{"id":"https://openalex.org/W2050872235","doi":"https://doi.org/10.1016/0378-1119(93)90150-2","title":"A ribonuclease S-peptide antagonist discovered with a bacteriophage display library","display_name":"A ribonuclease S-peptide antagonist discovered with a bacteriophage display library","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2050872235","doi":"https://doi.org/10.1016/0378-1119(93)90150-2","mag":"2050872235","pmid":"https://pubmed.ncbi.nlm.nih.gov/8508958"},"language":"en","primary_location":{"id":"doi:10.1016/0378-1119(93)90150-2","doi":"https://doi.org/10.1016/0378-1119(93)90150-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-1119(93)90150-2","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"George P. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George P. Smith","raw_affiliation_strings":["Division of Biological Sciences, University of Missouri, Columbia 65211","Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri, Columbia 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009113137","display_name":"David Schultz","orcid":"https://orcid.org/0000-0002-0105-2721","observed_orcids":["https://orcid.org/0000-0002-0105-2721"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Schultz","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA. Tel. (203)432-5794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA. Tel. (203)432-5794","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057051999","display_name":"John Edward Ladbury","orcid":"https://orcid.org/0000-0002-6328-7200","observed_orcids":["https://orcid.org/0000-0002-6328-7200"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Ladbury","raw_affiliation_strings":["Department of Chemistry, Yale University, New Haven, CT 06511, USA. Tel. (203)432-5206","Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA. Tel. (203)432-5794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Yale University, New Haven, CT 06511, USA. Tel. (203)432-5206","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA. Tel. (203)432-5794","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":8.7961,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.99001557,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"128","issue":"1","first_page":"37","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-protein","display_name":"S protein","score":0.7440000176429749},{"id":"https://openalex.org/keywords/bovine-pancreatic-ribonuclease-a","display_name":"bovine pancreatic ribonuclease","score":0.9399999976158142},{"id":"https://openalex.org/keywords/peptide-antagonists","display_name":"peptide antagonists","score":0.6790000200271606},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.6129999756813049},{"id":"https://openalex.org/keywords/peptide-binding","display_name":"peptide binding","score":0.3720000088214874},{"id":"https://openalex.org/keywords/enzyme-reactivation","display_name":"enzyme reactivation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9396847486495972},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.7010189294815063},{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.6938472390174866},{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.5708295106887817},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.4938831925392151},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4937489926815033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41933396458625793},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4153191149234772},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3426235318183899},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3400689959526062},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33875805139541626},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.24135735630989075},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.16537383198738098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15737178921699524},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15542390942573547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08760690689086914},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0796327292919159}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0378-1119(93)90150-2","doi":"https://doi.org/10.1016/0378-1119(93)90150-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0378-1119(93)90150-2","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},{"id":"pmid:8508958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8508958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3480645253","display_name":null,"funder_award_id":"GM 41478","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4548276915","display_name":"EPITOPE DISCOVERY--NEW ROUTE TO VACCINES","funder_award_id":"R01GM041478","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7275174480","display_name":"PHYSICOCHEMICAL STUDIES OF BIOCHEMICAL REACTIONS","funder_award_id":"R01GM004725","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7591340234","display_name":"CONSTRAINING BETA-TURN STRUCTURE IN MODEL IMMUNOGENS","funder_award_id":"R01AI023923","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1537264614","https://openalex.org/W1539795437","https://openalex.org/W1591942886","https://openalex.org/W1876115765","https://openalex.org/W1965123458","https://openalex.org/W1973322293","https://openalex.org/W1973815378","https://openalex.org/W1980388661","https://openalex.org/W1996427305","https://openalex.org/W2010649076","https://openalex.org/W2020357919","https://openalex.org/W2040608320","https://openalex.org/W2068519658","https://openalex.org/W2084429764","https://openalex.org/W2111286822","https://openalex.org/W2157124478","https://openalex.org/W2487395565"],"related_works":["https://openalex.org/W2014563093","https://openalex.org/W2383271351","https://openalex.org/W1484878541","https://openalex.org/W1600743409","https://openalex.org/W2365694555","https://openalex.org/W2043599176","https://openalex.org/W4388859595","https://openalex.org/W137338023","https://openalex.org/W314598552","https://openalex.org/W650040934"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}