{"id":"https://openalex.org/W2050928935","doi":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","title":"Involvement of purine nucleotide synthetic pathways in gonadotropin-induced meiotic maturation in mouse cumulus cell-enclosed oocytes","display_name":"Involvement of purine nucleotide synthetic pathways in gonadotropin-induced meiotic maturation in mouse cumulus cell-enclosed oocytes","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2050928935","doi":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","mag":"2050928935","pmid":"https://pubmed.ncbi.nlm.nih.gov/9021747"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","doi":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen M. Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen M. Downs","raw_affiliation_strings":["Department of Biology, Marquette University, Milwaukee, Wisconsin 53201-1881, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Marquette University, Milwaukee, Wisconsin 53201-1881, USA","institution_ids":["https://openalex.org/I102461120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102461120"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":1.9711,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.84839129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"46","issue":"2","first_page":"155","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/purine-nucleotide-metabolism","display_name":"purine nucleotide metabolism","score":0.7829999923706055},{"id":"https://openalex.org/keywords/de-novo-purine-synthesis","display_name":"de novo purine synthesis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9089999794960022},{"id":"https://openalex.org/keywords/germinal-vesicle-breakdown","display_name":"germinal vesicle breakdown","score":0.9089999794960022},{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.9169999957084656},{"id":"https://openalex.org/keywords/azaserine","display_name":"azaserine","score":0.6759999990463257},{"id":"https://openalex.org/keywords/aminopterin","display_name":"aminopterin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/aica-riboside","display_name":"AICA riboside","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mycophenolic-acid","display_name":"mycophenolic acid","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9095538854598999},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.6768614649772644},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.6267896294593811},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.5893120169639587},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5358157753944397},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.532608151435852},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5290690064430237},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3744792342185974},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3245449662208557},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24451413750648499},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.20782828330993652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17819154262542725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08592277765274048},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0850294828414917},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.07916480302810669},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000620","descriptor_name":"Aminoimidazole Carboxamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001377","descriptor_name":"Azaserine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009866","descriptor_name":"Oogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","doi":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.0.co;2-p","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.3.co;2-v","doi":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.3.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2795(199702)46:2<155::aid-mrd6>3.3.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:9021747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9021747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6920419832","display_name":"PURINES AND THE MAINTENANCE OF MEIOTIC ARREST","funder_award_id":"R01HD025291","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W9686781","https://openalex.org/W129487543","https://openalex.org/W1489790705","https://openalex.org/W1554112144","https://openalex.org/W1565550299","https://openalex.org/W1567144309","https://openalex.org/W1570911552","https://openalex.org/W1600339587","https://openalex.org/W1625866499","https://openalex.org/W1702423934","https://openalex.org/W1798418173","https://openalex.org/W1938843555","https://openalex.org/W1966879127","https://openalex.org/W1974265269","https://openalex.org/W1980489970","https://openalex.org/W1987337899","https://openalex.org/W1987372597","https://openalex.org/W1987420815","https://openalex.org/W1991257353","https://openalex.org/W1993444917","https://openalex.org/W1995523846","https://openalex.org/W1997800433","https://openalex.org/W2007904803","https://openalex.org/W2009509515","https://openalex.org/W2010516606","https://openalex.org/W2013392328","https://openalex.org/W2015977730","https://openalex.org/W2035234400","https://openalex.org/W2036725137","https://openalex.org/W2038227076","https://openalex.org/W2049717556","https://openalex.org/W2050624552","https://openalex.org/W2053299519","https://openalex.org/W2053470850","https://openalex.org/W2056860655","https://openalex.org/W2062955020","https://openalex.org/W2063372310","https://openalex.org/W2065705538","https://openalex.org/W2083375256","https://openalex.org/W2095727423","https://openalex.org/W2120165254","https://openalex.org/W2122522938","https://openalex.org/W2123255145","https://openalex.org/W2123509576","https://openalex.org/W2126565615","https://openalex.org/W2131553631","https://openalex.org/W2141633603","https://openalex.org/W2148996094","https://openalex.org/W2149266257","https://openalex.org/W2154737050","https://openalex.org/W2164015668","https://openalex.org/W2170530908","https://openalex.org/W2181781305","https://openalex.org/W2409541854","https://openalex.org/W2412846926","https://openalex.org/W3022081482"],"related_works":["https://openalex.org/W2120165254","https://openalex.org/W2009520932","https://openalex.org/W2089418877","https://openalex.org/W2057684436","https://openalex.org/W2034342456","https://openalex.org/W1973011556","https://openalex.org/W1594898681","https://openalex.org/W2149021404","https://openalex.org/W2056860655","https://openalex.org/W2011348946"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,65,105,145,239],"carried":[3],"out":[4],"to":[5,147,217,232,241],"test":[6],"the":[7,69,84,96,108,129,152,201,223,233,259,283,291,299,309,318],"hypothesis":[8],"that":[9,208,280,301,316],"purine":[10,173,224,242,286,302],"nucleotide-generating":[11,303],"pathways":[12,304],"are":[13,305],"required":[14],"for":[15,151],"ligand-stimulated":[16],"oocyte":[17],"maturation":[18,179],"in":[19,34,180,258,275,282,308],"meiotically":[20],"arrested":[21],"cumulus":[22],"cell-enclosed":[23],"oocytes.":[24,189],"Oocytes":[25],"from":[26],"hormonally":[27],"primed,":[28],"immature":[29],"mice":[30],"were":[31,126],"cultured":[32],"overnight":[33],"Eagle's":[35],"minimum":[36],"essential":[37],"medium":[38],"containing":[39],"dibutyryl":[40],"cyclic":[41],"AMP":[42],"(dbcAMP)":[43],"(to":[44],"maintain":[45,148],"meiotic":[46,149,313],"arrest),":[47],"plus":[48],"either":[49,67,80,317],"mycophenolic":[50],"acid":[51],"or":[52,73,124,261,321],"alanosine":[53],"(inhibitors":[54],"of":[55,71,81,89,98,103,141,166,172,192,203,235,263,272,285,294],"guanyl":[56],"and":[57,169,215,250,315],"adenyl":[58],"nucleotide":[59,118,327],"production,":[60],"respectively).":[61],"Follicle-stimulating":[62],"hormone":[63],"(FSH)":[64],"added":[66],"at":[68,228],"outset":[70],"culture":[72,154],"after":[74],"a":[75,206,229],"3-hr":[76,109],"preincubation":[77,110,134],"period.":[78,155],"Under":[79],"these":[82],"conditions,":[83],"inhibitors":[85,171],"suppressed":[86,254],"FSH":[87,99,139,238],"induction":[88,140],"germinal":[90],"vesicle":[91],"breakdown":[92],"(GVB).":[93],"In":[94],"addition,":[95],"potency":[97],"as":[100,121],"an":[101],"inducer":[102],"GVB":[104,142],"reduced":[106],"following":[107],"period,":[111],"but":[112,183],"this":[113,163,326],"could":[114,160,197],"be":[115,198,210],"prevented":[116],"if":[117],"precursors":[119],"such":[120],"hypoxanthine,":[122,249],"guanosine,":[123],"adenosine":[125],"included":[127],"during":[128],"first":[130],"3":[131],"hr.":[132],"Furthermore,":[133],"had":[135,184],"little":[136,185],"effect":[137,165,186,191,293],"on":[138,187,194],"when":[143],"hypoxanthine":[144],"used":[146],"arrest":[150],"entire":[153],"The":[156,190],"phosphodiesterase":[157],"inhibitor":[158],"3-isobutyl-1-methylxanthine,":[159],"not":[161,289],"mimic":[162],"protective":[164],"hypoxanthine.":[167],"Azaserine":[168],"aminopterin,":[170,248],"de":[174,225,243,255,319],"novo":[175,226,244,256,320],"synthesis,":[176,245],"blocked":[177],"hormone-triggered":[178],"dbcAMP-arrested":[181],"oocytes,":[182],"hypoxanthine-arrested":[188],"azaserine":[193,236],"dbcAMP-treated":[195],"oocytes":[196],"reversed":[199],"by":[200,213],"inclusion":[202],"AICA":[204,251],"riboside,":[205],"compound":[207],"can":[209,221,324],"taken":[211],"up":[212],"cells":[214],"phosphorylated":[216],"form":[218],"AICAR,":[219],"which":[220],"enter":[222],"pathway":[227,323],"point":[230],"distal":[231],"sites":[234],"inhibition.":[237],"stimulatory":[240],"while":[246],"azaserine,":[247],"riboside":[252],"all":[253],"synthesis":[257],"presence":[260],"absence":[262],"FSH,":[264],"with":[265],"dbcAMP":[266],"having":[267],"no":[268],"effect.":[269],"HPLC":[270],"analysis":[271],"14C-hypoxanthine":[273],"metabolism":[274,287],"oocyte-cumulus":[276],"cell":[277],"complexes":[278],"revealed":[279],"changes":[281],"pattern":[284],"did":[288],"mediate":[290],"meiosis-inducing":[292],"FSH.":[295],"These":[296],"data":[297],"support":[298],"conclusion":[300],"vital":[306],"participants":[307],"mechanism(s)":[310],"regulating":[311],"hormone-induced":[312],"maturation,":[314],"salvage":[322],"fulfill":[325],"requirement.":[328]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}