{"id":"https://openalex.org/W2050175422","doi":"https://doi.org/10.1016/j.cell.2004.09.037","title":"Biological Control through Regulated Transcriptional Coactivators","display_name":"Biological Control through Regulated Transcriptional Coactivators","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2050175422","doi":"https://doi.org/10.1016/j.cell.2004.09.037","mag":"2050175422","pmid":"https://pubmed.ncbi.nlm.nih.gov/15479634"},"language":"en","primary_location":{"id":"doi:10.1016/j.cell.2004.09.037","doi":"https://doi.org/10.1016/j.cell.2004.09.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2004.09.037","pdf_url":"http://www.cell.com/article/S0092867404009456/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867404009456/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022918796","display_name":"Bruce M. Spiegelman","orcid":"https://orcid.org/0000-0002-7658-4802","observed_orcids":["https://orcid.org/0000-0002-7658-4802"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce M. Spiegelman","raw_affiliation_strings":["Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA. bruce_speigelman@dfci.harvard.edu","Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA. bruce_speigelman@dfci.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112761243","display_name":"Reinhart Heinrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhart Heinrich","raw_affiliation_strings":["Institute of Biology, Section of Theoretical Biophysics, Humboldt University, 10115 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology, Section of Theoretical Biophysics, Humboldt University, 10115 Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022918796"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":2.6285,"has_fulltext":false,"cited_by_count":383,"citation_normalized_percentile":{"value":0.92669469,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"119","issue":"2","first_page":"157","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.7580000162124634},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7440000176429749},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.7490000128746033},{"id":"https://openalex.org/keywords/smooth-muscle-cell-differentiation","display_name":"smooth muscle differentiation","score":1.0},{"id":"https://openalex.org/keywords/hepatic-gluconeogenesis","display_name":"hepatic gluconeogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kinetic-control","display_name":"kinetic control","score":0.4740000069141388},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8433603048324585},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7436660528182983},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.6737717390060425},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.643104076385498},{"id":"https://openalex.org/C137365298","wikidata":"https://www.wikidata.org/wiki/Q7833928","display_name":"Transcription coregulator","level":5,"score":0.6128299832344055},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48441842198371887},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4576278328895569},{"id":"https://openalex.org/C144825837","wikidata":"https://www.wikidata.org/wiki/Q2316030","display_name":"General transcription factor","level":5,"score":0.4516139328479767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38219571113586426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33001452684402466},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3217390179634094},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31964215636253357},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3132443428039551},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.19567826390266418},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cell.2004.09.037","doi":"https://doi.org/10.1016/j.cell.2004.09.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2004.09.037","pdf_url":"http://www.cell.com/article/S0092867404009456/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:15479634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15479634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cell.2004.09.037","doi":"https://doi.org/10.1016/j.cell.2004.09.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2004.09.037","pdf_url":"http://www.cell.com/article/S0092867404009456/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G150446594","display_name":null,"funder_award_id":"DK54477","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8907317321","display_name":"PGC1 proteins, meteorin-like and energy homeostasis","funder_award_id":"R01DK061562","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2050175422.pdf"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W278636550","https://openalex.org/W1484198052","https://openalex.org/W1493268813","https://openalex.org/W1523158326","https://openalex.org/W1543833632","https://openalex.org/W1561767438","https://openalex.org/W1583767403","https://openalex.org/W1603786143","https://openalex.org/W1605945811","https://openalex.org/W1613446635","https://openalex.org/W1642162696","https://openalex.org/W1646199134","https://openalex.org/W1665938856","https://openalex.org/W1833742808","https://openalex.org/W1966458894","https://openalex.org/W1967364632","https://openalex.org/W1970569586","https://openalex.org/W1976998737","https://openalex.org/W1981022538","https://openalex.org/W1982128166","https://openalex.org/W1982824348","https://openalex.org/W1986167698","https://openalex.org/W1989341414","https://openalex.org/W1990529844","https://openalex.org/W1995004764","https://openalex.org/W1995637965","https://openalex.org/W1997868107","https://openalex.org/W2000936115","https://openalex.org/W2008632158","https://openalex.org/W2009265893","https://openalex.org/W2012155675","https://openalex.org/W2014442773","https://openalex.org/W2018658982","https://openalex.org/W2019222060","https://openalex.org/W2021768020","https://openalex.org/W2032266813","https://openalex.org/W2033386138","https://openalex.org/W2037395908","https://openalex.org/W2044782567","https://openalex.org/W2046566365","https://openalex.org/W2049869441","https://openalex.org/W2053765200","https://openalex.org/W2054338068","https://openalex.org/W2056806829","https://openalex.org/W2056978878","https://openalex.org/W2057307695","https://openalex.org/W2060128629","https://openalex.org/W2061052500","https://openalex.org/W2063304153","https://openalex.org/W2064323791","https://openalex.org/W2064956340","https://openalex.org/W2066730341","https://openalex.org/W2071551293","https://openalex.org/W2071631797","https://openalex.org/W2072972072","https://openalex.org/W2073133361","https://openalex.org/W2079833285","https://openalex.org/W2081703555","https://openalex.org/W2083347345","https://openalex.org/W2087236819","https://openalex.org/W2087393295","https://openalex.org/W2088086126","https://openalex.org/W2091673304","https://openalex.org/W2095060581","https://openalex.org/W2096628719","https://openalex.org/W2103680698","https://openalex.org/W2103988401","https://openalex.org/W2104147399","https://openalex.org/W2104200252","https://openalex.org/W2110259586","https://openalex.org/W2110743056","https://openalex.org/W2113019448","https://openalex.org/W2116545115","https://openalex.org/W2122709844","https://openalex.org/W2124612536","https://openalex.org/W2129289858","https://openalex.org/W2130527936","https://openalex.org/W2131492087","https://openalex.org/W2137058559","https://openalex.org/W2141880379","https://openalex.org/W2145944075","https://openalex.org/W2146727351","https://openalex.org/W2150581509","https://openalex.org/W2151463503","https://openalex.org/W2151849975","https://openalex.org/W2160290612","https://openalex.org/W2160769801","https://openalex.org/W2601704071","https://openalex.org/W6637037135","https://openalex.org/W6678459490","https://openalex.org/W6931824552"],"related_works":["https://openalex.org/W4388617035","https://openalex.org/W2118000816","https://openalex.org/W2101599992","https://openalex.org/W1503498484","https://openalex.org/W1988277530","https://openalex.org/W1984197098","https://openalex.org/W4380899770","https://openalex.org/W1993632339","https://openalex.org/W2036967394","https://openalex.org/W2005705056"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}