{"id":"https://openalex.org/W2050992159","doi":"https://doi.org/10.1024/0301-1526/a000373","title":"New oral anticoagulants in the treatment of acute venous thromboembolism - a systematic review with indirect comparisons","display_name":"New oral anticoagulants in the treatment of acute venous thromboembolism - a systematic review with indirect comparisons","publication_year":2014,"publication_date":"2014-08-22","ids":{"openalex":"https://openalex.org/W2050992159","doi":"https://doi.org/10.1024/0301-1526/a000373","mag":"2050992159","pmid":"https://pubmed.ncbi.nlm.nih.gov/25147012"},"language":"en","primary_location":{"id":"doi:10.1024/0301-1526/a000373","doi":"https://doi.org/10.1024/0301-1526/a000373","is_oa":false,"landing_page_url":"https://doi.org/10.1024/0301-1526/a000373","pdf_url":null,"source":{"id":"https://openalex.org/S4210188602","display_name":"VASA","issn_l":"0301-1526","issn":["0301-1526","1664-2872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319871","host_organization_name":"Hogrefe Verlag","host_organization_lineage":["https://openalex.org/P4310319871"],"host_organization_lineage_names":["Hogrefe Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasa","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060584054","display_name":"Mirko Hirschl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101126","display_name":"Hanusch Hospital","ror":"https://ror.org/0163qhr63","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210101126"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Mirko Hirschl","raw_affiliation_strings":["Department of Angiology, Hanusch Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Angiology, Hanusch Hospital, Vienna, Austria","institution_ids":["https://openalex.org/I4210101126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005634785","display_name":"Michael Kundi","orcid":"https://orcid.org/0000-0002-2707-3213","observed_orcids":["https://orcid.org/0000-0002-2707-3213"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michael Kundi","raw_affiliation_strings":["Institute of Environmental Health, Medical University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Environmental Health, Medical University of Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.4355,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.97562417,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"5","first_page":"353","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acute-venous-thromboembolism","display_name":"acute venous thromboembolism","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vitamin-k-antagonists","display_name":"vitamin K antagonists","score":0.9710000157356262},{"id":"https://openalex.org/keywords/factor-xa-inhibitors","display_name":"factor Xa inhibitors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/factor-iia-inhibitors","display_name":"factor IIa inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":0.9190000295639038},{"id":"https://openalex.org/keywords/apixaban","display_name":"apixaban","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dabigatran","display_name":"dabigatran","score":0.9980000257492065},{"id":"https://openalex.org/keywords/edoxaban","display_name":"edoxaban","score":1.0},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.7070000171661377},{"id":"https://openalex.org/keywords/recurrent-venous-thromboembolism","display_name":"recurrent venous thromboembolism","score":0.9739999771118164},{"id":"https://openalex.org/keywords/indirect-comparison","display_name":"indirect comparison","score":0.6489999890327454},{"id":"https://openalex.org/keywords/anticoagulant-efficacy-and-safety","display_name":"anticoagulant efficacy and safety","score":0.6710000038146973},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C2780638905","wikidata":"https://www.wikidata.org/wiki/Q414462","display_name":"Apixaban","level":5,"score":0.9810621738433838},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.9679781198501587},{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.9415168762207031},{"id":"https://openalex.org/C2780290652","wikidata":"https://www.wikidata.org/wiki/Q21011234","display_name":"Edoxaban","level":5,"score":0.9290134906768799},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.912686824798584},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4170045852661133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.407380610704422},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36911606788635254},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.3262234330177307},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.18685302138328552},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.08948329091072083}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054556","descriptor_name":"Venous Thromboembolism","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1024/0301-1526/a000373","doi":"https://doi.org/10.1024/0301-1526/a000373","is_oa":false,"landing_page_url":"https://doi.org/10.1024/0301-1526/a000373","pdf_url":null,"source":{"id":"https://openalex.org/S4210188602","display_name":"VASA","issn_l":"0301-1526","issn":["0301-1526","1664-2872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319871","host_organization_name":"Hogrefe Verlag","host_organization_lineage":["https://openalex.org/P4310319871"],"host_organization_lineage_names":["Hogrefe Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasa","raw_type":"journal-article"},{"id":"pmid:25147012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25147012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VASA. Zeitschrift fur Gefasskrankheiten","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024232617","https://openalex.org/W2113561246","https://openalex.org/W2211181735","https://openalex.org/W2886823706","https://openalex.org/W2557690012","https://openalex.org/W4311733619","https://openalex.org/W2132914580","https://openalex.org/W2171381436","https://openalex.org/W6958810521","https://openalex.org/W4211021455"],"abstract_inverted_index":{"BACKGROUND:":[0],"For":[1],"decades,":[2],"heparins":[3],"and":[4,25,49,85,88,97,104,113,138,145,162,170,188,205,207,221,243,259,264,302,317],"vitamin":[5],"K":[6],"antagonists":[7],"(VKAs)":[8],"have":[9],"been":[10],"the":[11,40,52,79,94,100,125,209,248,272,290,314,319],"gold":[12],"standards":[13],"in":[14,78,93,99,271,289],"therapy":[15],"of":[16,22,34,237,247,274,282,292,304,311],"venous":[17],"thromboembolism":[18],"(VTE).":[19],"The":[20,32,121,195],"advent":[21],"factor":[23],"IIa":[24],"Xa":[26],"inhibitors":[27],"provides":[28],"new":[29,43],"therapeutic":[30,315],"options.":[31],"aim":[33],"this":[35],"analysis":[36],"is":[37,59],"to":[38,119,130],"compare":[39],"currently":[41],"available":[42],"oral":[44],"anticoagulants":[45],"(NOACs)":[46],"with":[47,54,91,279],"VKAs":[48],"also":[50],"indirectly":[51],"NOACs":[53,126,137,258,267,312],"each":[55],"other,":[56],"as":[57,269,276,300],"it":[58],"unlikely":[60],"that":[61],"a":[62],"head-to-head":[63],"comparison":[64,123],"will":[65],"ever":[66],"be":[67],"available.":[68],"PATIENTS":[69],"AND":[70],"METHODS:":[71],"In":[72],"total,":[73],"27,024":[74],"patients":[75],"were":[76,107,140,230],"included":[77],"RE-COVER,":[80],"RE-COVER":[81],"II,":[82],"EINSTEIN":[83],"DVT":[84],"PE,":[86],"AMPLIFY":[87],"HOKUSAI":[89],"studies":[90],"13,511":[92],"VKA":[95,139,277],"arm":[96],"13,513":[98],"NOAC":[101],"arm.":[102],"Efficacy":[103],"safety":[105],"endpoints":[106],"assessed":[108],"by":[109,151,155,175],"relative":[110,118],"risks":[111],"(RR)":[112],"absolute":[114],"risk":[115,281,291],"reductions":[116],"(ARR)":[117],"VKA.":[120],"indirect":[122],"between":[124,136,232],"was":[127,148,200],"performed":[128,253],"according":[129],"ISPOR":[131],"guidelines.":[132],"RESULTS:":[133],"No":[134],"differences":[135,229,288],"found":[141,231],"regarding":[142],"recurrent":[143],"VTE":[144,275],"death.":[146],"Bleeding":[147],"significantly":[149],"reduced":[150,235,280],"NOACs:":[152],"major":[153,169,198,238],"bleeding":[154,174,199,211,239,250,283,295],"rivaroxaban":[156,204,263],"(RR":[157,164,177,183,190],"0.55;":[158],"0.38":[159],"-":[160,167,180,186,193],"0.81)":[161],"apixaban":[163,182,252],"0.31;":[165],"0.17":[166],"0.55);":[168],"clinically":[171,293],"relevant":[172,294],"non-major":[173],"dabigatran":[176,242,260],"0.63;":[178],"0.51":[179],"0.77),":[181],"0.44;":[184],"0.36":[185],"0.55)":[187],"edoxaban":[189],"0.81;":[191],"0.71":[192],"0.93).":[194],"ARR":[196],"for":[197,203,208,215,219,224,321],"1":[201],"%":[202,214,218,223],"apixaban;":[206],"composite":[210,249],"endpoint":[212],"3.2":[213],"dabigatran,":[216],"5.4":[217],"apixaban,":[220],"1.9":[222],"edoxaban.":[225,244,265],"Regarding":[226,245],"efficacy,":[227],"no":[228],"NOACs.":[233],"Apixaban":[234],"incidence":[236],"more":[240],"than":[241,255,262],"occurrence":[246],"endpoint,":[251],"better":[254,261],"all":[256],"other":[257],"CONCLUSIONS:":[266],"are":[268,306],"efficient":[270],"treatment":[273],"but":[278,309],"complications.":[284],"Indirect":[285],"comparisons":[286],"indicate":[287],"events.":[296],"Important":[297],"issues":[298],"such":[299],"monitoring":[301],"reversal":[303],"anticoagulation":[305],"still":[307],"unresolved,":[308],"introduction":[310],"increased":[313],"spectrum":[316],"thereby":[318],"potential":[320],"individualized":[322],"therapy.":[323]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":12},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
