{"id":"https://openalex.org/W2050176313","doi":"https://doi.org/10.1080/10715760500177880","title":"Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: Mechanistic aspects and antioxidant activity","display_name":"Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: Mechanistic aspects and antioxidant activity","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2050176313","doi":"https://doi.org/10.1080/10715760500177880","mag":"2050176313","pmid":"https://pubmed.ncbi.nlm.nih.gov/16298742"},"language":"en","primary_location":{"id":"doi:10.1080/10715760500177880","doi":"https://doi.org/10.1080/10715760500177880","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10715760500177880","pdf_url":null,"source":{"id":"https://openalex.org/S23349031","display_name":"Free Radical Research","issn_l":"1029-2470","issn":["1029-2470","1071-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080084745","display_name":"Ravi Kumar Joshi","orcid":"https://orcid.org/0000-0002-7617-5451","observed_orcids":["https://orcid.org/0000-0002-7617-5451"]},"institutions":[{"id":"https://openalex.org/I1329621470","display_name":"Bhabha Atomic Research Centre","ror":"https://ror.org/05w6wfp17","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1329621470","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ravi Joshi","raw_affiliation_strings":["Radiation Chemistry & Chemical Dynamics Division, Chemistry Group, Bhabha Atomic Research Center, Mumbai, India. rjudrin@yahoo.com","Bhabha Atomic Research Center, Radiation Chemistry & Chemical Dynamics Division, Chemistry Group, Mumbai, 400 085, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Chemistry & Chemical Dynamics Division, Chemistry Group, Bhabha Atomic Research Center, Mumbai, India. rjudrin@yahoo.com","institution_ids":["https://openalex.org/I1329621470"]},{"raw_affiliation_string":"Bhabha Atomic Research Center, Radiation Chemistry & Chemical Dynamics Division, Chemistry Group, Mumbai, 400 085, India","institution_ids":["https://openalex.org/I1329621470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059429113","display_name":"Sudheer Kumar","orcid":"https://orcid.org/0000-0001-9483-6180","observed_orcids":["https://orcid.org/0000-0001-9483-6180"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudheer Kumar","raw_affiliation_strings":["College of Pharmaceutical Sciences, Manipal, 576119, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Manipal, 576119, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036439698","display_name":"Mazhuvancherry Kesavan Unnikrishnan","orcid":"https://orcid.org/0000-0002-9654-2028","observed_orcids":["https://orcid.org/0000-0002-9654-2028"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. Unnikrishnan","raw_affiliation_strings":["College of Pharmaceutical Sciences, Manipal, 576119, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Manipal, 576119, India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062762737","display_name":"Tulsi Mukherjee","orcid":"https://orcid.org/0000-0003-1167-3748","observed_orcids":["https://orcid.org/0000-0003-1167-3748"]},"institutions":[{"id":"https://openalex.org/I1329621470","display_name":"Bhabha Atomic Research Centre","ror":"https://ror.org/05w6wfp17","country_code":"IN","type":"facility","lineage":["https://openalex.org/I1329621470","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"T. Mukherjee","raw_affiliation_strings":["Bhabha Atomic Research Center, Radiation Chemistry & Chemical Dynamics Division, Chemistry Group, Mumbai, 400 085, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bhabha Atomic Research Center, Radiation Chemistry & Chemical Dynamics Division, Chemistry Group, Mumbai, 400 085, India","institution_ids":["https://openalex.org/I1329621470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080084745"],"corresponding_institution_ids":["https://openalex.org/I1329621470"],"apc_list":null,"apc_paid":null,"fwci":2.0966,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.85275488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"39","issue":"11","first_page":"1163","last_page":"1172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":1.0},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":1.0},{"id":"https://openalex.org/keywords/sulfapyridine","display_name":"sulfapyridine","score":1.0},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/radical-reaction-mechanism","display_name":"radical reaction mechanism","score":0.6349999904632568},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lipid-peroxyl-radicals","display_name":"lipid peroxyl radicals","score":0.9200000166893005},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7860000133514404},{"id":"https://openalex.org/keywords/radical-anions","display_name":"radical anions","score":0.7590000033378601},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7609999775886536},{"id":"https://openalex.org/keywords/anti-inflammatory-mechanism","display_name":"anti-inflammatory mechanism","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9281539916992188},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.9188371300697327},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.6199623346328735},{"id":"https://openalex.org/C2777031107","wikidata":"https://www.wikidata.org/wiki/Q3976827","display_name":"Sulfapyridine","level":2,"score":0.61503005027771},{"id":"https://openalex.org/C77176794","wikidata":"https://www.wikidata.org/wiki/Q187689","display_name":"Oxidizing agent","level":2,"score":0.5921956896781921},{"id":"https://openalex.org/C66887884","wikidata":"https://www.wikidata.org/wiki/Q2126498","display_name":"Radiolysis","level":3,"score":0.5637354254722595},{"id":"https://openalex.org/C2779383735","wikidata":"https://www.wikidata.org/wiki/Q420035","display_name":"Sulfasalazine","level":4,"score":0.5186392664909363},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.51103675365448},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.48163264989852905},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4721405804157257},{"id":"https://openalex.org/C29773484","wikidata":"https://www.wikidata.org/wiki/Q7280480","display_name":"Radical disproportionation","level":4,"score":0.44891366362571716},{"id":"https://openalex.org/C2777807096","wikidata":"https://www.wikidata.org/wiki/Q1285257","display_name":"Scavenging","level":3,"score":0.4432031512260437},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3108639717102051},{"id":"https://openalex.org/C17365422","wikidata":"https://www.wikidata.org/wiki/Q664231","display_name":"Disproportionation","level":3,"score":0.15950652956962585},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07668092846870422},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07652395963668823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000636","descriptor_name":"Aminosalicylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004583","descriptor_name":"Electrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011675","descriptor_name":"Pulse Radiolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013427","descriptor_name":"Sulfapyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013427","descriptor_name":"Sulfapyridine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/10715760500177880","doi":"https://doi.org/10.1080/10715760500177880","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10715760500177880","pdf_url":null,"source":{"id":"https://openalex.org/S23349031","display_name":"Free Radical Research","issn_l":"1029-2470","issn":["1029-2470","1071-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research","raw_type":"journal-article"},{"id":"pmid:16298742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16298742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W57725725","https://openalex.org/W194144406","https://openalex.org/W1530016393","https://openalex.org/W1540721474","https://openalex.org/W1587708141","https://openalex.org/W1800451545","https://openalex.org/W1926950498","https://openalex.org/W1963820921","https://openalex.org/W1965609339","https://openalex.org/W1979425960","https://openalex.org/W1987695378","https://openalex.org/W1997252947","https://openalex.org/W2001078312","https://openalex.org/W2002787150","https://openalex.org/W2018535431","https://openalex.org/W2022833615","https://openalex.org/W2024513902","https://openalex.org/W2038575244","https://openalex.org/W2038896155","https://openalex.org/W2045258118","https://openalex.org/W2056164032","https://openalex.org/W2059769997","https://openalex.org/W2063089637","https://openalex.org/W2068119928","https://openalex.org/W2077662223","https://openalex.org/W2079771797","https://openalex.org/W2082216829","https://openalex.org/W2086568865","https://openalex.org/W2092646788","https://openalex.org/W2130446979","https://openalex.org/W2140095307","https://openalex.org/W2165679967","https://openalex.org/W2218682741","https://openalex.org/W2253251593","https://openalex.org/W2329981499","https://openalex.org/W2340564470","https://openalex.org/W2414128339","https://openalex.org/W2414645373","https://openalex.org/W2475388429","https://openalex.org/W3185722968","https://openalex.org/W4214658765"],"related_works":["https://openalex.org/W2037311138","https://openalex.org/W7097289568","https://openalex.org/W1602033104","https://openalex.org/W2089378927","https://openalex.org/W2063954301","https://openalex.org/W2414128339","https://openalex.org/W1540721474","https://openalex.org/W1979425960","https://openalex.org/W139140419","https://openalex.org/W1587708141"],"abstract_inverted_index":{"Reactions":[0],"of":[1,38,62,92,113,124,130,136,150,157,160],"sulfasalazine":[2],"(SAZ)":[3],"and":[4,10,16,65,80,95,102],"its":[5,39],"metabolites,":[6],"5-aminosalicylic":[7],"acid":[8],"(5-ASA)":[9],"sulfapyridine":[11],"(SP),":[12],"with":[13,52],"various":[14,93],"oxidizing":[15,131],"reducing":[17],"free":[18,42,63,97,132,146],"radicals":[19,43,64,98,112,133],"(hydroxyl,":[20],"haloperoxyl,":[21],"one-electron":[22],"oxidizing,":[23],"lipid":[24],"peroxyl,":[25],"glutathiyl,":[26],"superoxide,":[27],"tryptophanyl,":[28],"etc.)":[29],"have":[30,77,85],"been":[31,56,78,86,107,117],"studied":[32],"to":[33,66,90,109,119],"understand":[34],"the":[35,121,128],"mechanistic":[36],"aspects":[37],"action":[40,159],"against":[41,162],"produced":[44,73,138],"during":[45],"inflammation.":[46],"Nanosecond":[47],"pulse":[48],"radiolysis":[49],"technique":[50],"coupled":[51],"transient":[53],"spectrophotometry":[54],"has":[55,105,116],"used":[57],"for":[58],"in":[59,74,127],"situ":[60],"generation":[61],"follow":[67],"their":[68],"reaction":[69],"pathways.":[70],"The":[71,142],"transients":[72],"these":[75],"reactions":[76],"assigned":[79],"radical":[81,140,147],"scavenging":[82,91,129,148],"rate":[83],"constants":[84],"measured.":[87],"In":[88],"addition":[89],"primary":[94],"secondary":[96],"by":[99],"SAZ,":[100],"5-ASA":[101,104,115,151],"SP,":[103],"also":[106],"observed":[108],"efficiently":[110],"scavenge":[111],"biomolecules.":[114],"found":[118],"be":[120,153],"active":[122],"moiety":[123],"SAZ":[125,137,161],"involved":[126],"whereas":[134],"reduction":[135],"molecular":[139],"anion.":[141],"study":[143],"suggests":[144],"that":[145],"activity":[149],"may":[152],"a":[154],"major":[155],"path":[156],"pharmacological":[158],"inflammatory":[163],"bowel":[164],"diseases":[165],"(IBD).":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
