{"id":"https://openalex.org/W2050355091","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb11298.x","title":"Thyroid Hormones and Derivatives Inhibit Flunitrazepam Binding","display_name":"Thyroid Hormones and Derivatives Inhibit Flunitrazepam Binding","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W2050355091","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb11298.x","mag":"2050355091","pmid":"https://pubmed.ncbi.nlm.nih.gov/6130126"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1983.tb11298.x","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb11298.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1983.tb11298.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011105258","display_name":"Andr\u00e1s Nagy","orcid":"https://orcid.org/0000-0003-4311-0413","observed_orcids":["https://orcid.org/0000-0003-4311-0413"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Nagy","raw_affiliation_strings":["Center for Neurochemistry, Rockland Research Institute, Ward's Island, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurochemistry, Rockland Research Institute, Ward's Island, New York, U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111641191","display_name":"\u00c1bel Lajtha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Lajtha","raw_affiliation_strings":["Center for Neurochemistry, Rockland Research Institute, Ward's Island, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurochemistry, Rockland Research Institute, Ward's Island, New York, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011105258"],"corresponding_institution_ids":[],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.2862,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.76665594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"40","issue":"2","first_page":"414","last_page":"417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.2678000032901764,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.9950000047683716},{"id":"https://openalex.org/keywords/flunitrazepam","display_name":"flunitrazepam","score":0.871999979019165},{"id":"https://openalex.org/keywords/benzodiazepine-receptor","display_name":"benzodiazepine receptor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/receptor-binding-inhibition","display_name":"receptor binding inhibition","score":0.8539999723434448},{"id":"https://openalex.org/keywords/d-thyroxine","display_name":"D-thyroxine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stereospecific-binding","display_name":"stereospecific binding","score":0.7549999952316284},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mixed-inhibition","display_name":"mixed-type inhibition","score":0.9409999847412109},{"id":"https://openalex.org/keywords/scatchard-analysis","display_name":"Scatchard analysis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/receptor-density","display_name":"receptor density","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2781442855","wikidata":"https://www.wikidata.org/wiki/Q62947","display_name":"Flunitrazepam","level":4,"score":0.8653073310852051},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7313693761825562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6397097110748291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6341626048088074},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.6180994510650635},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5142666697502136},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5097984671592712},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4831516146659851},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4760957956314087},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.36583539843559265},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2766953110694885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21426096558570862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16957664489746094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09507167339324951}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005445","descriptor_name":"Flunitrazepam","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1983.tb11298.x","doi":"https://doi.org/10.1111/j.1471-4159.1983.tb11298.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1983.tb11298.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:6130126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6130126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W69003580","https://openalex.org/W1965666249","https://openalex.org/W1966574405","https://openalex.org/W1994785056","https://openalex.org/W1998912161","https://openalex.org/W2017316214","https://openalex.org/W2021369559","https://openalex.org/W2041420063","https://openalex.org/W2051800632","https://openalex.org/W2064479755"],"related_works":["https://openalex.org/W2082364522","https://openalex.org/W2059666749","https://openalex.org/W2083256398","https://openalex.org/W1976554233","https://openalex.org/W2080707458","https://openalex.org/W2037952293","https://openalex.org/W2056745074","https://openalex.org/W2511561063","https://openalex.org/W2090151763","https://openalex.org/W2331748882"],"abstract_inverted_index":{"Thyroid":[0],"hormones":[1],"and":[2,12,90],"their":[3],"derivatives":[4],"were":[5],"found":[6],"to":[7,48],"inhibit":[8],"[3H]flunitrazepam":[9,87],"binding":[10,88],"stereospecifically":[11],"in":[13,58],"a":[14,97],"monophasic":[15],"manner.":[16],"Among":[17],"the":[18,23,51,55,59,72,86,91],"compounds":[19],"tested,":[20],"D-thyroxine":[21,100],"was":[22,35,69],"most":[24,73],"potent":[25,39,74],"inhibitor":[26],"(IC50":[27,40],"=":[28,41],"0.5":[29],"microM).":[30,43],"The":[31,44,65,80],"naturally":[32],"occurring":[33],"L-thyroxine":[34],"about":[36],"40-fold":[37],"less":[38],"20":[42],"structure-activity":[45],"relationships":[46],"seem":[47],"imply":[49],"that":[50],"thyronine":[52],"base":[53],"has":[54],"principal":[56],"role":[57],"inhibition":[60,68],"of":[61,67,85,99,105],"benzodiazepine":[62],"receptor":[63,92],"binding.":[64],"type":[66],"examined":[70],"with":[71],"inhibitor,":[75],"D-thyroxine,":[76],"by":[77],"Scatchard":[78],"analysis.":[79],"apparent":[81],"dissociation":[82],"constant":[83],"(KD)":[84],"increased":[89],"density":[93],"(Bmax)":[94],"decreased":[95],"as":[96],"function":[98],"concentration;":[101],"this":[102],"is":[103],"characteristic":[104],"mixed-type":[106],"inhibition.":[107]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
