{"id":"https://openalex.org/W2051099484","doi":"https://doi.org/10.1038/sj.icb.7100048","title":"Anti\u2010BDCA\u20104 (neuropilin\u20101) antibody can suppress virus\u2010induced IFN\u2010alpha production of plasmacytoid dendritic cells","display_name":"Anti\u2010BDCA\u20104 (neuropilin\u20101) antibody can suppress virus\u2010induced IFN\u2010alpha production of plasmacytoid dendritic cells","publication_year":2007,"publication_date":"2007-04-03","ids":{"openalex":"https://openalex.org/W2051099484","doi":"https://doi.org/10.1038/sj.icb.7100048","mag":"2051099484","pmid":"https://pubmed.ncbi.nlm.nih.gov/17404592"},"language":"en","primary_location":{"id":"doi:10.1038/sj.icb.7100048","doi":"https://doi.org/10.1038/sj.icb.7100048","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.icb.7100048","pdf_url":null,"source":{"id":"https://openalex.org/S41617351","display_name":"Immunology and Cell Biology","issn_l":"0004-945X","issn":["0004-945X","0818-9641","1440-1711"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology &amp; Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047956095","display_name":"Evelin Grage\u2010Griebenow","orcid":"https://orcid.org/0009-0006-7159-3079","observed_orcids":["https://orcid.org/0009-0006-7159-3079"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Evelin Grage\u2010Griebenow","raw_affiliation_strings":["Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079053829","display_name":"Stefan L\u00f6seke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan L\u00f6seke","raw_affiliation_strings":["Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033078367","display_name":"Marion Kauth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marion Kauth","raw_affiliation_strings":["Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019958105","display_name":"Kirsten Gehlhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kirsten Gehlhar","raw_affiliation_strings":["Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090317439","display_name":"Rainer Zawatzky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Zawatzky","raw_affiliation_strings":["Department FO30, German Cancer Research Centre Heidelberg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department FO30, German Cancer Research Centre Heidelberg Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088875589","display_name":"Albrecht Bufe","orcid":"https://orcid.org/0000-0001-7335-9362","observed_orcids":["https://orcid.org/0000-0001-7335-9362"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Albrecht Bufe","raw_affiliation_strings":["Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088875589"],"corresponding_institution_ids":["https://openalex.org/I904495901"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.0778,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.75758669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"85","issue":"5","first_page":"383","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.08590000122785568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"neuropilin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cpg-oligodeoxynucleotides","display_name":"CpG oligodeoxynucleotides","score":0.9160000085830688},{"id":"https://openalex.org/keywords/magnetic-activated-cell-sorting","display_name":"magnetic cell separation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/lineage-negative-cells","display_name":"lineage-negative cells","score":0.48500001430511475},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6177693605422974},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5514243841171265},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4952141344547272},{"id":"https://openalex.org/C2776051438","wikidata":"https://www.wikidata.org/wiki/Q12045567","display_name":"Plasmacytoid dendritic cell","level":4,"score":0.451262503862381},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4336537718772888},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3845405876636505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38451236486434937},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3743246793746948},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3438979983329773},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29631507396698},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.2634977698326111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2003401815891266},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15648207068443298},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D052736","descriptor_name":"Rous sarcoma virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D052736","descriptor_name":"Rous sarcoma virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053585","descriptor_name":"Virus Attachment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.icb.7100048","doi":"https://doi.org/10.1038/sj.icb.7100048","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.icb.7100048","pdf_url":null,"source":{"id":"https://openalex.org/S41617351","display_name":"Immunology and Cell Biology","issn_l":"0004-945X","issn":["0004-945X","0818-9641","1440-1711"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology &amp; Cell Biology","raw_type":"journal-article"},{"id":"pmid:17404592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17404592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology and cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1645985361","display_name":"Klinische Forschergruppe Bochum: Bedeutung von Virusinfektionen bei akuten und chronischen Atemwegsinfektionen im Kindes- und Erwachsenenalter (2. F\u00f6rderphase)","funder_award_id":"01GC0101","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2829665143","display_name":null,"funder_award_id":"FKZ 01GC 9802/8","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1517310071","https://openalex.org/W1538844879","https://openalex.org/W1550301398","https://openalex.org/W1972165294","https://openalex.org/W1975054545","https://openalex.org/W1979238901","https://openalex.org/W1985473643","https://openalex.org/W1986513431","https://openalex.org/W1990983421","https://openalex.org/W2045425092","https://openalex.org/W2048143404","https://openalex.org/W2056209198","https://openalex.org/W2059377172","https://openalex.org/W2062350041","https://openalex.org/W2067817921","https://openalex.org/W2073542937","https://openalex.org/W2100578643","https://openalex.org/W2109916571","https://openalex.org/W2113779347","https://openalex.org/W2122643628","https://openalex.org/W2137599689","https://openalex.org/W2140734388","https://openalex.org/W4297626711"],"related_works":["https://openalex.org/W1972165294","https://openalex.org/W1556732909","https://openalex.org/W2106566281","https://openalex.org/W2134512036","https://openalex.org/W2005538857","https://openalex.org/W2018344097","https://openalex.org/W2050233114","https://openalex.org/W2157363713","https://openalex.org/W1277950236","https://openalex.org/W2136696747"],"abstract_inverted_index":{"Plasmacytoid":[0],"dendritic":[1],"cells":[2,48],"(PDC)":[3],"in":[4,94],"human":[5],"blood":[6,45,79],"are":[7],"the":[8,28,108],"main":[9],"source":[10],"of":[11,42,77,85],"virus-induced":[12,101],"interferon":[13],"(IFN)-alpha.":[14],"They":[15],"exhibit":[16],"a":[17],"lineage-negative":[18],"phenotype":[19],"but":[20,119],"all":[21],"express":[22],"BDCA-4,":[23],"which":[24,70],"is":[25,37,52,105],"homologous":[26],"to":[27,67,145],"neuronal":[29],"receptor":[30],"neuropilin-1.":[31],"Specific":[32],"staining":[33],"with":[34,89],"anti-BDCA-4":[35,90],"antibody":[36,109],"used":[38],"for":[39,136,142],"positive":[40],"isolation":[41],"PDC":[43,58,88,139],"from":[44],"by":[46,74,125],"magnetic":[47,75],"sorting.":[49],"Here,":[50],"it":[51],"demonstrated":[53,141],"that":[54,107],"these":[55,86],"positively":[56],"selected":[57,73],"showed":[59],"reduced":[60,100],"or":[61,99,115],"completely":[62],"abolished":[63],"IFN-alpha":[64,102,122,143],"release":[65,123],"compared":[66],"unstained":[68,87],"PDC,":[69],"were":[71],"negatively":[72],"depletion":[76],"lineage-positive":[78],"mononuclear":[80],"cells.":[81],"In":[82,129],"addition,":[83],"treatment":[84],"mAb":[91],"also":[92,120],"resulted":[93],"at":[95],"least":[96],"two-fold":[97],"lower":[98],"production.":[103],"It":[104],"shown":[106],"not":[110],"only":[111],"affects":[112],"cell":[113],"survival":[114],"block":[116],"virus":[117],"attachment":[118],"reduces":[121],"induced":[124],"non-viral":[126],"CpG":[127],"oligodeoxynucleotides.":[128],"conclusion,":[130],"data":[131],"suggest":[132],"an":[133],"immunoregulatory":[134],"role":[135],"BDCA-4":[137],"on":[138],"as":[140],"response":[144],"virus.":[146]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
