{"id":"https://openalex.org/W2050156090","doi":"https://doi.org/10.1111/j.1525-1594.1996.tb00666.x","title":"In Vitro Studies on a New Method for Islet Microencapsulation Using a Thermoreversible Gelation Polymer, N\u2010Isopropylacrylamide\u2010Based Copolymer","display_name":"In Vitro Studies on a New Method for Islet Microencapsulation Using a Thermoreversible Gelation Polymer, N\u2010Isopropylacrylamide\u2010Based Copolymer","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2050156090","doi":"https://doi.org/10.1111/j.1525-1594.1996.tb00666.x","mag":"2050156090","pmid":"https://pubmed.ncbi.nlm.nih.gov/8908335"},"language":"en","primary_location":{"id":"doi:10.1111/j.1525-1594.1996.tb00666.x","doi":"https://doi.org/10.1111/j.1525-1594.1996.tb00666.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-1594.1996.tb00666.x","pdf_url":null,"source":{"id":"https://openalex.org/S40391745","display_name":"Artificial Organs","issn_l":"0160-564X","issn":["0160-564X","1525-1594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Organs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072292164","display_name":"Shinichi Shimizu","orcid":"https://orcid.org/0000-0003-3143-0479","observed_orcids":["https://orcid.org/0000-0003-3143-0479"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinichi Shimizu","raw_affiliation_strings":["First Department of Surgery, St. Marianna University School of Medicine, Kanagawa, Japan","First Department of Surgery, St. Marianna University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, St. Marianna University School of Medicine, Kanagawa, Japan","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"First Department of Surgery, St. Marianna University School of Medicine","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Manabu Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manabu Yamazaki","raw_affiliation_strings":["Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111645377","display_name":"Sunao Kubota","orcid":"https://orcid.org/0009-0004-8746-3901","observed_orcids":["https://orcid.org/0009-0004-8746-3901"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sunao Kubota","raw_affiliation_strings":["First Department of Surgery, St. Marianna University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, St. Marianna University School of Medicine","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111571171","display_name":"Takao Ozasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Ozasa","raw_affiliation_strings":["First Department of Surgery, St. Marianna University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, St. Marianna University School of Medicine","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113609504","display_name":"Hitonobu Moriya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitonobu Moriya","raw_affiliation_strings":["First Department of Surgery, St. Marianna University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, St. Marianna University School of Medicine","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040921466","display_name":"Ken\u2010yu Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenyu Kobayashi","raw_affiliation_strings":["Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masato Mikami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masato Mikami","raw_affiliation_strings":["Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109355896","display_name":"Yuichi Mori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuichi Mori","raw_affiliation_strings":["Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Research Center, W. R. Grace & Co.-Conn, Kanagawa, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103468718","display_name":"Susumu Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Yamaguchi","raw_affiliation_strings":["First Department of Surgery, St. Marianna University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, St. Marianna University School of Medicine","institution_ids":["https://openalex.org/I163917720"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072292164"],"corresponding_institution_ids":["https://openalex.org/I163917720"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":1.2082,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.75280179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"20","issue":"11","first_page":"1232","last_page":"1237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-microencapsulation","display_name":"islet microencapsulation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/n-isopropylacrylamide-copolymers","display_name":"N-isopropylacrylamide copolymers","score":0.9739999771118164},{"id":"https://openalex.org/keywords/thermoreversible-gelation","display_name":"thermoreversible gelation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/semipermeable-membranes","display_name":"semipermeable membranes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6959999799728394},{"id":"https://openalex.org/keywords/glucose-challenge-test","display_name":"glucose challenge test","score":0.7620000243186951},{"id":"https://openalex.org/keywords/islet-viability","display_name":"islet viability","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7070000171661377},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7951464056968689},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.7197640538215637},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.6446354389190674},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.5925869345664978},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5692856907844543},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.527638852596283},{"id":"https://openalex.org/C2776892847","wikidata":"https://www.wikidata.org/wiki/Q3395462","display_name":"Poly(N-isopropylacrylamide)","level":4,"score":0.5262585878372192},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.5220377445220947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5154236555099487},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.46386900544166565},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4235530197620392},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4165509343147278},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39411693811416626},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.38112038373947144},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3770645260810852},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36286425590515137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21288391947746277},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13266950845718384},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12041819095611572},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08585983514785767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07254907488822937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0639985203742981},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1525-1594.1996.tb00666.x","doi":"https://doi.org/10.1111/j.1525-1594.1996.tb00666.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-1594.1996.tb00666.x","pdf_url":null,"source":{"id":"https://openalex.org/S40391745","display_name":"Artificial Organs","issn_l":"0160-564X","issn":["0160-564X","1525-1594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Organs","raw_type":"journal-article"},{"id":"pmid:8908335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8908335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial organs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W24173177","https://openalex.org/W1979640404","https://openalex.org/W1982218431","https://openalex.org/W2021010202","https://openalex.org/W2022282748","https://openalex.org/W2025423794","https://openalex.org/W2062866194","https://openalex.org/W2071679458","https://openalex.org/W2092907609","https://openalex.org/W2097835981","https://openalex.org/W2124495875","https://openalex.org/W2418057078"],"related_works":["https://openalex.org/W168688675","https://openalex.org/W2432887060","https://openalex.org/W2007233326","https://openalex.org/W2045757465","https://openalex.org/W2074603849","https://openalex.org/W2011464097","https://openalex.org/W2045784925","https://openalex.org/W2983956391","https://openalex.org/W4402045228","https://openalex.org/W2008629052"],"abstract_inverted_index":{"Various":[0],"materials":[1],"for":[2,6,47,104,167,172,177],"the":[3,56,65,70,83,91,94,119,123,131,135,140,158,164],"semipermeable":[4],"membrane":[5,95],"microencapsulation":[7,168],"of":[8,53,63,93,99,108,125,130,163],"islets,":[9],"such":[10],"as":[11,142],"alginate":[12],"complex":[13],"and":[14,35,62,160],"agarose,":[15],"have":[16],"been":[17],"used.":[18],"In":[19],"this":[20],"study,":[21],"a":[22,97,105,145],"thermoreversible":[23],"gelation":[24],"polymer,":[25],"N-isopropylacrylamide":[26],"based":[27],"copolymer":[28],"was":[29,36],"used":[30,176],"to":[31,81,122,151,174],"make":[32],"microencapsulated":[33,116,136],"islets":[34,89,117],"examined":[37],"in":[38,134,144,179],"vitro.":[39],"The":[40,51,127],"polymer":[41,68],"has":[42],"little":[43],"or":[44],"no":[45],"cytotoxicity":[46],"human":[48],"dermal":[49],"fibroblasts.":[50],"characteristics":[52],"viscoelasticity":[54],"below":[55,69],"soluble":[57,67],"gel":[58],"transition":[59],"temperature":[60],"(SGTT)":[61],"thermoreversibility,":[64],"water":[66,76],"SGTT":[71],"(22":[72],"degrees":[73],"C)":[74],"becoming":[75],"insoluble":[77],"upon":[78],"heating,":[79],"contributed":[80],"simplifying":[82],"encapsulation":[84],"technique.":[85],"We":[86],"obtained":[87],"viable":[88],"at":[90],"center":[92],"with":[96,115],"thickness":[98],"approximately":[100],"20-50":[101],"microns,":[102],"accounting":[103],"40%":[106],"yield":[107],"encapsulated":[109],"islets.":[110],"Static":[111],"glucose":[112],"challenge":[113],"test":[114],"revealed":[118],"insulin":[120,128],"response":[121],"concentration":[124],"glucose.":[126],"concentrations":[129],"culture":[132],"medium":[133],"islet":[137,148],"group":[138,149],"were":[139],"same":[141],"those":[143],"similar":[146],"free":[147],"up":[150],"42":[152],"days.":[153],"These":[154],"results":[155],"indicate":[156],"that":[157],"morphological":[159],"functional":[161],"stability":[162],"new":[165],"method":[166],"may":[169],"be":[170,175],"sufficient":[171],"it":[173],"transplantation":[178],"diabetic":[180],"animals.":[181]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}