.org/10.1164/ajrccm/142.5.1143","title":"Bronchial Responsiveness to Histamine in Infants and Older Children","display_name":"Bronchial Responsiveness to Histamine in Infants and Older Children","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W2051152995","doi":"https://doi.org/10.1164/ajrccm/142.5.1143","mag":"2051152995","pmid":"https://pubmed.ncbi.nlm.nih.gov/2240836"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm/142.5.1143","doi":"https://doi.org/10.1164/ajrccm/142.5.1143","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/142.5.1143","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038285432","display_name":"Stephen Michael Stick","orcid":"https://orcid.org/0000-0002-5386-8482","observed_orcids":["https://orcid.org/0000-0002-5386-8482"]},"institutions":[{"id":"https://openalex.org/I2800419323","display_name":"Princess Margaret Hospital for Children","ror":"https://ror.org/04ec98z42","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800419323","https://openalex.org/I2800882159","https://openalex.org/I4387155440"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephen M. Stick","raw_affiliation_strings":["Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Western Australia","institution_ids":["https://openalex.org/I2800419323"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sally Turnbull","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sally Turnbull","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082233842","display_name":"Hock Leng Chua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hock Leng Chua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103698652","display_name":"Louis I. Landau","orcid":"https://orcid.org/0009-0009-9071-5627","observed_orcids":["https://orcid.org/0009-0009-9071-5627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis I. Landau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041041126","display_name":"Peter Neils Le Sou\u00ebf","orcid":"https://orcid.org/0000-0003-0930-1654","observed_orcids":["https://orcid.org/0000-0003-0930-1654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter N. Lesou\u00ebf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6895,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90886574,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"142","issue":"5","first_page":"1143","last_page":"1146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-responsiveness","display_name":"airway responsiveness","score":0.9649999737739563},{"id":"https://openalex.org/keywords/histamine-challenge","display_name":"histamine challenge","score":0.8370000123977661},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.9470000267028809},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.847000002861023},{"id":"https://openalex.org/keywords/air-entrainment","display_name":"air entrainment","score":0.6919999718666077},{"id":"https://openalex.org/keywords/aerosol-dilution","display_name":"aerosol dilution","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7009889483451843},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6587987542152405},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.5206702947616577},{"id":"https://openalex.org/C40222840","wikidata":"https://www.wikidata.org/wiki/Q185049","display_name":"Geometric mean","level":2,"score":0.46137866377830505},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.44530338048934937},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.43862199783325195},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.38065463304519653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3779069781303406},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3448858857154846},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2959606647491455},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17704185843467712},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.06799313426017761}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005540","descriptor_name":"Forced Expiratory Flow Rates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005652","descriptor_name":"Functional Residual Capacity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014028","descriptor_name":"Tobacco Smoke Pollution","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm/142.5.1143","doi":"https://doi.org/10.1164/ajrccm/142.5.1143","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/142.5.1143","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},{"id":"pmid:2240836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2240836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W287198160","https://openalex.org/W1791043497","https://openalex.org/W1940857632","https://openalex.org/W1989892307","https://openalex.org/W2035777861","https://openalex.org/W2075270092","https://openalex.org/W2171362682","https://openalex.org/W2179330369","https://openalex.org/W2263774430","https://openalex.org/W2409892119","https://openalex.org/W2412234027"],"related_works":["https://openalex.org/W2056521007","https://openalex.org/W7100309907","https://openalex.org/W4239730656","https://openalex.org/W2100306897","https://openalex.org/W2001105148","https://openalex.org/W1506259320","https://openalex.org/W2110164614","https://openalex.org/W2005189249","https://openalex.org/W2014596603","https://openalex.org/W2022439487"],"abstract_inverted_index":{"Normal":[0],"infants":[1,37,147,191,220],"have":[2],"been":[3],"shown":[4],"to":[5,7,26,32,45,60,77,86,178],"respond":[6],"a":[8,48,64,123],"relatively":[9],"low":[10],"concentration":[11,118],"of":[12,50,66,119,145,156,174,184,200,207],"inhaled":[13],"histamine.":[14],"However,":[15,166],"those":[16],"studies":[17],"used":[18],"partial":[19],"maximal":[20],"expiratory":[21,101],"flow":[22,102,129],"volume":[23,103],"(PMEFV)":[24],"curves":[25,82,95,110],"assess":[27,87],"lung":[28,88],"function.":[29,89],"In":[30,90],"order":[31],"directly":[33],"compare":[34],"responsiveness":[35,44,209,214],"between":[36,47,190],"and":[38,63,192,210,221],"older":[39,69,107,158,193,222],"children,":[40,70,108],"we":[41],"compared":[42],"bronchial":[43,213],"histamine":[46,120,208],"group":[49,65],"45":[51],"normal":[52,219],"infants,":[53],"median":[54,71],"age":[55,72],"4":[56],"wk":[57],"(range":[58,75],"2":[59],"6":[61],"wk)":[62],"30":[67],"nonasthmatic":[68],"10":[73],"yr":[74],"5":[76],"15":[78],"yr)":[79],"using":[80,98],"PMEFV":[81,94,109,139],"in":[83,127,204,218],"both":[84],"groups":[85],"the":[91,99,106,138,146,153,157,175,198,205],"infant":[92],"group,":[93],"were":[96,111,169,186],"generated":[97,112],"forced":[100],"technique.":[104],"For":[105],"by":[113],"voluntary":[114],"effort.":[115],"The":[116,141],"provocative":[117],"that":[121,212],"produced":[122],"40%":[124],"fall":[125],"(PC40)":[126],"maximum":[128],"at":[130],"functional":[131],"residual":[132],"capacity":[133],"(VmaxFRC)":[134],"was":[135,150],"calculated":[136],"from":[137],"curves.":[140],"geometric":[142,154],"mean":[143,155],"PC40":[144,185],"(1.02":[148],"g/L)":[149,161],"lower":[151],"than":[152,164],"children":[159],"(3.4":[160],"(p":[162],"less":[163],"0.001).":[165],"these":[167],"results":[168,196],"then":[170],"corrected":[171],"for":[172,202],"dilution":[173],"aerosol":[176],"due":[177],"air":[179],"entrainment":[180],"(AE).":[181],"Corrected":[182],"values":[183],"not":[187],"significantly":[188],"different":[189],"children.":[194,223],"These":[195],"demonstrate":[197],"importance":[199],"accounting":[201],"AE":[203],"evaluation":[206],"suggest":[211],"may":[215],"be":[216],"similar":[217]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
