{"id":"https://openalex.org/W2050898703","doi":"https://doi.org/10.1016/j.bcmd.2011.11.006","title":"Treatment of the bone marrow failure in Fanconi anemia patients with danazol","display_name":"Treatment of the bone marrow failure in Fanconi anemia patients with danazol","publication_year":2011,"publication_date":"2011-12-16","ids":{"openalex":"https://openalex.org/W2050898703","doi":"https://doi.org/10.1016/j.bcmd.2011.11.006","mag":"2050898703","pmid":"https://pubmed.ncbi.nlm.nih.gov/22178060"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcmd.2011.11.006","doi":"https://doi.org/10.1016/j.bcmd.2011.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcmd.2011.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S183588319","display_name":"Blood Cells Molecules and Diseases","issn_l":"1079-9796","issn":["1079-9796","1096-0961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cells, Molecules, and Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076703927","display_name":"Kathrin Scheckenbach","orcid":"https://orcid.org/0000-0002-2899-4487","observed_orcids":["https://orcid.org/0000-0002-2899-4487"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Scheckenbach","raw_affiliation_strings":["Otorhinolaryngology (HNO), Heinrich Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology (HNO), Heinrich Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080449822","display_name":"Mary Anne M. Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mary Morgan","raw_affiliation_strings":["Department of Paediatric Haematology / Oncology, University Hospital Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Haematology / Oncology, University Hospital Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083719402","display_name":"Judith Filger-Brillinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Judith Filger-Brillinger","raw_affiliation_strings":["Pediatric Hematology/Oncology, Children's Hospital, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology/Oncology, Children's Hospital, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011049804","display_name":"Matthias Sandmann","orcid":"https://orcid.org/0009-0008-8785-9999","observed_orcids":["https://orcid.org/0009-0008-8785-9999"]},"institutions":[{"id":"https://openalex.org/I4210120381","display_name":"Helios Universit\u00e4tsklinikum Wuppertal","ror":"https://ror.org/02r8sh830","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120381"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Sandmann","raw_affiliation_strings":["Internal Medicine, Petrus Hospital, Wuppertal, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Petrus Hospital, Wuppertal, Germany","institution_ids":["https://openalex.org/I4210120381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048546204","display_name":"Bruce Strimling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Strimling","raw_affiliation_strings":["Oregon Medical Group, Crescent Medical Clinic, Eugene, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Medical Group, Crescent Medical Clinic, Eugene, OR, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024624611","display_name":"Wolfram G. Scheurlen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119321","display_name":"Cnopf\u00b4sche Kinderklinik","ror":"https://ror.org/02ccsj972","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210119321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfram Scheurlen","raw_affiliation_strings":["Cnopf \u0301sche Kinderklinik, N\u00fcrnberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cnopf \u0301sche Kinderklinik, N\u00fcrnberg, Germany","institution_ids":["https://openalex.org/I4210119321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003985566","display_name":"Detlev Schindler","orcid":"https://orcid.org/0000-0003-2451-8165","observed_orcids":["https://orcid.org/0000-0003-2451-8165"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Detlev Schindler","raw_affiliation_strings":["Human Genetics, University of W\u00fcrzburg, W\u00fcrzburg, Germany","Human Genetics, University of Wurzburg, Wurzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Human Genetics, University of Wurzburg, Wurzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107929506","display_name":"Ulrich G\u00f6bel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich G\u00f6bel","raw_affiliation_strings":["ESPED Surveillance Unit, UKD, Heinrich Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ESPED Surveillance Unit, UKD, Heinrich Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017322730","display_name":"Helmut Hanenberg","orcid":"https://orcid.org/0000-0003-0451-2735","observed_orcids":["https://orcid.org/0000-0003-0451-2735"]},"institutions":[{"id":"https://openalex.org/I2802740592","display_name":"Riley Hospital for Children","ror":"https://ror.org/03vzvbw58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Helmut Hanenberg","raw_affiliation_strings":["Otorhinolaryngology (HNO), Heinrich Heine University, D\u00fcsseldorf, Germany","Pediatric Hematology/Oncology, Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology (HNO), Heinrich Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Pediatric Hematology/Oncology, Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5017322730"],"corresponding_institution_ids":["https://openalex.org/I2802740592","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I44260953"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":1.8768,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.86412027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"48","issue":"2","first_page":"128","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":1.0},{"id":"https://openalex.org/keywords/bone-marrow-failure","display_name":"bone marrow failure","score":0.9800000190734863},{"id":"https://openalex.org/keywords/danazol","display_name":"danazol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/synthetic-androgens","display_name":"synthetic androgens","score":0.8930000066757202},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.6859999895095825},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.6029999852180481},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.996999979019165},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.6129999756813049},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2777416354","wikidata":"https://www.wikidata.org/wiki/Q419652","display_name":"Danazol","level":3,"score":0.968567967414856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8227733373641968},{"id":"https://openalex.org/C2778124228","wikidata":"https://www.wikidata.org/wiki/Q845779","display_name":"Fanconi anemia","level":4,"score":0.6744067668914795},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.637914776802063},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5513573884963989},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5473268032073975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48744872212409973},{"id":"https://openalex.org/C2780525284","wikidata":"https://www.wikidata.org/wiki/Q7882181","display_name":"Bone marrow failure","level":4,"score":0.48362651467323303},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4683871567249298},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.438708633184433},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.4199267029762268},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.22704243659973145},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08311370015144348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06595340371131897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003613","descriptor_name":"Danazol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005199","descriptor_name":"Fanconi Anemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bcmd.2011.11.006","doi":"https://doi.org/10.1016/j.bcmd.2011.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcmd.2011.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S183588319","display_name":"Blood Cells Molecules and Diseases","issn_l":"1079-9796","issn":["1079-9796","1096-0961"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cells, Molecules, and Diseases","raw_type":"journal-article"},{"id":"pmid:22178060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22178060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood cells, molecules & diseases","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W50187013","https://openalex.org/W1763675371","https://openalex.org/W1920573557","https://openalex.org/W1964418456","https://openalex.org/W1968759947","https://openalex.org/W1971541989","https://openalex.org/W1981101052","https://openalex.org/W1987177883","https://openalex.org/W1992511544","https://openalex.org/W1998048803","https://openalex.org/W2000067413","https://openalex.org/W2002122727","https://openalex.org/W2003058744","https://openalex.org/W2003562932","https://openalex.org/W2005548022","https://openalex.org/W2012102598","https://openalex.org/W2020481544","https://openalex.org/W2030215141","https://openalex.org/W2032363243","https://openalex.org/W2034668175","https://openalex.org/W2046140488","https://openalex.org/W2052215590","https://openalex.org/W2052822223","https://openalex.org/W2064587482","https://openalex.org/W2065417936","https://openalex.org/W2072515174","https://openalex.org/W2077356215","https://openalex.org/W2084194591","https://openalex.org/W2084937921","https://openalex.org/W2090643077","https://openalex.org/W2105862823","https://openalex.org/W2116544264","https://openalex.org/W2119575206","https://openalex.org/W2150608317","https://openalex.org/W2162345139","https://openalex.org/W2171183678","https://openalex.org/W2252370360","https://openalex.org/W2593467271","https://openalex.org/W4236684906","https://openalex.org/W4240884067","https://openalex.org/W6638166880"],"related_works":["https://openalex.org/W2979342251","https://openalex.org/W127564532","https://openalex.org/W2162588161","https://openalex.org/W2341279336","https://openalex.org/W2100139847","https://openalex.org/W7117361938","https://openalex.org/W2429578362","https://openalex.org/W2181652344","https://openalex.org/W2065619758","https://openalex.org/W2419884735"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}