{"id":"https://openalex.org/W2050175281","doi":"https://doi.org/10.1002/glia.20324","title":"Sphingosine\u20101\u2010phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi\u2010protein\u2010coupled receptors","display_name":"Sphingosine\u20101\u2010phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi\u2010protein\u2010coupled receptors","publication_year":2006,"publication_date":"2006-02-07","ids":{"openalex":"https://openalex.org/W2050175281","doi":"https://doi.org/10.1002/glia.20324","mag":"2050175281","pmid":"https://pubmed.ncbi.nlm.nih.gov/16470810"},"language":"en","primary_location":{"id":"doi:10.1002/glia.20324","doi":"https://doi.org/10.1002/glia.20324","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.20324","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045370280","display_name":"Rosaria Bassi","orcid":"https://orcid.org/0000-0001-7409-4730","observed_orcids":["https://orcid.org/0000-0001-7409-4730"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosaria Bassi","raw_affiliation_strings":["Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034563112","display_name":"Viviana Anelli","orcid":"https://orcid.org/0000-0003-1964-3252","observed_orcids":["https://orcid.org/0000-0003-1964-3252"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Viviana Anelli","raw_affiliation_strings":["Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031903259","display_name":"Paola Giussani","orcid":"https://orcid.org/0000-0002-7793-1757","observed_orcids":["https://orcid.org/0000-0002-7793-1757"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Giussani","raw_affiliation_strings":["Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026977045","display_name":"Guido Tettamanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Tettamanti","raw_affiliation_strings":["Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016947354","display_name":"Paola Viani","orcid":"https://orcid.org/0000-0002-5728-6631","observed_orcids":["https://orcid.org/0000-0002-5728-6631"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Viani","raw_affiliation_strings":["Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010798226","display_name":"Laura Riboni","orcid":"https://orcid.org/0000-0002-4149-8226","observed_orcids":["https://orcid.org/0000-0002-4149-8226"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Laura Riboni","raw_affiliation_strings":["Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy","Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, via Fratelli Cervi 93, LITA\u2010Segrate, 20090 Segrate, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA-Segrate, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, via Fratelli Cervi 93, LITA\u2010Segrate, 20090 Segrate, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010798226"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":3.2562,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.93035699,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"6","first_page":"621","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":1.0},{"id":"https://openalex.org/keywords/cerebellar-astrocytes","display_name":"cerebellar astrocytes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9419999718666077},{"id":"https://openalex.org/keywords/astrocyte-proliferation","display_name":"astrocyte proliferation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/s1p-receptors","display_name":"S1P receptors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gi-protein-coupled-receptors","display_name":"Gi protein-coupled receptors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase","display_name":"extracellular signal-regulated kinase","score":0.796999990940094},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.6740000247955322},{"id":"https://openalex.org/keywords/autocrine-paracrine-signaling","display_name":"autocrine and paracrine signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/reactive-gliosis","display_name":"reactive gliosis","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2777700496","wikidata":"https://www.wikidata.org/wiki/Q7576797","display_name":"Sphingosine kinase","level":5,"score":0.7670919895172119},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.7350220680236816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7215232849121094},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7062379121780396},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.6489742398262024},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.634781002998352},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5424384474754333},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.5058403015136719},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.49344220757484436},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4533608853816986},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.41291525959968567},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3294937014579773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3252120018005371},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.25118517875671387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24604862928390503},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.06641685962677002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000099157","descriptor_name":"Sphingosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019206","descriptor_name":"GTP-Binding Protein alpha Subunits, Gi-Go","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019206","descriptor_name":"GTP-Binding Protein alpha Subunits, Gi-Go","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/glia.20324","doi":"https://doi.org/10.1002/glia.20324","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.20324","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:16470810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16470810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W83830075","https://openalex.org/W85524583","https://openalex.org/W1492769277","https://openalex.org/W1595397037","https://openalex.org/W1598200894","https://openalex.org/W1775749144","https://openalex.org/W1970044546","https://openalex.org/W1975993297","https://openalex.org/W1977644244","https://openalex.org/W1978956991","https://openalex.org/W1979555700","https://openalex.org/W1981429512","https://openalex.org/W1982533264","https://openalex.org/W1987121211","https://openalex.org/W1988839950","https://openalex.org/W1989420673","https://openalex.org/W1993560633","https://openalex.org/W1994785222","https://openalex.org/W1995091027","https://openalex.org/W2006207066","https://openalex.org/W2011918841","https://openalex.org/W2015995193","https://openalex.org/W2017277051","https://openalex.org/W2018511244","https://openalex.org/W2018729128","https://openalex.org/W2022770236","https://openalex.org/W2023166258","https://openalex.org/W2024071435","https://openalex.org/W2026948475","https://openalex.org/W2027429767","https://openalex.org/W2038101220","https://openalex.org/W2046390179","https://openalex.org/W2047157003","https://openalex.org/W2047453411","https://openalex.org/W2050473420","https://openalex.org/W2052745477","https://openalex.org/W2052890510","https://openalex.org/W2059994807","https://openalex.org/W2060640118","https://openalex.org/W2060731825","https://openalex.org/W2075926091","https://openalex.org/W2085488090","https://openalex.org/W2086674389","https://openalex.org/W2099814992","https://openalex.org/W2101096700","https://openalex.org/W2102312857","https://openalex.org/W2105218146","https://openalex.org/W2106970117","https://openalex.org/W2108825594","https://openalex.org/W2123274906","https://openalex.org/W2124440700","https://openalex.org/W2127330795","https://openalex.org/W2127338217","https://openalex.org/W2142035879","https://openalex.org/W2144702000","https://openalex.org/W2152934805","https://openalex.org/W2168976923","https://openalex.org/W2171264454","https://openalex.org/W2402835828","https://openalex.org/W4233150381","https://openalex.org/W4300619959"],"related_works":["https://openalex.org/W4254170080","https://openalex.org/W4390836026","https://openalex.org/W2047453411","https://openalex.org/W2102312857","https://openalex.org/W2171264454","https://openalex.org/W1975993297","https://openalex.org/W2098737774","https://openalex.org/W2742412339","https://openalex.org/W1598200894","https://openalex.org/W1981950875"],"abstract_inverted_index":{"The":[0,50,201,227],"mitogenic":[1,146],"role":[2,238],"of":[3,21,32,103,109,129,184,208],"sphingosine-1-phosphate":[4],"(S1P)":[5],"and":[6,95,165,187,232,249],"its":[7],"involvement":[8],"in":[9,18,28,46,65,72,170,239],"basic":[10],"fibroblast":[11],"growth":[12,61],"factor":[13],"(bFGF)-induced":[14],"proliferation":[15,186],"were":[16],"examined":[17],"primary":[19],"cultures":[20],"cerebellar":[22,149,171],"astrocytes.":[23],"Exposure":[24],"to":[25,39,84,205,223,225],"bFGF":[26,36,190,214],"resulted":[27],"a":[29,69,81,145,181],"rapid":[30],"increase":[31,71],"extracellular":[33,48,110],"S1P":[34,55,63,91,105,121,130,143,157,202,231],"formation,":[35],"inducing":[37],"astrocytes":[38,67,150,172,222],"release":[40,56],"S1P,":[41,87],"but":[42,131],"not":[43,133],"sphingosine":[44],"kinase,":[45],"the":[47,90,120,126,140],"milieu.":[49],"SK":[51],"inhibitor":[52,123],"N,N-dimethylsphingosine":[53],"inhibited":[54,96,115,198],"as":[57,59,244],"well":[58],"bFGF-induced":[60],"stimulation.":[62],"application":[64],"quiescent":[66],"caused":[68],"dose-dependent":[70],"DNA":[73,135],"synthesis.":[74,136],"This":[75],"gliotrophic":[76],"effect":[77,147],"was":[78,114],"induced":[79,107,125],"by":[80,89,97,117,189,213],"brief":[82],"exposure":[83],"low":[85],"nanomolar":[86],"mimicked":[88],"receptor":[92],"agonist":[93],"dihydro-S1P,":[94],"pertussis":[98],"toxin":[99],"(PTX),":[100],"an":[101,209,236],"inactivator":[102],"G(i)/G(o)-proteins.":[104],"also":[106],"activation":[108],"signal-regulated":[111],"kinase":[112],"that":[113,142,230],"again":[116],"PTX.":[118],"Moreover,":[119],"lyase":[122],"4-deoxypyridoxine":[124],"cellular":[127],"accumulation":[128],"did":[132],"affect":[134],"These":[137],"results":[138,228],"support":[139],"view":[141],"exerted":[144],"on":[148],"extracellularly,":[151],"most":[152],"likely":[153],"through":[154],"cell":[155],"surface":[156],"receptors.":[158],"In":[159],"agreement,":[160],"mRNAs":[161],"for":[162,221],"S1P1,":[163],"S1P2,":[164],"S1P3":[166],"receptors":[167],"are":[168],"expressed":[169],"(Anelli":[173],"et":[174,192],"al.,":[175,193],"2005.":[176],"J":[177],"Neurochem":[178],"92:1204-1215).":[179],"Ceramide,":[180],"negative":[182],"regulator":[183],"astrocyte":[185],"down-regulated":[188],"(Riboni":[191],"2002.":[194],"Cerebellum":[195],"1:129-135),":[196],"efficiently":[197],"S1P-induced":[199],"proliferation.":[200],"action":[203],"appears":[204],"be":[206],"part":[207],"autocrine/paracrine":[210],"cascade":[211],"stimulated":[212],"and,":[215],"together":[216],"with":[217],"ceramide":[218],"down-regulation,":[219],"essential":[220],"respond":[224],"bFGF.":[226],"suggest":[229],"bFGF/S1P":[233],"may":[234],"play":[235],"important":[237],"physiopathological":[240],"glial":[241],"proliferation,":[242],"such":[243],"brain":[245,250],"development,":[246],"reactive":[247],"gliosis":[248],"tumor":[251],"formation.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}