{"id":"https://openalex.org/W2050154697","doi":"https://doi.org/10.5551/jat1994.2.14","title":"Smooth Muscle Phenotypes in Developing and Atherosclerotic Human Arteries Demonstrated by Myosin Expression","display_name":"Smooth Muscle Phenotypes in Developing and Atherosclerotic Human Arteries Demonstrated by Myosin Expression","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2050154697","doi":"https://doi.org/10.5551/jat1994.2.14","mag":"2050154697","pmid":"https://pubmed.ncbi.nlm.nih.gov/9225203"},"language":"en","primary_location":{"id":"doi:10.5551/jat1994.2.14","doi":"https://doi.org/10.5551/jat1994.2.14","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1994.2.14","pdf_url":"https://www.jstage.jst.go.jp/article/jat1994/2/1/2_1_14/_pdf","source":{"id":"https://openalex.org/S140063188","display_name":"Journal of Atherosclerosis and Thrombosis","issn_l":"1340-3478","issn":["1340-3478","1880-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis and Thrombosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jat1994/2/1/2_1_14/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064861833","display_name":"Masanori Aikawa","orcid":"https://orcid.org/0000-0002-9275-2079","observed_orcids":["https://orcid.org/0000-0002-9275-2079"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Aikawa","raw_affiliation_strings":["Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","The Department of Cardiology, Juntendo University School of Medicine","The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"The Department of Cardiology, Juntendo University School of Medicine","institution_ids":["https://openalex.org/I34077901"]},{"raw_affiliation_string":"The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074744079","display_name":"Hiroshi Yamaguchi","orcid":"https://orcid.org/0000-0003-4323-1282","observed_orcids":["https://orcid.org/0000-0003-4323-1282"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yamaguchi","raw_affiliation_strings":["The Department of Cardiology, Juntendo University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Cardiology, Juntendo University School of Medicine","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111524529","display_name":"Yoshio Yazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Yazaki","raw_affiliation_strings":["The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113946000","display_name":"Ryozo Nagai","orcid":"https://orcid.org/0000-0002-0911-7868","observed_orcids":["https://orcid.org/0000-0002-0911-7868"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryozo Nagai","raw_affiliation_strings":["The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2648,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.48058122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"14","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.065700002014637,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smooth-muscle-myosin-heavy-chain","display_name":"smooth muscle myosin heavy chain","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mhc-isoforms","display_name":"MHC isoforms","score":0.8920000195503235},{"id":"https://openalex.org/keywords/sm1","display_name":"SM1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/sm2","display_name":"SM2","score":1.0},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-differentiation","display_name":"vascular smooth muscle cell differentiation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.8769999742507935},{"id":"https://openalex.org/keywords/human-aorta","display_name":"human aorta","score":0.906000018119812},{"id":"https://openalex.org/keywords/intimal-thickening","display_name":"intimal thickening","score":0.7720000147819519},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/vascular-development","display_name":"vascular development","score":0.6159999966621399},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.7258644104003906},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7154292464256287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47986477613449097},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4572164714336395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36814653873443604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29769960045814514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2852926254272461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19997495412826538},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09330356121063232},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07986524701118469}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5551/jat1994.2.14","doi":"https://doi.org/10.5551/jat1994.2.14","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1994.2.14","pdf_url":"https://www.jstage.jst.go.jp/article/jat1994/2/1/2_1_14/_pdf","source":{"id":"https://openalex.org/S140063188","display_name":"Journal of Atherosclerosis and Thrombosis","issn_l":"1340-3478","issn":["1340-3478","1880-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis and Thrombosis","raw_type":"journal-article"},{"id":"pmid:9225203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9225203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of atherosclerosis and thrombosis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5551/jat1994.2.14","doi":"https://doi.org/10.5551/jat1994.2.14","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1994.2.14","pdf_url":"https://www.jstage.jst.go.jp/article/jat1994/2/1/2_1_14/_pdf","source":{"id":"https://openalex.org/S140063188","display_name":"Journal of Atherosclerosis and Thrombosis","issn_l":"1340-3478","issn":["1340-3478","1880-3873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Atherosclerosis and Thrombosis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2050154697.pdf"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W260637170","https://openalex.org/W1486851320","https://openalex.org/W1602779577","https://openalex.org/W1603224226","https://openalex.org/W1981429363","https://openalex.org/W2019783518","https://openalex.org/W2057960696","https://openalex.org/W2065449221","https://openalex.org/W2083647583","https://openalex.org/W2097103756","https://openalex.org/W2110808326","https://openalex.org/W2137570167"],"related_works":["https://openalex.org/W260637170","https://openalex.org/W1603224226","https://openalex.org/W2207617662","https://openalex.org/W2106007994","https://openalex.org/W2046539829","https://openalex.org/W2421089420","https://openalex.org/W1512716773","https://openalex.org/W1486851320","https://openalex.org/W2015944633","https://openalex.org/W2052229995"],"abstract_inverted_index":{"Smooth":[0],"muscle":[1,12,87,108,214,254,290,303,315,327],"myosin":[2],"heavy":[3],"chains":[4],"(MHC)":[5],"exist":[6],"in":[7,47,52,67,74,111,119,141,167,185,201,211,226,232,239,280],"multiple":[8],"isoforms.":[9,263],"Rabbit":[10],"smooth":[11,37,86,107,213,253,273,289,314,326],"contain":[13],"at":[14],"least":[15],"three":[16,61,127,259],"types":[17],"of":[18,96,106,138,157,190,204,244,252,271,286,294,336],"MHC":[19,44,62,80,97,109,262,275,316],"isoforms;":[20],"SM1":[21,31,152,175],"(204":[22],"kDa),":[23],"SM2":[24,33,139,197,208,297],"(200":[25,29],"kDa)":[26],"and":[27,32,51,73,77,114,125,134,193],"SMemb":[28,40,165,228],"kDa).":[30],"are":[34,64,82,318],"specific":[35],"to":[36,91,151,159,183,249,258],"muscle,":[38],"but":[39,154,266,298],"is":[41],"a":[42],"nonmuscle-type":[43],"abundantly":[45],"expressed":[46,66],"the":[48,93,104,142,155,168,180,186,191,219,233,240,245,269,281,292,333],"embryonic":[49],"aorta":[50,145,169,192,221],"activated":[53],"mesenchymal":[54],"cells.":[55],"We":[56,122,308],"previously":[57],"reported":[58],"that":[59,79,313],"these":[60,311],"isoforms":[63,81,110,317],"differentially":[65],"rabbit":[68],"during":[69],"normal":[70,188],"vascular":[71,325],"development":[72],"experimental":[75],"arteriosclerosis":[76],"demonstrated":[78],"excellent":[83],"markers":[84,321],"for":[85,261,322],"phenotype.":[88],"In":[89,218,264],"order":[90],"clarify":[92],"clinical":[94],"significance":[95],"isoforms,":[98],"this":[99],"article":[100],"will":[101],"focus":[102],"on":[103],"expression":[105,137,270,293],"normally":[112],"developing":[113],"atherosclerotic":[115],"human":[116,131,143,220,324],"arteries,":[117,195,224],"especially":[118,279],"coronary":[120,194,223,242],"arteries.":[121],"recently":[123],"isolated":[124],"characterized":[126],"cDNA":[128],"clones":[129],"encoding":[130],"SM1,":[132,300],"SM2,":[133],"SMemb.":[135],"The":[136],"mRNA":[140,153,166],"fetal":[144,181,202],"was":[146,161,170,176,198,209,229,247,277,305],"significantly":[147],"lower":[148],"as":[149,330,332],"compared":[150],"ratio":[156],"SM2-":[158],"SM1-mRNA":[160],"increased":[162],"after":[163,172,215],"birth.":[164,173],"decreased":[171],"Immunohistologically,":[174],"constitutively":[177],"positive":[178],"from":[179,310],"stage":[182],"adulthood":[184],"apparently":[187],"media":[189],"whereas":[196,301],"not":[199,295],"detected":[200,230],"arteries":[203,243],"early":[205],"gestational":[206],"stage.":[207,217],"recognized":[210],"well-differentiated":[212,272],"perinatal":[216],"or":[222],"unlike":[225],"rabbit,":[227],"even":[231],"adult.":[234],"Mild":[235],"diffuse":[236],"intimal":[237,288],"thickening":[238],"major":[241],"young":[246],"found":[248],"be":[250],"composed":[251],"cells,":[255],"reacting":[256],"equally":[257],"antibodies":[260],"thickened":[265],"non-atheromatous":[267],"intima,":[268],"muscle-specific":[274],"(SM2)":[276],"reduced,":[278],"deeper":[282],"layer.":[283],"With":[284],"progression":[285],"atherosclerosis,":[287],"diminished":[291],"only":[296],"also":[299],"alpha-smooth":[302],"actin":[304],"well":[306,331],"preserved.":[307],"conclude":[309],"results":[312],"important":[319],"molecular":[320],"studying":[323],"cell":[328],"differentiation":[329],"cellular":[334],"mechanisms":[335],"atherosclerosis.":[337]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
