{"id":"https://openalex.org/W2050189714","doi":"https://doi.org/10.1089/dna.2005.24.446","title":"Wnt Influence on Chondrocyte Differentiation and Cartilage Function","display_name":"Wnt Influence on Chondrocyte Differentiation and Cartilage Function","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2050189714","doi":"https://doi.org/10.1089/dna.2005.24.446","mag":"2050189714","pmid":"https://pubmed.ncbi.nlm.nih.gov/16008513"},"language":"en","primary_location":{"id":"doi:10.1089/dna.2005.24.446","doi":"https://doi.org/10.1089/dna.2005.24.446","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.2005.24.446","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003857860","display_name":"Karen E. Yates","orcid":"https://orcid.org/0000-0002-1844-8431","observed_orcids":["https://orcid.org/0000-0002-1844-8431"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen E. Yates","raw_affiliation_strings":["Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts","Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. kyates@partners.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. kyates@partners.org","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043090383","display_name":"Sonya Shortkroff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonya Shortkroff","raw_affiliation_strings":["Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031440910","display_name":"Richard G. Reish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Reish","raw_affiliation_strings":["Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8399,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.89223436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"7","first_page":"446","last_page":"457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":1.0},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.7400000095367432},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chondrocyte-maturation","display_name":"chondrocyte maturation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/limb-development","display_name":"limb development","score":0.9120000004768372},{"id":"https://openalex.org/keywords/joint-diseases","display_name":"joint diseases","score":0.5350000262260437},{"id":"https://openalex.org/keywords/avian-model","display_name":"avian model","score":0.5130000114440918},{"id":"https://openalex.org/keywords/mammalian-models","display_name":"mammalian models","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9285306930541992},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.8882324695587158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8344818353652954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6662832498550415},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6626994609832764},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5201978087425232},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4707415997982025},{"id":"https://openalex.org/C2779131293","wikidata":"https://www.wikidata.org/wiki/Q18048098","display_name":"WNT3A","level":4,"score":0.44034916162490845},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2708055078983307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23202213644981384},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12671977281570435}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/dna.2005.24.446","doi":"https://doi.org/10.1089/dna.2005.24.446","is_oa":false,"landing_page_url":"https://doi.org/10.1089/dna.2005.24.446","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},{"id":"pmid:16008513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16008513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/12","score":0.49000000953674316,"display_name":"Responsible consumption and production"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1872021268","display_name":"WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGE","funder_award_id":"R03AG023307","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7621637535","display_name":null,"funder_award_id":"AG23307","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320307122","display_name":"Aircast Foundation","ror":"https://ror.org/01722g748"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W24263518","https://openalex.org/W83699622","https://openalex.org/W195639557","https://openalex.org/W206711978","https://openalex.org/W1149635373","https://openalex.org/W1494249446","https://openalex.org/W1504655784","https://openalex.org/W1544751778","https://openalex.org/W1549691444","https://openalex.org/W1572014524","https://openalex.org/W1581446444","https://openalex.org/W1796612477","https://openalex.org/W1914909368","https://openalex.org/W1947391889","https://openalex.org/W1965603484","https://openalex.org/W1969206533","https://openalex.org/W1979120368","https://openalex.org/W1979415894","https://openalex.org/W1986754406","https://openalex.org/W1987588903","https://openalex.org/W1989918771","https://openalex.org/W1990985899","https://openalex.org/W1991758077","https://openalex.org/W1992152553","https://openalex.org/W1995617534","https://openalex.org/W1996898907","https://openalex.org/W2000291668","https://openalex.org/W2001372468","https://openalex.org/W2002073678","https://openalex.org/W2002169525","https://openalex.org/W2006595571","https://openalex.org/W2010118024","https://openalex.org/W2010390759","https://openalex.org/W2013064709","https://openalex.org/W2015974087","https://openalex.org/W2017668082","https://openalex.org/W2023146082","https://openalex.org/W2025563892","https://openalex.org/W2026080578","https://openalex.org/W2031592383","https://openalex.org/W2032337876","https://openalex.org/W2032600611","https://openalex.org/W2033625161","https://openalex.org/W2034816213","https://openalex.org/W2037834645","https://openalex.org/W2039285533","https://openalex.org/W2040723131","https://openalex.org/W2042045265","https://openalex.org/W2043248226","https://openalex.org/W2046386430","https://openalex.org/W2048675800","https://openalex.org/W2050486464","https://openalex.org/W2051249644","https://openalex.org/W2051788298","https://openalex.org/W2052060006","https://openalex.org/W2052822538","https://openalex.org/W2056301653","https://openalex.org/W2058529389","https://openalex.org/W2058721833","https://openalex.org/W2059532513","https://openalex.org/W2062340542","https://openalex.org/W2064147082","https://openalex.org/W2066378061","https://openalex.org/W2067056588","https://openalex.org/W2067217913","https://openalex.org/W2071291390","https://openalex.org/W2073548934","https://openalex.org/W2073676252","https://openalex.org/W2079819294","https://openalex.org/W2080122844","https://openalex.org/W2081577257","https://openalex.org/W2082978552","https://openalex.org/W2084429892","https://openalex.org/W2084771679","https://openalex.org/W2085658088","https://openalex.org/W2086365989","https://openalex.org/W2086407300","https://openalex.org/W2086694435","https://openalex.org/W2092429962","https://openalex.org/W2098067206","https://openalex.org/W2101981774","https://openalex.org/W2104204293","https://openalex.org/W2105565758","https://openalex.org/W2106261878","https://openalex.org/W2112160006","https://openalex.org/W2114094342","https://openalex.org/W2115296157","https://openalex.org/W2116610925","https://openalex.org/W2119413986","https://openalex.org/W2120840387","https://openalex.org/W2123039189","https://openalex.org/W2124385965","https://openalex.org/W2125008623","https://openalex.org/W2125497089","https://openalex.org/W2125635238","https://openalex.org/W2125734437","https://openalex.org/W2125964134","https://openalex.org/W2132884161","https://openalex.org/W2133831512","https://openalex.org/W2138094668","https://openalex.org/W2140034535","https://openalex.org/W2143758659","https://openalex.org/W2148294117","https://openalex.org/W2149790590","https://openalex.org/W2153042507","https://openalex.org/W2154041910","https://openalex.org/W2155348369","https://openalex.org/W2156726032","https://openalex.org/W2159263213","https://openalex.org/W2159315880","https://openalex.org/W2162821604","https://openalex.org/W2165061154","https://openalex.org/W2166428507","https://openalex.org/W2167125699","https://openalex.org/W2171126701","https://openalex.org/W2274730818","https://openalex.org/W2435525443","https://openalex.org/W4237338190","https://openalex.org/W4292542165","https://openalex.org/W4320996308"],"related_works":["https://openalex.org/W2021210134","https://openalex.org/W1672213021","https://openalex.org/W1909322285","https://openalex.org/W1947391889","https://openalex.org/W3010847014","https://openalex.org/W2185064384","https://openalex.org/W4302392494","https://openalex.org/W1986496039","https://openalex.org/W2155664056","https://openalex.org/W185530423"],"abstract_inverted_index":{"The":[0],"Wnt":[1,21,43,64,76],"signaling":[2,22,44,65,100],"network":[3,77],"regulates":[4],"chondrocyte":[5,25,96],"differentiation,":[6],"proliferation,":[7],"and":[8,30,35,106],"maturation":[9],"during":[10,23],"embryonic":[11],"limb":[12],"development.":[13],"In":[14,56],"this":[15],"review,":[16],"we":[17,58],"summarize":[18],"studies":[19],"of":[20,95],"the":[24,75],"life":[26],"cycle":[27],"in":[28,68,81,87],"avian":[29],"mammalian":[31],"systems,":[32],"both":[33],"before":[34],"after":[36],"birth.":[37],"Recent":[38],"reports":[39],"that":[40,62,74],"implicate":[41],"abnormal":[42],"as":[45,83],"a":[46],"contributing":[47],"factor":[48],"to":[49,103,109],"pathogenic":[50],"joint":[51],"conditions":[52],"are":[53],"also":[54],"discussed.":[55],"addition,":[57],"show":[59],"new":[60],"data":[61],"suggests":[63],"is":[66,91,101],"active":[67],"adult":[69],"cartilage.":[70],"Overall,":[71],"it":[72,90],"appears":[73],"has":[78,84],"dual":[79],"roles":[80],"cartilage,":[82],"been":[85],"described":[86],"other":[88],"tissues:":[89],"an":[92],"important":[93],"regulator":[94],"development,":[97],"but":[98],"deregulated":[99],"detrimental":[102],"mature":[104],"tissues":[105],"may":[107],"lead":[108],"disease.":[110]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
