{"id":"https://openalex.org/W2050758672","doi":"https://doi.org/10.1254/jphs.09048fp","title":"Obovatol Enhances Docetaxel-Induced Prostate and Colon Cancer Cell Death Through Inactivation of Nuclear Transcription Factor-\u03baB","display_name":"Obovatol Enhances Docetaxel-Induced Prostate and Colon Cancer Cell Death Through Inactivation of Nuclear Transcription Factor-\u03baB","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2050758672","doi":"https://doi.org/10.1254/jphs.09048fp","mag":"2050758672","pmid":"https://pubmed.ncbi.nlm.nih.gov/19834284"},"language":"en","primary_location":{"id":"doi:10.1254/jphs.09048fp","doi":"https://doi.org/10.1254/jphs.09048fp","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.09048fp","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/111/2/111_09048FP/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jphs/111/2/111_09048FP/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090088424","display_name":"So Yong Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So Yong Lee","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009626497","display_name":"Jin Suk Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Suk Cho","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087253555","display_name":"Dong Yeon Yuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Yeon Yuk","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111867158","display_name":"Dong Cheul Moon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Cheul Moon","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049902585","display_name":"Jae\u2010Kyung Jung","orcid":"https://orcid.org/0000-0002-0490-9663","observed_orcids":["https://orcid.org/0000-0002-0490-9663"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Kyung Jung","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102122592","display_name":"Hwan Soo Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hwan Soo Yoo","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Young Moon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Moon Lee","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037204409","display_name":"Sang\u2010Bae Han","orcid":"https://orcid.org/0000-0001-6656-6523","observed_orcids":["https://orcid.org/0000-0001-6656-6523"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Bae Han","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059501412","display_name":"Ki\u2010Wan Oh","orcid":"https://orcid.org/0000-0001-8054-9260","observed_orcids":["https://orcid.org/0000-0001-8054-9260"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Wan Oh","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007610160","display_name":"Jin Tae Hong","orcid":"https://orcid.org/0000-0002-6534-9575","observed_orcids":["https://orcid.org/0000-0002-6534-9575","https://orcid.org/0000-0003-0692-4469"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Tae Hong","raw_affiliation_strings":["College of Pharmacy and CBITRC, Chungbuk National University, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and CBITRC, Chungbuk National University, South Korea","institution_ids":["https://openalex.org/I163753206"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I163753206"],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":null,"fwci":1.0795,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.7721911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"111","issue":"2","first_page":"124","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.42899999022483826,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.42899999022483826,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.21410000324249268,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.09539999812841415,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obovatol","display_name":"obovatol","score":1.0},{"id":"https://openalex.org/keywords/magnolia-obovata","display_name":"Magnolia obovata","score":0.9620000123977661},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8519999980926514},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8999999761581421},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6290000081062317},{"id":"https://openalex.org/keywords/anti-apoptotic-proteins","display_name":"anti-apoptotic proteins","score":0.7269999980926514},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.8619329929351807},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.7525810599327087},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6503705382347107},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6478639245033264},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6310409307479858},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6263794898986816},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5954713821411133},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.5893773436546326},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5584417581558228},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5538967251777649},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5168088674545288},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5086208581924438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4711555242538452},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.42116862535476685},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4182090759277344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3012153208255768},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22687530517578125},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18220216035842896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08908107876777649}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010647","descriptor_name":"Phenyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010647","descriptor_name":"Phenyl Ethers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031566","descriptor_name":"Magnolia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1254/jphs.09048fp","doi":"https://doi.org/10.1254/jphs.09048fp","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.09048fp","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/111/2/111_09048FP/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:19834284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19834284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1d72ad15c4c54237a45dbc67e5504066","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1d72ad15c4c54237a45dbc67e5504066","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences, Vol 111, Iss 2, Pp 124-136 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1254/jphs.09048fp","doi":"https://doi.org/10.1254/jphs.09048fp","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.09048fp","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/111/2/111_09048FP/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2050758672.pdf","grobid_xml":"https://content.openalex.org/works/W2050758672.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W106047730","https://openalex.org/W1481925502","https://openalex.org/W1492606093","https://openalex.org/W1551533003","https://openalex.org/W1839238860","https://openalex.org/W1888783223","https://openalex.org/W1904788586","https://openalex.org/W1971284419","https://openalex.org/W1978770507","https://openalex.org/W1979959507","https://openalex.org/W1981895882","https://openalex.org/W1982785575","https://openalex.org/W1986320549","https://openalex.org/W1987867148","https://openalex.org/W1994508517","https://openalex.org/W1995513775","https://openalex.org/W1998246524","https://openalex.org/W2001333573","https://openalex.org/W2001723288","https://openalex.org/W2003082720","https://openalex.org/W2014742104","https://openalex.org/W2020754486","https://openalex.org/W2022428297","https://openalex.org/W2024824408","https://openalex.org/W2027686496","https://openalex.org/W2029916045","https://openalex.org/W2030611702","https://openalex.org/W2032531389","https://openalex.org/W2034269086","https://openalex.org/W2041889651","https://openalex.org/W2046056065","https://openalex.org/W2050020691","https://openalex.org/W2051433588","https://openalex.org/W2055333644","https://openalex.org/W2058120885","https://openalex.org/W2062921699","https://openalex.org/W2067176661","https://openalex.org/W2069121050","https://openalex.org/W2070205695","https://openalex.org/W2080070482","https://openalex.org/W2082575834","https://openalex.org/W2083623093","https://openalex.org/W2086941505","https://openalex.org/W2087973500","https://openalex.org/W2092038968","https://openalex.org/W2099854686","https://openalex.org/W2103562758","https://openalex.org/W2111047998","https://openalex.org/W2118247947","https://openalex.org/W2124076790","https://openalex.org/W2124279506","https://openalex.org/W2125943630","https://openalex.org/W2133482807","https://openalex.org/W2134994441","https://openalex.org/W2146681242","https://openalex.org/W2151837372","https://openalex.org/W2157312799","https://openalex.org/W2169597641","https://openalex.org/W2233087428","https://openalex.org/W2316386966","https://openalex.org/W4233628679"],"related_works":["https://openalex.org/W2020754486","https://openalex.org/W2953148071","https://openalex.org/W2157812932","https://openalex.org/W2389338019","https://openalex.org/W2055450660","https://openalex.org/W1990090167","https://openalex.org/W4292622248","https://openalex.org/W7048027678","https://openalex.org/W2053634917","https://openalex.org/W1979051848"],"abstract_inverted_index":{"Nuclear":[0],"transcription":[1],"factor-kappaB":[2],"(NF-kappaB)":[3],"is":[4,13],"constitutively":[5],"activated":[6],"in":[7,60,99,146,221],"prostate":[8,61],"and":[9,12,64,66,70,96,184,192,213],"colon":[10,67],"cancers":[11],"related":[14],"with":[15,76,136,178,225],"the":[16,82,100,125,130,137,150,187,222],"resistance":[17],"of":[18,41,57,102,120,160,176,189,211],"cancer":[19,36,51,62,68,103],"cells":[20,52],"against":[21,53],"chemotherapeutics.":[22,227],"Previously,":[23],"we":[24],"found":[25],"that":[26,201,215],"obovatol,":[27],"an":[28],"active":[29],"compound":[30],"isolated":[31],"from":[32],"Magnolia":[33],"obovata,":[34],"inhibited":[35,153],"cell":[37,104,148,164,170,190,204],"growth":[38,105,191,205],"through":[39,55,116,209],"inhibition":[40,56,101,113,139,188,206],"NF-kappaB":[42,58,154,161,193,212],"activity.":[43],"We":[44],"investigated":[45],"here":[46],"whether":[47],"obovatol":[48,88,177,202,216],"could":[49],"sensitize":[50],"docetaxel":[54],"activity":[59,194],"(LNCaP":[63],"PC-3)":[65],"(SW620":[69],"HCT116)":[71],"cells.":[72],"The":[73],"combination":[74,126,151,174,223],"treatment":[75,108,127,132,224],"each":[77,110],"drug":[78,111],"at":[79,232],"one":[80],"half":[81],"respective":[83],"IC(50)":[84],"dose":[85],"(5":[86],"microM":[87],"+":[89],"5":[90],"nM":[91],"docetaxel)":[92],"was":[93,114],"more":[94],"effective":[95],"significant":[97,118],"(60%-70%)":[98],"than":[106,144],"single":[107,131],"by":[109,124,207],"(20%-40%);":[112],"exerted":[115],"a":[117],"increase":[119],"apoptosis":[121],"induction":[122],"(60%-80%)":[123],"compared":[128],"to":[129],"(10%-30%).":[133],"Correlating":[134],"well":[135,157],"synergistic":[138],"(combination":[140],"indices":[141],"are":[142],"less":[143],"1":[145],"all":[147],"types),":[149],"significantly":[152],"activities":[155],"as":[156,158],"expression":[159],"target":[162],"apoptotic":[163],"death":[165,171],"proteins,":[166],"but":[167],"decreased":[168],"anti-apoptotic":[169],"proteins.":[172],"Similar":[173],"effects":[175],"other":[179,226],"chemotherapeutic":[180],"agents":[181],"(paclitaxel,":[182],"cisplatin,":[183],"doxorubicin)":[185],"on":[186],"were":[195],"also":[196],"found.":[197],"These":[198],"results":[199],"indicate":[200],"augments":[203],"chemotherapeutics":[208],"inactivation":[210],"suggest":[214],"may":[217],"have":[218],"therapeutic":[219],"advantages":[220],"[Supplementary":[228],"Figure:":[229],"available":[230],"only":[231],"http://dx.doi.org/10.1254/jphs.09048FP].":[233]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}