{"id":"https://openalex.org/W2050359010","doi":"https://doi.org/10.1016/j.micinf.2014.07.009","title":"Prophylactic effect of human lactoferrin against Streptococcus mutans bacteremia in lactoferrin knockout mice","display_name":"Prophylactic effect of human lactoferrin against Streptococcus mutans bacteremia in lactoferrin knockout mice","publication_year":2014,"publication_date":"2014-08-11","ids":{"openalex":"https://openalex.org/W2050359010","doi":"https://doi.org/10.1016/j.micinf.2014.07.009","mag":"2050359010","pmid":"https://pubmed.ncbi.nlm.nih.gov/25124544","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4252812"},"language":"en","primary_location":{"id":"doi:10.1016/j.micinf.2014.07.009","doi":"https://doi.org/10.1016/j.micinf.2014.07.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.micinf.2014.07.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1286457914000963/pdf","source":{"id":"https://openalex.org/S56361996","display_name":"Microbes and Infection","issn_l":"1286-4579","issn":["1286-4579","1769-714X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and Infection","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S1286457914000963/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088629420","display_name":"Senthil Kumar Velusamy","orcid":"https://orcid.org/0000-0002-5203-1357","observed_orcids":["https://orcid.org/0000-0002-5203-1357"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Senthil Kumar Velusamy","raw_affiliation_strings":["RUTGERS School of Dental Medicine, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RUTGERS School of Dental Medicine, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042440777","display_name":"Daniel H. Fine","orcid":"https://orcid.org/0000-0001-6242-6451","observed_orcids":["https://orcid.org/0000-0001-6242-6451"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel H. Fine","raw_affiliation_strings":["RUTGERS School of Dental Medicine, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RUTGERS School of Dental Medicine, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037221977","display_name":"Kabilan Velliyagounder","orcid":"https://orcid.org/0000-0001-6739-6511","observed_orcids":["https://orcid.org/0000-0001-6739-6511"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kabilan Velliyagounder","raw_affiliation_strings":["RUTGERS School of Dental Medicine, Newark, NJ, USA. Electronic address: velliyka@sdm.rutgers.edu","Rutgers School of Dental Medicine, Newark, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RUTGERS School of Dental Medicine, Newark, NJ, USA. Electronic address: velliyka@sdm.rutgers.edu","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Rutgers School of Dental Medicine, Newark, NJ, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037221977"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":1.2644,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.77404922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"9","first_page":"762","last_page":"767"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-lactoferrin","display_name":"human lactoferrin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/streptococcus-mutans","display_name":"Streptococcus mutans","score":1.0},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.8610000014305115},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.6729999780654907},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8920000195503235},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2779170986","wikidata":"https://www.wikidata.org/wiki/Q410246","display_name":"Lactoferrin","level":2,"score":0.9438316822052002},{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.8575718402862549},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.7065751552581787},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6831066012382507},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5351824164390564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4960244596004486},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4950241446495056},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4447753131389618},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.42991313338279724},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.21627327799797058},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1535063087940216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08893197774887085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07866173982620239},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.micinf.2014.07.009","doi":"https://doi.org/10.1016/j.micinf.2014.07.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.micinf.2014.07.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1286457914000963/pdf","source":{"id":"https://openalex.org/S56361996","display_name":"Microbes and Infection","issn_l":"1286-4579","issn":["1286-4579","1769-714X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and Infection","raw_type":"journal-article"},{"id":"pmid:25124544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25124544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and infection","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4252812","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4252812","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Microbes Infect","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.micinf.2014.07.009","doi":"https://doi.org/10.1016/j.micinf.2014.07.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.micinf.2014.07.009","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1286457914000963/pdf","source":{"id":"https://openalex.org/S56361996","display_name":"Microbes and Infection","issn_l":"1286-4579","issn":["1286-4579","1769-714X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and Infection","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1913719544","display_name":null,"funder_award_id":"#PC123\u201013","funder_id":"https://openalex.org/F4320306784","funder_display_name":"New Jersey Health Foundation"},{"id":"https://openalex.org/G3227283632","display_name":"Functions of Lactoferrin Polymorphisms in an Oral Infection","funder_award_id":"R21DE019548","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320306784","display_name":"New Jersey Health Foundation","ror":"https://ror.org/040may582"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2050359010.pdf","grobid_xml":"https://content.openalex.org/works/W2050359010.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W15985890","https://openalex.org/W49088916","https://openalex.org/W1829903344","https://openalex.org/W1836943961","https://openalex.org/W1863808583","https://openalex.org/W1920136005","https://openalex.org/W1969254170","https://openalex.org/W1979278926","https://openalex.org/W1983444348","https://openalex.org/W1984036306","https://openalex.org/W1986366861","https://openalex.org/W1989998756","https://openalex.org/W1996246154","https://openalex.org/W2000409833","https://openalex.org/W2006688720","https://openalex.org/W2012414025","https://openalex.org/W2017984301","https://openalex.org/W2026122295","https://openalex.org/W2030245139","https://openalex.org/W2035183539","https://openalex.org/W2037973217","https://openalex.org/W2042133266","https://openalex.org/W2054013470","https://openalex.org/W2071537619","https://openalex.org/W2083207134","https://openalex.org/W2086188997","https://openalex.org/W2096366985","https://openalex.org/W2099653041","https://openalex.org/W2101757691","https://openalex.org/W2102171009","https://openalex.org/W2111591737","https://openalex.org/W2115342230","https://openalex.org/W2115851261","https://openalex.org/W2118527351","https://openalex.org/W2122535584","https://openalex.org/W2123901230","https://openalex.org/W2129433279","https://openalex.org/W2129581959","https://openalex.org/W2141948326","https://openalex.org/W2150336290","https://openalex.org/W2151509257","https://openalex.org/W2155507633","https://openalex.org/W2164266688","https://openalex.org/W2415859941"],"related_works":["https://openalex.org/W2118527351","https://openalex.org/W2174513718","https://openalex.org/W4240912767","https://openalex.org/W2020261835","https://openalex.org/W2062519390","https://openalex.org/W2113195286","https://openalex.org/W2145329403","https://openalex.org/W2153179123","https://openalex.org/W2062255068","https://openalex.org/W4324054491"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}