{"id":"https://openalex.org/W2051090749","doi":"https://doi.org/10.1016/0969-2126(93)90019-d","title":"Determination of the NMR solution structure of the Hoechst 33258-d(GTGGAATTCCAC)2 complex and comparison with the X-ray crystal structure","display_name":"Determination of the NMR solution structure of the Hoechst 33258-d(GTGGAATTCCAC)2 complex and comparison with the X-ray crystal structure","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2051090749","doi":"https://doi.org/10.1016/0969-2126(93)90019-d","mag":"2051090749","pmid":"https://pubmed.ncbi.nlm.nih.gov/16100952"},"language":"en","primary_location":{"id":"doi:10.1016/0969-2126(93)90019-d","doi":"https://doi.org/10.1016/0969-2126(93)90019-d","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0969-2126(93)90019-d","pdf_url":null,"source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000236783","display_name":"Agostino Fede","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Agostino Fede","raw_affiliation_strings":["Institut f\u00fcr Molekularbiologie und Biophysik, ETH-H\u00f6nggerberg, CH-8093 Z\u00fcrich, Switzerland","Pharma Division, Preclinical Research and New Technologies, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biophysik, ETH-H\u00f6nggerberg, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]},{"raw_affiliation_string":"Pharma Division, Preclinical Research and New Technologies, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021829717","display_name":"Martin Billeter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin Billeter","raw_affiliation_strings":["Institut f\u00fcr Molekularbiologie und Biophysik ETH-H\u00f6nggerberg, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biophysik ETH-H\u00f6nggerberg, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081776053","display_name":"Werner Leupin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Werner Leupin","raw_affiliation_strings":["Pharma Division, Preclinical Research and New Technologies, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharma Division, Preclinical Research and New Technologies, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000254356","display_name":"Kurt W\u00fcthrich A","orcid":"https://orcid.org/0000-0001-8739-6965","observed_orcids":["https://orcid.org/0000-0001-8739-6965","https://orcid.org/0000-0003-2612-6616"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kurt W\u00fcthrich","raw_affiliation_strings":["Institut f\u00fcr Molekularbiologie und Biophysik ETH-H\u00f6nggerberg, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biophysik ETH-H\u00f6nggerberg, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":null,"fwci":1.6729,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.84636314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1","issue":"3","first_page":"177","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hoechst-33258","display_name":"Hoechst 33258","score":1.0},{"id":"https://openalex.org/keywords/dna-minor-groove-binding","display_name":"DNA minor groove binding","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dna-dye-complexes","display_name":"dye-DNA complexes","score":0.7210000157356262},{"id":"https://openalex.org/keywords/solution-structure","display_name":"solution structure","score":0.7549999952316284},{"id":"https://openalex.org/keywords/conformational-heterogeneity","display_name":"conformational heterogeneity","score":0.6610000133514404},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.6700000166893005},{"id":"https://openalex.org/keywords/crystal-structure-comparison","display_name":"crystal structure comparison","score":0.6370000243186951},{"id":"https://openalex.org/keywords/intermolecular-hydrogen-bonding","display_name":"intermolecular hydrogen bonding","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6562860012054443},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.6332224607467651},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6255536079406738},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.5896279811859131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.587130069732666},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.5456417798995972},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5204882025718689},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.483153760433197},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.46139049530029297},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.4525836706161499},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42145252227783203},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.4102481007575989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11362960934638977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10197418928146362},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006690","descriptor_name":"Bisbenzimidazole","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006690","descriptor_name":"Bisbenzimidazole","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009692","descriptor_name":"Nucleic Acid Heteroduplexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009692","descriptor_name":"Nucleic Acid Heteroduplexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0969-2126(93)90019-d","doi":"https://doi.org/10.1016/0969-2126(93)90019-d","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0969-2126(93)90019-d","pdf_url":null,"source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},{"id":"pmid:16100952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16100952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W34532530","https://openalex.org/W57286102","https://openalex.org/W1491642680","https://openalex.org/W1656714822","https://openalex.org/W1966902568","https://openalex.org/W1969776708","https://openalex.org/W1975222435","https://openalex.org/W1976106600","https://openalex.org/W1988092676","https://openalex.org/W1992207564","https://openalex.org/W1992981497","https://openalex.org/W1995999180","https://openalex.org/W1996991816","https://openalex.org/W1997011390","https://openalex.org/W2000669268","https://openalex.org/W2004469739","https://openalex.org/W2015790692","https://openalex.org/W2019005479","https://openalex.org/W2020382931","https://openalex.org/W2023314902","https://openalex.org/W2023572962","https://openalex.org/W2027058762","https://openalex.org/W2034541138","https://openalex.org/W2048668515","https://openalex.org/W2051653118","https://openalex.org/W2052078861","https://openalex.org/W2053933852","https://openalex.org/W2058716517","https://openalex.org/W2059975335","https://openalex.org/W2061823522","https://openalex.org/W2065207842","https://openalex.org/W2070669085","https://openalex.org/W2075854877","https://openalex.org/W2078120502","https://openalex.org/W2087019832","https://openalex.org/W2094487655","https://openalex.org/W2095068850","https://openalex.org/W2100921103","https://openalex.org/W2103036049","https://openalex.org/W2113905952","https://openalex.org/W2114604378","https://openalex.org/W2139044006","https://openalex.org/W2157200038","https://openalex.org/W2162166182","https://openalex.org/W2401018874","https://openalex.org/W2419466012","https://openalex.org/W2504864860","https://openalex.org/W2949250147","https://openalex.org/W2975209960","https://openalex.org/W4409143561"],"related_works":["https://openalex.org/W2058716517","https://openalex.org/W1992981497","https://openalex.org/W2070669085","https://openalex.org/W2087019832","https://openalex.org/W2016915490","https://openalex.org/W2033421162","https://openalex.org/W6928600241","https://openalex.org/W2075070782","https://openalex.org/W2053933852","https://openalex.org/W2075854877"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}