{"id":"https://openalex.org/W205050459","doi":"https://doi.org/10.1007/978-1-62703-188-2_18","title":"Management of High-Grade Prostatic Intraepithelial Neoplasia (HGPIN)","display_name":"Management of High-Grade Prostatic Intraepithelial Neoplasia (HGPIN)","publication_year":2012,"publication_date":"2012-10-17","ids":{"openalex":"https://openalex.org/W205050459","doi":"https://doi.org/10.1007/978-1-62703-188-2_18","mag":"205050459"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-62703-188-2_18","doi":"https://doi.org/10.1007/978-1-62703-188-2_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-188-2_18","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostate Cancer Diagnosis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2484046566","display_name":"Prostate Cancer Diagnosis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016168396","display_name":"Krishna A Ramaswamy","orcid":"https://orcid.org/0000-0002-7368-4429","observed_orcids":["https://orcid.org/0000-0002-7368-4429"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Ramaswamy","raw_affiliation_strings":["Division of Urologic Oncology, Department of Urology, New York University Langone Medical Center (NYULMC), 150 East 32nd Street, Suite 200, New York, NY, 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urologic Oncology, Department of Urology, New York University Langone Medical Center (NYULMC), 150 East 32nd Street, Suite 200, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011556876","display_name":"Herbert Lepor","orcid":"https://orcid.org/0000-0002-7839-835X","observed_orcids":["https://orcid.org/0000-0002-7839-835X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Lepor","raw_affiliation_strings":["Division of Urologic Oncology, Department of Urology, New York University Langone Medical Center (NYULMC), 150 East 32nd Street, Suite 200, New York, NY, 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urologic Oncology, Department of Urology, New York University Langone Medical Center (NYULMC), 150 East 32nd Street, Suite 200, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062397416","display_name":"Samir S. Taneja","orcid":"https://orcid.org/0000-0003-0887-8259","observed_orcids":["https://orcid.org/0000-0003-0887-8259"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samir S. Taneja","raw_affiliation_strings":["Division of Urologic Oncology, Department of Urology, New York University Langone Medical Center (NYULMC), 150 East 32nd Street, Suite 200, New York, NY, 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urologic Oncology, Department of Urology, New York University Langone Medical Center (NYULMC), 150 East 32nd Street, Suite 200, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I4210086933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062397416"],"corresponding_institution_ids":["https://openalex.org/I4210086933"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12712801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"241","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-prostatic-intraepithelial-neoplasia","display_name":"high-grade prostatic intraepithelial neoplasia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prostate-cancer-risk","display_name":"prostate cancer risk","score":0.7559999823570251},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.7450000047683716},{"id":"https://openalex.org/keywords/serum-psa","display_name":"serum PSA","score":0.5989999771118164},{"id":"https://openalex.org/keywords/localized-prostate-cancer","display_name":"localized prostate cancer","score":0.7630000114440918},{"id":"https://openalex.org/keywords/preventive-agents","display_name":"preventive agents","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2776456063","wikidata":"https://www.wikidata.org/wiki/Q15731388","display_name":"High-grade prostatic intraepithelial neoplasia","level":5,"score":0.8756128549575806},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.7274264693260193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5410354137420654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2050165832042694},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.19825130701065063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05737149715423584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-62703-188-2_18","doi":"https://doi.org/10.1007/978-1-62703-188-2_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-188-2_18","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostate Cancer Diagnosis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1965124667","https://openalex.org/W1966903123","https://openalex.org/W1968832277","https://openalex.org/W1977445310","https://openalex.org/W1980977659","https://openalex.org/W1981977212","https://openalex.org/W1982399356","https://openalex.org/W1986749657","https://openalex.org/W1988833150","https://openalex.org/W1988913944","https://openalex.org/W1999803087","https://openalex.org/W2002471362","https://openalex.org/W2006190057","https://openalex.org/W2008506920","https://openalex.org/W2009948823","https://openalex.org/W2011023034","https://openalex.org/W2017027982","https://openalex.org/W2018596412","https://openalex.org/W2021806359","https://openalex.org/W2023205876","https://openalex.org/W2024850963","https://openalex.org/W2025445728","https://openalex.org/W2025610386","https://openalex.org/W2026327944","https://openalex.org/W2028009279","https://openalex.org/W2030634970","https://openalex.org/W2032182556","https://openalex.org/W2041508773","https://openalex.org/W2043940833","https://openalex.org/W2052327228","https://openalex.org/W2054486077","https://openalex.org/W2058755542","https://openalex.org/W2061805003","https://openalex.org/W2064698733","https://openalex.org/W2067418223","https://openalex.org/W2071617133","https://openalex.org/W2073232639","https://openalex.org/W2077928657","https://openalex.org/W2083504451","https://openalex.org/W2089661954","https://openalex.org/W2097271805","https://openalex.org/W2104957990","https://openalex.org/W2107474944","https://openalex.org/W2112529553","https://openalex.org/W2122027058","https://openalex.org/W2126559236","https://openalex.org/W2127907032","https://openalex.org/W2128536507","https://openalex.org/W2133929387","https://openalex.org/W2140417252","https://openalex.org/W2143932786","https://openalex.org/W2147660153","https://openalex.org/W2150419644","https://openalex.org/W2155530804","https://openalex.org/W2156416751","https://openalex.org/W2157395875","https://openalex.org/W2161709125","https://openalex.org/W2164866499","https://openalex.org/W2314608765","https://openalex.org/W2398402167","https://openalex.org/W2416967238","https://openalex.org/W2422074834","https://openalex.org/W2793864840","https://openalex.org/W3135529189"],"related_works":["https://openalex.org/W2156416751","https://openalex.org/W7095144169","https://openalex.org/W2466971496","https://openalex.org/W4236912061","https://openalex.org/W222080169","https://openalex.org/W2025780646","https://openalex.org/W2089661954","https://openalex.org/W316334035","https://openalex.org/W3187739116","https://openalex.org/W2007827326"],"abstract_inverted_index":{"The":[0],"diagnosis":[1,175],"of":[2,13,30,53,77,85,107,131,152,176,180,191,200,212],"isolated":[3,54,71,134],"high-grade":[4],"prostatic":[5],"intraepithelial":[6],"neoplasia":[7],"(HGPIN)":[8],"is":[9,25,160,227],"based":[10],"on":[11,154],"findings":[12],"atypical":[14],"nuclei":[15],"in":[16,88,128,173,209],"cells":[17],"lining":[18],"architecturally":[19],"benign":[20],"glands.":[21],"This":[22,225],"premalignant":[23],"entity":[24],"associated":[26],"with":[27,70,100,133],"increased":[28,50],"risk":[29,76],"coexistent":[31],"cancer":[32,80],"or":[33],"delayed":[34],"progression":[35],"to":[36,45,102,162,171],"carcinoma.":[37],"Extended":[38],"biopsy":[39,145],"schemes":[40],"have":[41,73,149],"improved":[42],"the":[43,51,58,86,89,129,189,198,210,223,230,236],"ability":[44],"rule":[46],"out":[47],"concurrent":[48],"cancers,":[49],"detection":[52],"HGPIN,":[55],"and":[56,105,197,220,229],"removed":[57],"routine":[59],"necessity":[60],"for":[61,146],"immediate":[62],"repeat":[63,108],"biopsy.":[64,109,140],"Current":[65],"evidence":[66],"suggests":[67,121],"that":[68,167,184],"men":[69,132,147],"HGPIN":[72,135,153],"a":[74,174,177],"continued":[75],"developing":[78],"prostate":[79],"during":[81],"long-term":[82],"follow-up,":[83],"regardless":[84],"changes":[87],"serum":[90],"PSA":[91],"level.":[92],"To":[93],"date,":[94],"no":[95],"consensus":[96],"has":[97],"been":[98],"reached":[99],"regard":[101],"interval,":[103],"frequency,":[104],"technique":[106],"Our":[110],"multidisciplinary":[111],"group":[112],"at":[113,188],"New":[114],"York":[115],"University":[116],"Langone":[117],"Medical":[118],"Center":[119],"(NYULMC)":[120],"empiric":[122],"interval":[123],"biopsies":[124],"every":[125],"2\u20133":[126],"years":[127],"follow-up":[130],"found":[136],"by":[137,218,222],"extended":[138],"core":[139],"Some":[141],"authors":[142],"advocate":[143],"earlier":[144],"who":[148],"high":[150],"volume":[151],"initial":[155],"biopsy,":[156],"but":[157],"current":[158],"data":[159],"difficult":[161],"interpret.":[163],"Regardless,":[164],"we":[165],"believe":[166],"our":[168],"approach":[169],"appears":[170],"result":[172],"substantial":[178],"number":[179],"clinically":[181],"significant":[182],"cancers":[183],"are":[185],"still":[186],"organ-confined":[187],"time":[190],"pathological":[192],"review.":[193],"Nontoxic":[194],"preventive":[195],"agents":[196],"use":[199],"multiparametric":[201],"MRI":[202],"will":[203],"likely":[204],"emerge":[205],"as":[206,235],"useful":[207],"tools":[208],"management":[211],"HGPIN.":[213],"These":[214],"keywords":[215,231],"were":[216],"added":[217],"machine":[219],"not":[221],"authors.":[224],"process":[226],"experimental":[228],"may":[232],"be":[233],"updated":[234],"learning":[237],"algorithm":[238],"improves.":[239]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}