{"id":"https://openalex.org/W2050475290","doi":"https://doi.org/10.1371/journal.pone.0046568","title":"Interaction of TNF with Angiotensin II Contributes to Mitochondrial Oxidative Stress and Cardiac Damage in Rats","display_name":"Interaction of TNF with Angiotensin II Contributes to Mitochondrial Oxidative Stress and Cardiac Damage in Rats","publication_year":2012,"publication_date":"2012-10-09","ids":{"openalex":"https://openalex.org/W2050475290","doi":"https://doi.org/10.1371/journal.pone.0046568","mag":"2050475290","pmid":"https://pubmed.ncbi.nlm.nih.gov/23056347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3467241"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0046568","doi":"https://doi.org/10.1371/journal.pone.0046568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0046568","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046568&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046568&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029394382","display_name":"Nithya Mariappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nithya Mariappan","raw_affiliation_strings":["Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA. nithya06@lsu.edu","Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA. nithya06@lsu.edu","institution_ids":["https://openalex.org/I121820613"]},{"raw_affiliation_string":"Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, United States of America","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084217564","display_name":"Carrie M. Elks","orcid":"https://orcid.org/0000-0001-8521-7046","observed_orcids":["https://orcid.org/0000-0001-8521-7046"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie M. Elks","raw_affiliation_strings":["Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101057064","display_name":"Masudul Haque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masudul Haque","raw_affiliation_strings":["Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, United States of America","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074055562","display_name":"Joseph Francis","orcid":"https://orcid.org/0000-0002-9502-4579","observed_orcids":["https://orcid.org/0000-0002-9502-4579"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph Francis","raw_affiliation_strings":["Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, United States of America","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029394382","https://openalex.org/A5074055562"],"corresponding_institution_ids":["https://openalex.org/I121820613"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.7888,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.89519464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"e46568","last_page":"e46568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.11509999632835388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.07289999723434448,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.734000027179718},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cardiac-injury","display_name":"cardiac injury","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8159999847412109},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9599999785423279},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.7760000228881836},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8379999995231628},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8700000047683716},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.843999981880188},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mitochondrial-complex-activity","display_name":"mitochondrial complex activity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8479999899864197},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.8899999856948853},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6557012796401978},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.650190532207489},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.64482182264328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.631129264831543},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.612919807434082},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5681015849113464},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.504055380821228},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.48902949690818787},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4592042565345764},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.42455294728279114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4156605005264282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3777152895927429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28445273637771606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18883869051933289},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17824235558509827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14497724175453186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0046568","doi":"https://doi.org/10.1371/journal.pone.0046568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0046568","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046568&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3467241","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3467241","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23056347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23056347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.691.7862","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.691.7862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467241/pdf/pone.0046568.pdf","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lsu.edu:vetmed_pubs-1101","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lsu.edu/vetmed_pubs/101","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:repository.lsu.edu:vetmed_pubs-1101","doi":null,"is_oa":false,"landing_page_url":"https://repository.lsu.edu/vetmed_pubs/101","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:55a2307639bc431b9eb7007264bdc413","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/55a2307639bc431b9eb7007264bdc413","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 10, p e46568 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0046568","doi":"https://doi.org/10.1371/journal.pone.0046568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0046568","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046568&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G617029394","display_name":"Cytokine-induced Neurohumoral Excitation in Heart Failure","funder_award_id":"5r01hl080544-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G741327003","display_name":null,"funder_award_id":"R01-HL-080544","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2050475290.pdf","grobid_xml":"https://content.openalex.org/works/W2050475290.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W590561559","https://openalex.org/W1970527212","https://openalex.org/W1980073374","https://openalex.org/W1980611990","https://openalex.org/W1983361372","https://openalex.org/W1987090578","https://openalex.org/W1989300887","https://openalex.org/W1996971085","https://openalex.org/W1999400238","https://openalex.org/W2002390367","https://openalex.org/W2006244753","https://openalex.org/W2012777921","https://openalex.org/W2014771215","https://openalex.org/W2018211784","https://openalex.org/W2026629747","https://openalex.org/W2034252573","https://openalex.org/W2041880968","https://openalex.org/W2044651481","https://openalex.org/W2049054934","https://openalex.org/W2050019650","https://openalex.org/W2058185635","https://openalex.org/W2065219493","https://openalex.org/W2080661995","https://openalex.org/W2085233618","https://openalex.org/W2085660599","https://openalex.org/W2099281097","https://openalex.org/W2101514290","https://openalex.org/W2105812769","https://openalex.org/W2107865846","https://openalex.org/W2110880027","https://openalex.org/W2111704063","https://openalex.org/W2114215135","https://openalex.org/W2123503495","https://openalex.org/W2128382419","https://openalex.org/W2135058118","https://openalex.org/W2147737133","https://openalex.org/W2147931602","https://openalex.org/W2149413458","https://openalex.org/W2151691491","https://openalex.org/W2154818940","https://openalex.org/W2154937731","https://openalex.org/W2157836756","https://openalex.org/W2157944478","https://openalex.org/W2163954402","https://openalex.org/W2167437471","https://openalex.org/W2168975002","https://openalex.org/W2277966459","https://openalex.org/W2284577338","https://openalex.org/W2402288216","https://openalex.org/W2740213887"],"related_works":["https://openalex.org/W3177141378","https://openalex.org/W73287558","https://openalex.org/W2887141111","https://openalex.org/W1980611990","https://openalex.org/W4248495539","https://openalex.org/W2211545310","https://openalex.org/W3176133809","https://openalex.org/W2157944478","https://openalex.org/W16719775","https://openalex.org/W171802593"],"abstract_inverted_index":{"Recent":[0],"evidence":[1],"suggests":[2],"that":[3,116],"tumor":[4],"necrosis":[5],"factor":[6],"alpha":[7],"(TNF)":[8],"and":[9,29,37,76,86,100,107,127,136,142,154,156,177,198,203,209,223,228],"angiotensin":[10,102],"II":[11],"(ANGII)":[12],"induce":[13],"oxidative":[14],"stress":[15],"contribute":[16,230],"to":[17,32,40,231],"cardiovascular":[18],"disease":[19],"progression.":[20],"Here,":[21],"we":[22],"examined":[23],"whether":[24],"an":[25,178],"interaction":[26],"between":[27],"TNF":[28,51,54,89,118,167,186,215],"ANGII":[30],"contributes":[31],"altered":[33],"cardiac":[34,42,196,232],"mitochondrial":[35,87,150,157,193,221,242,249],"biogenesis":[36,208],"ATP":[38],"production":[39,122,138],"cause":[41],"damage":[43],"in":[44,110,133,145,161,171,174,180,251],"rats.":[45,114],"Rats":[46,73,115],"received":[47,117],"intraperitoneal":[48],"injections":[49],"of":[50,94,113,124,140,149,201,220,238,241],"(30":[52],"\u00b5g/kg),":[53],"+":[55],"losartan":[56],"(LOS,":[57],"1":[58,104],"mg/kg),":[59],"or":[60],"vehicle":[61],"for":[62,80,248],"5":[63],"days.":[64],"Left":[65],"ventricular":[66],"(LV)":[67],"function":[68,210],"was":[69],"measured":[70],"using":[71],"echocardiography.":[72],"were":[74,159],"sacrificed":[75],"LV":[77,112],"tissues":[78],"removed":[79],"gene":[81,243],"expression,":[82,244],"electron":[83],"paramagnetic":[84],"resonance":[85],"assays.":[88],"administration":[90,168,187],"significantly":[91],"increased":[92,121,137,224],"expression":[93,200],"the":[95,101,111,134,239],"NADPH":[96,204],"oxidase":[97,205],"subunit,":[98],"gp91phox,":[99],"type":[103],"receptor":[105],"(AT-1R)":[106],"decreased":[108,199],"eNOS":[109],"only":[119],"had":[120],"rates":[123,139],"superoxide,":[125],"peroxynitrite":[126],"total":[128],"reactive":[129],"oxygen":[130],"species":[131],"(ROS)":[132],"cytosol":[135],"superoxide":[141],"hydrogen":[143],"peroxide":[144],"mitochondria.":[146],"Decreased":[147],"activities":[148],"complexes":[151],"I,":[152],"II,":[153],"III":[155],"genes":[158,222],"observed":[160],"rats":[162,252],"given":[163,253],"TNF.":[164,254],"In":[165],"addition,":[166],"also":[169],"resulted":[170],"a":[172],"decrease":[173],"fractional":[175],"shortening":[176],"increase":[179],"Tei":[181],"index,":[182],"suggesting":[183,245],"diastolic":[184],"dysfunction.":[185],"with":[188],"concomitant":[189],"LOS":[190],"treatment":[191],"attenuated":[192],"damage,":[194],"restored":[195],"function,":[197],"AT1-R":[202],"subunits.":[206],"Mitochondrial":[207],"is":[211],"severely":[212],"impaired":[213],"by":[214,218],"as":[216],"evidenced":[217],"downregulation":[219,240],"free":[225],"radical":[226],"production,":[227],"may":[229],"damage.":[233],"These":[234],"defects":[235],"are":[236],"independent":[237],"novel":[246],"mechanisms":[247],"dysfunction":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}