{"id":"https://openalex.org/W2050467335","doi":"https://doi.org/10.1371/journal.pone.0011401","title":"NAD(P)H Quinone Oxidoreductase Protects TAp63\u03b3 from Proteasomal Degradation and Regulates TAp63\u03b3-Dependent Growth Arrest","display_name":"NAD(P)H Quinone Oxidoreductase Protects TAp63\u03b3 from Proteasomal Degradation and Regulates TAp63\u03b3-Dependent Growth Arrest","publication_year":2010,"publication_date":"2010-06-30","ids":{"openalex":"https://openalex.org/W2050467335","doi":"https://doi.org/10.1371/journal.pone.0011401","mag":"2050467335","pmid":"https://pubmed.ncbi.nlm.nih.gov/20613985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2894944"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0011401","doi":"https://doi.org/10.1371/journal.pone.0011401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011401","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011401&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011401&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084857809","display_name":"Oshrat Hershkovitz\u2010Rokah","orcid":"https://orcid.org/0000-0003-4685-0679","observed_orcids":["https://orcid.org/0000-0003-4685-0679"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oshrat Hershkovitz Rokah","raw_affiliation_strings":["Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058355502","display_name":"Ofer Shpilberg","orcid":"https://orcid.org/0000-0003-4463-7647","observed_orcids":["https://orcid.org/0000-0003-4463-7647"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ofer Shpilberg","raw_affiliation_strings":["Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel","Institute of Hematology, Beilinson Hospital, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Institute of Hematology, Beilinson Hospital, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2800389475"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019342078","display_name":"Galit Granot","orcid":"https://orcid.org/0000-0002-3377-6521","observed_orcids":["https://orcid.org/0000-0002-3377-6521"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Galit Granot","raw_affiliation_strings":["Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah-Tikva, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019342078"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.1367,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.78382575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"6","first_page":"e11401","last_page":"e11401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.049800001084804535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase-1","display_name":"NAD(P)H:quinone oxidoreductase 1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/p63","display_name":"p63","score":0.8899999856948853},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.9580000042915344},{"id":"https://openalex.org/keywords/p53-family","display_name":"p53 family","score":0.6919999718666077},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.621999979019165},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8730000257492065},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.718999981880188},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nqo1-polymorphism","display_name":"NQO1 polymorphism","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.7162441611289978},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.580521821975708},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5256810188293457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.363364040851593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2987043261528015},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28991031646728516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25528475642204285}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0011401","doi":"https://doi.org/10.1371/journal.pone.0011401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011401","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011401&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2894944","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2894944","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20613985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20613985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.354.6422","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.6422","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a4/4c/PLoS_One_2010_Jun_30_5(6)_e11401.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:631588583aa7433abb0a66d986c1f672","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/631588583aa7433abb0a66d986c1f672","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 6, p e11401 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0011401","doi":"https://doi.org/10.1371/journal.pone.0011401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011401","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011401&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2050467335.pdf","grobid_xml":"https://content.openalex.org/works/W2050467335.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1534987406","https://openalex.org/W1925723678","https://openalex.org/W1970200236","https://openalex.org/W1972334859","https://openalex.org/W1977379434","https://openalex.org/W1990357305","https://openalex.org/W1990780198","https://openalex.org/W1993414761","https://openalex.org/W2014938226","https://openalex.org/W2017998287","https://openalex.org/W2024568523","https://openalex.org/W2034882416","https://openalex.org/W2040121494","https://openalex.org/W2043886024","https://openalex.org/W2053743600","https://openalex.org/W2057431251","https://openalex.org/W2059021008","https://openalex.org/W2061015706","https://openalex.org/W2062364714","https://openalex.org/W2063131548","https://openalex.org/W2066172043","https://openalex.org/W2072368664","https://openalex.org/W2073638338","https://openalex.org/W2074545297","https://openalex.org/W2081870581","https://openalex.org/W2083358720","https://openalex.org/W2085813943","https://openalex.org/W2099952208","https://openalex.org/W2100810085","https://openalex.org/W2100901254","https://openalex.org/W2101185543","https://openalex.org/W2111303550","https://openalex.org/W2112881364","https://openalex.org/W2118508998","https://openalex.org/W2141139321","https://openalex.org/W2149966409","https://openalex.org/W2150507760","https://openalex.org/W2152623217","https://openalex.org/W2165943742","https://openalex.org/W2167669999","https://openalex.org/W2313048860"],"related_works":["https://openalex.org/W7097497521","https://openalex.org/W2053743600","https://openalex.org/W2399197476","https://openalex.org/W2024568523","https://openalex.org/W42143944","https://openalex.org/W2072368664","https://openalex.org/W2099952208","https://openalex.org/W2057431251","https://openalex.org/W2085619020","https://openalex.org/W2100810085"],"abstract_inverted_index":{"BACKGROUND:":[0],"p63":[1,11,227],"is":[2,12,130,138,207],"a":[3,142,216,233],"member":[4],"of":[5,52,70,94,112,191,241],"the":[6,23,28,34,50,68,71,92,98,110,131,157,208,224,239],"p53":[7,72,102],"transcription":[8,134],"factor":[9],"family.":[10],"expressed":[13],"from":[14,175],"two":[15],"promoters":[16],"resulting":[17],"in":[18,108,144,238],"proteins":[19],"with":[20,89,120,168],"opposite":[21],"functions:":[22],"transcriptionally":[24],"active":[25],"TAp63":[26,35,54],"and":[27,41,55,90,103,114,121,136,172,197,218,223,247,256],"dominant-negative":[29,47],"DeltaNp63.":[30],"Similar":[31],"to":[32,66,87,97,118,140,210],"p53,":[33,53],"isoforms":[36,45],"induce":[37],"cell":[38,60],"cycle":[39],"arrest":[40,200],"apoptosis.":[42],"The":[43],"DeltaNp63":[44],"are":[46],"variants":[48],"opposing":[49],"activities":[51],"TAp73.":[56],"To":[57],"avoid":[58],"unnecessary":[59],"death":[61],"accompanied":[62],"by":[63,156,202],"proper":[64],"response":[65],"stress,":[67],"expression":[69],"family":[73],"members":[74],"must":[75],"be":[76,154],"tightly":[77],"regulated.":[78],"NAD(P)H":[79],"quinone":[80],"oxidoreductase":[81],"(NQO1)":[82],"has":[83],"recently":[84],"been":[85],"shown":[86],"interact":[88,119],"inhibit":[91],"degradation":[93],"p53.":[95],"Due":[96],"structural":[99],"similarities":[100],"between":[101,221],"p63,":[104],"we":[105,187],"were":[106],"interested":[107],"studying":[109],"ability":[111],"wild-type":[113],"polymorphic,":[115,163],"inactive":[116,164],"NQO1":[117,165,192,222,237],"stabilize":[122],"p63.":[123],"We":[124,149],"focused":[125],"on":[126],"TAp63gamma,":[127,169],"as":[128],"it":[129,137,171,174],"most":[132,225],"potent":[133,226],"activator":[135],"expected":[139],"have":[141,250],"role":[143,235],"tumor":[145,254],"suppression.":[146],"PRINCIPAL":[147],"FINDINGS:":[148],"show":[150],"that":[151,189],"TAp63gamma":[152,179,242],"can":[153],"degraded":[155],"20S":[158],"proteasomes.":[159],"Wild-type":[160],"but":[161],"not":[162],"physically":[166],"interacts":[167],"stabilizes":[170],"protects":[173],"this":[176,212],"degradation.":[177],"NQO1-mediated":[178],"stabilization":[180],"was":[181],"especially":[182,244],"prominent":[183],"under":[184],"stress.":[185],"Accordingly,":[186],"found":[188],"downregulation":[190],"inhibits":[193],"TAp63gamma-dependant":[194],"p21":[195],"upregulation":[196],"TAp63gamma-induced":[198],"growth":[199],"stimulated":[201],"doxorubicin.":[203],"CONCLUSIONS/SIGNIFICANCE:":[204],"Our":[205],"report":[206],"first":[209],"identify":[211],"new":[213],"mechanism":[214],"demonstrating":[215],"physical":[217],"functional":[219],"relationship":[220],"isoform,":[228],"TAp63gamma.":[229],"These":[230],"findings":[231],"appoint":[232],"direct":[234],"for":[236,253],"regulation":[240],"expression,":[243],"following":[245],"stress":[246],"may":[248],"therefore":[249],"clinical":[251],"implications":[252],"development":[255],"therapy.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
