{"id":"https://openalex.org/W2050396199","doi":"https://doi.org/10.1016/j.vaccine.2011.12.080","title":"Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressing Streptococcus pneumoniae populations","display_name":"Immunization with the RrgB321 fusion protein protects mice against both high and low pilus-expressing Streptococcus pneumoniae populations","publication_year":2011,"publication_date":"2011-12-31","ids":{"openalex":"https://openalex.org/W2050396199","doi":"https://doi.org/10.1016/j.vaccine.2011.12.080","mag":"2050396199","pmid":"https://pubmed.ncbi.nlm.nih.gov/22210141"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2011.12.080","doi":"https://doi.org/10.1016/j.vaccine.2011.12.080","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2011.12.080","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049068266","display_name":"Monica Moschioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139938","display_name":"Novartis (Italy)","ror":"https://ror.org/04rcxhq50","country_code":"IT","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210139938"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Moschioni","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100 Siena, Italy. monica.moschioni@novartis.com","Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100 Siena, Italy. monica.moschioni@novartis.com","institution_ids":["https://openalex.org/I4210139938"]},{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022557309","display_name":"Gabriella De Angelis","orcid":"https://orcid.org/0009-0008-4630-3230","observed_orcids":["https://orcid.org/0009-0008-4630-3230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriella De Angelis","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066812775","display_name":"Carole Harfouche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carole Harfouche","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040196700","display_name":"Esmeralda Bizzarri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esmeralda Bizzarri","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058564189","display_name":"Sara Filippini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Filippini","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045139210","display_name":"Elena Mori","orcid":"https://orcid.org/0000-0003-4697-9333","observed_orcids":["https://orcid.org/0000-0003-4697-9333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Mori","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010214694","display_name":"Giuseppe Mancuso","orcid":"https://orcid.org/0000-0001-5454-3228","observed_orcids":["https://orcid.org/0000-0001-5454-3228"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Mancuso","raw_affiliation_strings":["The Elie Metchnikoff Department, University of Messina, 98125 Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Elie Metchnikoff Department, University of Messina, 98125 Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088021211","display_name":"Francesco Doro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Doro","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066869748","display_name":"Mich\u00e8le A. Barocchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mich\u00e8le A. Barocchi","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029401545","display_name":"Paolo Ruggiero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Ruggiero","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030802364","display_name":"Vega Masignani","orcid":"https://orcid.org/0009-0004-2415-1521","observed_orcids":["https://orcid.org/0009-0004-2415-1521"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vega Masignani","raw_affiliation_strings":["Novartis Vaccines and Diagnostics, 53100, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Vaccines and Diagnostics, 53100, Siena, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030802364"],"corresponding_institution_ids":[],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":1.7389,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82374669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"7","first_page":"1349","last_page":"1356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.6499000191688538,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9390000104904175},{"id":"https://openalex.org/keywords/fusion-protein-vaccine","display_name":"fusion protein vaccine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pneumococcal-vaccine","display_name":"pneumococcal vaccine","score":0.6890000104904175},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.5590000152587891},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/antibody-mediated-protection","display_name":"antibody-mediated protection","score":0.4099999964237213},{"id":"https://openalex.org/keywords/protein-based-vaccines","display_name":"protein-based vaccines","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C174832134","wikidata":"https://www.wikidata.org/wiki/Q934786","display_name":"Pilus","level":4,"score":0.95860356092453},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8036787509918213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7065864205360413},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.6966250538825989},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47363653779029846},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.46298232674598694},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42950159311294556},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42448702454566956},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.422920286655426},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36533817648887634},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.1828218698501587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15288114547729492},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14939221739768982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1364324688911438},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.09764179587364197},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.06562581658363342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.055728256702423096},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009895","descriptor_name":"Opsonin Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D036781","descriptor_name":"Fimbriae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036781","descriptor_name":"Fimbriae Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.vaccine.2011.12.080","doi":"https://doi.org/10.1016/j.vaccine.2011.12.080","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2011.12.080","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:22210141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22210141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1664524954","https://openalex.org/W1993100997","https://openalex.org/W2001021771","https://openalex.org/W2009251244","https://openalex.org/W2020617498","https://openalex.org/W2033464521","https://openalex.org/W2041452716","https://openalex.org/W2049577822","https://openalex.org/W2076692857","https://openalex.org/W2081211831","https://openalex.org/W2081812685","https://openalex.org/W2083463655","https://openalex.org/W2089406976","https://openalex.org/W2094328879","https://openalex.org/W2097750123","https://openalex.org/W2098483219","https://openalex.org/W2102622434","https://openalex.org/W2114307734","https://openalex.org/W2135761651","https://openalex.org/W2137209708","https://openalex.org/W2149176649","https://openalex.org/W2155701029","https://openalex.org/W2159553344","https://openalex.org/W2159602930"],"related_works":["https://openalex.org/W1995376303","https://openalex.org/W2155701029","https://openalex.org/W1549678255","https://openalex.org/W607235381","https://openalex.org/W4311579392","https://openalex.org/W2109884161","https://openalex.org/W2137209708","https://openalex.org/W2041452716","https://openalex.org/W2156539070","https://openalex.org/W2129333922"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}