{"id":"https://openalex.org/W2051007663","doi":"https://doi.org/10.1021/jm500159d","title":"Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects","display_name":"Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects","publication_year":2014,"publication_date":"2014-06-30","ids":{"openalex":"https://openalex.org/W2051007663","doi":"https://doi.org/10.1021/jm500159d","mag":"2051007663","pmid":"https://pubmed.ncbi.nlm.nih.gov/24978316","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136663"},"language":"en","primary_location":{"id":"doi:10.1021/jm500159d","doi":"https://doi.org/10.1021/jm500159d","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm500159d","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm500159d","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/jm500159d","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111895480","display_name":"Morgan Le Naour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Le Naour","raw_affiliation_strings":["University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States","Therapeutics Discovery and Development Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]},{"raw_affiliation_string":"Therapeutics Discovery and Development Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054113458","display_name":"Mary M. Lunzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary M. Lunzer","raw_affiliation_strings":["University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","Department of Medicinal#R#Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114,#R#308 Harvard Street SE, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Medicinal#R#Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114,#R#308 Harvard Street SE, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael D. Powers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Powers","raw_affiliation_strings":["University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","Department of Medicinal#R#Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114,#R#308 Harvard Street SE, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Medicinal#R#Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114,#R#308 Harvard Street SE, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111660979","display_name":"Alexander E. Kalyuzhny","orcid":"https://orcid.org/0000-0003-2508-5955","observed_orcids":["https://orcid.org/0000-0003-2508-5955"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander E. Kalyuzhny","raw_affiliation_strings":["University of Minnesota , , , ,","Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044032618","display_name":"Michael A. Benneyworth","orcid":"https://orcid.org/0000-0001-9574-3939","observed_orcids":["https://orcid.org/0000-0001-9574-3939"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Benneyworth","raw_affiliation_strings":["University of Minnesota , , , ,","Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059910786","display_name":"Mark John Thomas","orcid":"https://orcid.org/0000-0001-5721-5350","observed_orcids":["https://orcid.org/0000-0001-5721-5350"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Thomas","raw_affiliation_strings":["University of Minnesota , , , ,","Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Neuroscience","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070230820","display_name":"Philip S. Portoghese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip S. Portoghese","raw_affiliation_strings":["University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota , , WDH 8-114, 308 Harvard Street SE , , ,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, WDH 8-114, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070230820"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.3219,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.78924442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"57","issue":"15","first_page":"6383","last_page":"6392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.3237000107765198,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/beta-arrestin-2","display_name":"\u03b2-arrestin2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/analgesics","display_name":"analgesics","score":0.6890000104904175},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.9100000262260437},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.46700000762939453},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.6840000152587891},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.41200000047683716},{"id":"https://openalex.org/keywords/side-effect-reduction","display_name":"side effect reduction","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8673340082168579},{"id":"https://openalex.org/C184389661","wikidata":"https://www.wikidata.org/wiki/Q14897645","display_name":"\u03ba-opioid receptor","level":4,"score":0.6287106275558472},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6194382309913635},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.582007884979248},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.564649224281311},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5202701687812805},{"id":"https://openalex.org/C43587935","wikidata":"https://www.wikidata.org/wiki/Q1258877","display_name":"Functional selectivity","level":4,"score":0.48867371678352356},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.4827077388763428},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4286733865737915},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4214288294315338},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3972938060760498},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23191121220588684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06635475158691406},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017465","descriptor_name":"Receptors, Opioid, delta","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/jm500159d","doi":"https://doi.org/10.1021/jm500159d","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm500159d","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm500159d","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3442425","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136663","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4136663","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136663","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Chem","raw_type":"Text"},{"id":"pmid:24978316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24978316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/jm500159d","doi":"https://doi.org/10.1021/jm500159d","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm500159d","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm500159d","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1683954143","display_name":"Ligands that target opioid-chemokine and opioid-mGlu5 heteromers","funder_award_id":"R01DA030316","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2120144651","display_name":null,"funder_award_id":"DA030316","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3436518628","display_name":"NINDS Center Core at the University of Minnesota","funder_award_id":"P30NS062158","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8446276915","display_name":null,"funder_award_id":"NS062158","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2051007663.pdf"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W193010663","https://openalex.org/W1519808555","https://openalex.org/W1548949496","https://openalex.org/W1556070936","https://openalex.org/W1586056486","https://openalex.org/W1655589213","https://openalex.org/W1852077611","https://openalex.org/W1852747819","https://openalex.org/W1929667086","https://openalex.org/W1953292148","https://openalex.org/W1964131185","https://openalex.org/W1971909322","https://openalex.org/W1976087970","https://openalex.org/W1979031324","https://openalex.org/W1984429646","https://openalex.org/W1996214244","https://openalex.org/W1998404855","https://openalex.org/W1999561809","https://openalex.org/W2002488130","https://openalex.org/W2004109806","https://openalex.org/W2006112766","https://openalex.org/W2006803138","https://openalex.org/W2008649251","https://openalex.org/W2010455608","https://openalex.org/W2013087295","https://openalex.org/W2013142447","https://openalex.org/W2014110722","https://openalex.org/W2015087988","https://openalex.org/W2016275972","https://openalex.org/W2016733882","https://openalex.org/W2020728213","https://openalex.org/W2023948580","https://openalex.org/W2027591014","https://openalex.org/W2030619634","https://openalex.org/W2031590523","https://openalex.org/W2034274806","https://openalex.org/W2038566061","https://openalex.org/W2040825227","https://openalex.org/W2044240689","https://openalex.org/W2050011778","https://openalex.org/W2053409539","https://openalex.org/W2054407280","https://openalex.org/W2054982830","https://openalex.org/W2059512977","https://openalex.org/W2059628641","https://openalex.org/W2063083641","https://openalex.org/W2064318896","https://openalex.org/W2066729230","https://openalex.org/W2067158308","https://openalex.org/W2071464244","https://openalex.org/W2073095955","https://openalex.org/W2073771628","https://openalex.org/W2074575290","https://openalex.org/W2077322233","https://openalex.org/W2079523532","https://openalex.org/W2080192851","https://openalex.org/W2080198258","https://openalex.org/W2086889423","https://openalex.org/W2091939203","https://openalex.org/W2094109627","https://openalex.org/W2095775529","https://openalex.org/W2095846787","https://openalex.org/W2096686163","https://openalex.org/W2107153432","https://openalex.org/W2109083102","https://openalex.org/W2110783096","https://openalex.org/W2111373319","https://openalex.org/W2117762969","https://openalex.org/W2122370526","https://openalex.org/W2124233079","https://openalex.org/W2128468891","https://openalex.org/W2129384252","https://openalex.org/W2130642464","https://openalex.org/W2135436766","https://openalex.org/W2135733191","https://openalex.org/W2136672278","https://openalex.org/W2137585418","https://openalex.org/W2139953381","https://openalex.org/W2143527646","https://openalex.org/W2145182954","https://openalex.org/W2146133935","https://openalex.org/W2152087829","https://openalex.org/W2158207659","https://openalex.org/W2158979382","https://openalex.org/W2163240506","https://openalex.org/W2165671231","https://openalex.org/W2166127927","https://openalex.org/W2167673522","https://openalex.org/W2169268349","https://openalex.org/W2206043426","https://openalex.org/W2211878186","https://openalex.org/W2264449916","https://openalex.org/W4296309414","https://openalex.org/W4297627420","https://openalex.org/W4406989418"],"related_works":["https://openalex.org/W7160873215","https://openalex.org/W2137585418","https://openalex.org/W2563699694","https://openalex.org/W2516443702","https://openalex.org/W1965981998","https://openalex.org/W1729052455","https://openalex.org/W2952626514","https://openalex.org/W2785485611","https://openalex.org/W2116167437","https://openalex.org/W2054244091"],"abstract_inverted_index":{"It":[0],"is":[1],"now":[2],"generally":[3],"recognized":[4],"that":[5,28,141],"upon":[6,66],"activation":[7,103],"by":[8],"an":[9,35,54],"agonist,":[10],"\u03b2-arrestin":[11,65],"associates":[12],"with":[13,42,96,101],"G":[14],"protein-coupled":[15],"receptors":[16],"and":[17,77,113],"acts":[18],"as":[19],"a":[20,24,46],"scaffold":[21],"in":[22,53,80,118,134],"creating":[23],"diverse":[25],"signaling":[26],"network":[27],"could":[29],"lead":[30],"to":[31,37,56,88,132,150],"adverse":[32,157],"effects.":[33,158],"As":[34,124],"approach":[36],"reducing":[38],"side":[39],"effects":[40],"associated":[41],"\u03ba":[43,60],"opioid":[44,61],"agonists,":[45],"series":[47],"of":[48,104,110,130,143,156],"\u03b2-naltrexamides":[49],"3-10":[50],"was":[51,99,108],"synthesized":[52],"effort":[55],"selectively":[57],"target":[58],"putative":[59,145],"heteromers":[62,79,146],"without":[63],"recruiting":[64],"activation.":[67],"The":[68],"most":[69],"potent":[70,90],"derivative":[71],"3":[72,87,107],"(INTA)":[73],"strongly":[74],"activated":[75],"KOR-DOR":[76,136],"KOR-MOR":[78],"HEK293":[81],"cells.":[82],"In":[83],"vivo":[84],"studies":[85,126],"revealed":[86],"produce":[89],"antinociception,":[91],"which,":[92],"when":[93],"taken":[94],"together":[95],"antagonism":[97],"data,":[98],"consistent":[100],"the":[102,119,148],"both":[105],"heteromers.":[106],"devoid":[109,155],"tolerance,":[111],"dependence,":[112],"showed":[114],"no":[115,128],"aversive":[116],"effect":[117],"conditioned":[120],"place":[121],"preference":[122],"assay.":[123],"immunofluorescence":[125],"indicated":[127],"recruitment":[129],"\u03b2-arrestin2":[131],"membranes":[133],"coexpressed":[135],"cells,":[137],"this":[138],"study":[139],"suggests":[140],"targeting":[142],"specific":[144],"has":[147],"potential":[149],"identify":[151],"leads":[152],"for":[153],"analgesics":[154]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}