{"id":"https://openalex.org/W2051140751","doi":"https://doi.org/10.1021/bi00382a027","title":"Acceleration of surface-dependent autocatalytic activation of blood coagulation factor XII by divalent metal ions","display_name":"Acceleration of surface-dependent autocatalytic activation of blood coagulation factor XII by divalent metal ions","publication_year":1987,"publication_date":"1987-04-01","ids":{"openalex":"https://openalex.org/W2051140751","doi":"https://doi.org/10.1021/bi00382a027","mag":"2051140751","pmid":"https://pubmed.ncbi.nlm.nih.gov/3113477"},"language":"en","primary_location":{"id":"doi:10.1021/bi00382a027","doi":"https://doi.org/10.1021/bi00382a027","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00382a027","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110875015","display_name":"Joseph D. Shore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph D. Shore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026423363","display_name":"Duane E. Day","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duane E. Day","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046718241","display_name":"PAUL E. BOCK","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul E. Bock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055990354","display_name":"Steven T. Olson","orcid":"https://orcid.org/0000-0002-6083-7510","observed_orcids":["https://orcid.org/0000-0002-6083-7510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven T. Olson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1738,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.77546218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"26","issue":"8","first_page":"2250","last_page":"2258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autocatalytic-activation","display_name":"autocatalytic activation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dextran-sulfate","display_name":"dextran sulfate","score":0.7979999780654907},{"id":"https://openalex.org/keywords/divalent-metal-ions","display_name":"divalent metal ions","score":0.9049999713897705},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.6449999809265137},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.9829999804496765},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.9860000014305115},{"id":"https://openalex.org/keywords/reaction-kinetics","display_name":"reaction kinetics","score":0.8069999814033508},{"id":"https://openalex.org/keywords/ionic-strength-dependence","display_name":"ionic strength dependence","score":0.7519999742507935},{"id":"https://openalex.org/keywords/apparent-km","display_name":"apparent Km","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.5973743796348572},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.5789768695831299},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46095800399780273},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.4417842626571655},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.4190284013748169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37177610397338867},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3613196611404419},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.304521381855011},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002413","descriptor_name":"Cations, Divalent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00382a027","doi":"https://doi.org/10.1021/bi00382a027","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00382a027","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:3113477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3113477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1852977695","display_name":null,"funder_award_id":"HL-25670-05","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G774448033","display_name":null,"funder_award_id":"HL32373","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1525916153","https://openalex.org/W1557125148","https://openalex.org/W1595893033","https://openalex.org/W1739927186","https://openalex.org/W1892344960","https://openalex.org/W1967058565","https://openalex.org/W1967508759","https://openalex.org/W1969495396","https://openalex.org/W1970772713","https://openalex.org/W1988306684","https://openalex.org/W1996282461","https://openalex.org/W2002341869","https://openalex.org/W2002497059","https://openalex.org/W2003285078","https://openalex.org/W2005060011","https://openalex.org/W2010540517","https://openalex.org/W2014277394","https://openalex.org/W2015038774","https://openalex.org/W2023985064","https://openalex.org/W2041911603","https://openalex.org/W2059975829","https://openalex.org/W2064932000","https://openalex.org/W2066149593","https://openalex.org/W2067614175","https://openalex.org/W2069612260","https://openalex.org/W2092462079","https://openalex.org/W2109939055","https://openalex.org/W2114053013","https://openalex.org/W2157488373","https://openalex.org/W2328805967","https://openalex.org/W2402037950","https://openalex.org/W2415223370","https://openalex.org/W2419065318","https://openalex.org/W2465957509","https://openalex.org/W2467467260","https://openalex.org/W2734898845"],"related_works":["https://openalex.org/W1984735470","https://openalex.org/W1522465380","https://openalex.org/W2016215660","https://openalex.org/W2025663739","https://openalex.org/W1513749471","https://openalex.org/W1988306684","https://openalex.org/W2114053013","https://openalex.org/W1973031099","https://openalex.org/W1514319676","https://openalex.org/W1945689620"],"abstract_inverted_index":{"The":[0,125],"effect":[1,69],"of":[2,9,15,39,67,70,83,87,95,106,120,129,145,165,183,186,217],"divalent":[3],"metal":[4],"ions":[5],"on":[6,72,80,223],"the":[7,37,68,81,93,98,118,143,163,173,179,184,196,199,218],"rate":[8,38,119,175],"dextran":[10,45,84,130],"sulfate":[11,46,131],"dependent":[12],"autocatalytic":[13,108],"activation":[14,42,75],"human":[16],"blood":[17],"coagulation":[18],"factor":[19,40,73,122,133,139,151],"XII":[20,41,74,123,134,140,152],"was":[21],"studied":[22],"at":[23,50,188],"pH":[24],"7.4":[25],"and":[26,31,53,102,192,220],"25":[27],"degrees":[28],"C.":[29],"Zn2+":[30,71,115,146,171,205],"Cu2+,":[32],"but":[33,153],"not":[34],"Co2+,":[35],"increased":[36,136,172,206],"induced":[43,132],"by":[44,89,177,204],"with":[47,114,138],"optimum":[48],"effects":[49],"approximately":[51],"5":[52,166],"1":[54],"microM,":[55],"respectively,":[56,211],"while":[57],"Ca2+":[58],"acceleration":[59],"required":[60],"much":[61],"higher":[62],"concentrations":[63],"(millimolar).":[64],"Further":[65],"investigation":[66],"demonstrated":[76],"a":[77,214],"complete":[78],"dependence":[79,216],"presence":[82,164],"sulfate,":[85],"lack":[86],"inhibition":[88],"soybean":[90],"trypsin":[91],"inhibitor,":[92],"appearance":[94],"alpha-XIIa":[96],"as":[97],"primary":[99],"reaction":[100,103,174],"product,":[101],"kinetics":[104,185],"characteristic":[105],"an":[107],"process.":[109],"These":[110],"results":[111],"were":[112],"consistent":[113],"affecting":[116],"only":[117],"surface-mediated":[121],"autoactivation.":[124],"initial":[126],"turnover":[127],"velocity":[128],"autoactivation":[135,187],"linearly":[137],"concentration":[141,160],"in":[142,162,198],"absence":[144],"up":[147],"to":[148,209,213],"0.9":[149],"microM":[150,167],"showed":[154],"saturation":[155],"behavior":[156],"over":[157],"this":[158],"same":[159],"range":[161],"Zn2+,":[168],"indicating":[169],"that":[170,195],"primarily":[176],"lowering":[178],"apparent":[180,200],"Km.":[181],"Comparison":[182],"mu":[189],"=":[190],"0.15":[191],"0.24":[193],"revealed":[194],"enhancement":[197],"kcat/Km":[201],"brought":[202],"about":[203],"from":[207],"19-fold":[208],"520-fold,":[210],"due":[212],"differential":[215],"Zn2+-stimulated":[219],"unstimulated":[221],"reactions":[222],"ionic":[224],"strength.(ABSTRACT":[225],"TRUNCATED":[226],"AT":[227],"250":[228],"WORDS)":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
