{"id":"https://openalex.org/W2050147987","doi":"https://doi.org/10.1021/bi00545a016","title":"Inactivation of 3-(3,4-dihydroxyphenyl)alanine decarboxylase by 2-(fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine","display_name":"Inactivation of 3-(3,4-dihydroxyphenyl)alanine decarboxylase by 2-(fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine","publication_year":1980,"publication_date":"1980-02-19","ids":{"openalex":"https://openalex.org/W2050147987","doi":"https://doi.org/10.1021/bi00545a016","mag":"2050147987","pmid":"https://pubmed.ncbi.nlm.nih.gov/7356954"},"language":"en","primary_location":{"id":"doi:10.1021/bi00545a016","doi":"https://doi.org/10.1021/bi00545a016","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00545a016","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047846528","display_name":"Alan L. Maycock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. L. Maycock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071024372","display_name":"Susan D. Aster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. D. Aster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065250230","display_name":"Arthur A. Patchett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Patchett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4751,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.80236376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"19","issue":"4","first_page":"709","last_page":"718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.8036999702453613,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aromatic-l-amino-acid-decarboxylase","display_name":"aromatic L-amino acid decarboxylase","score":0.8019999861717224},{"id":"https://openalex.org/keywords/suicide-inactivation","display_name":"suicide inactivation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/stereospecific-inhibition","display_name":"stereospecific inhibition","score":0.8500000238418579},{"id":"https://openalex.org/keywords/irreversible-enzyme-inhibition","display_name":"irreversible enzyme inhibition","score":0.5600000023841858},{"id":"https://openalex.org/keywords/enzyme-inactivation-mechanism","display_name":"enzyme inactivation mechanism","score":0.6919999718666077},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7950741648674011},{"id":"https://openalex.org/C2778678469","wikidata":"https://www.wikidata.org/wiki/Q411119","display_name":"Ethylamine","level":2,"score":0.767678439617157},{"id":"https://openalex.org/C58824617","wikidata":"https://www.wikidata.org/wiki/Q421186","display_name":"Aromatic L-amino acid decarboxylase","level":3,"score":0.745597243309021},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.6313958764076233},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5791844725608826},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5008525848388672},{"id":"https://openalex.org/C187921627","wikidata":"https://www.wikidata.org/wiki/Q2469470","display_name":"Stereospecificity","level":3,"score":0.4868585467338562},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.4570811092853546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4236734211444855},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.29993677139282227},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17405462265014648},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07125255465507507}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008750","descriptor_name":"Methyldopa","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065105","descriptor_name":"Aromatic Amino Acid Decarboxylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00545a016","doi":"https://doi.org/10.1021/bi00545a016","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00545a016","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7356954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7356954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W152745653","https://openalex.org/W978788698","https://openalex.org/W1413886773","https://openalex.org/W1490024203","https://openalex.org/W1567127782","https://openalex.org/W1625660792","https://openalex.org/W1775749144","https://openalex.org/W1966551810","https://openalex.org/W1970609319","https://openalex.org/W1972757746","https://openalex.org/W1982769606","https://openalex.org/W1983835082","https://openalex.org/W1985470114","https://openalex.org/W1989919880","https://openalex.org/W1991860346","https://openalex.org/W1994748584","https://openalex.org/W1996666734","https://openalex.org/W1997387075","https://openalex.org/W2002910466","https://openalex.org/W2003092157","https://openalex.org/W2007566321","https://openalex.org/W2008087739","https://openalex.org/W2009529981","https://openalex.org/W2010159818","https://openalex.org/W2010820683","https://openalex.org/W2015495507","https://openalex.org/W2030046890","https://openalex.org/W2043014652","https://openalex.org/W2045553639","https://openalex.org/W2046505487","https://openalex.org/W2047956468","https://openalex.org/W2051752092","https://openalex.org/W2052539857","https://openalex.org/W2054979333","https://openalex.org/W2055404553","https://openalex.org/W2057983629","https://openalex.org/W2065074021","https://openalex.org/W2074195035","https://openalex.org/W2077629838","https://openalex.org/W2093714823","https://openalex.org/W2111301002","https://openalex.org/W2161543449","https://openalex.org/W2552318961","https://openalex.org/W2942901958","https://openalex.org/W4406984685"],"related_works":["https://openalex.org/W2161543449","https://openalex.org/W1983835082","https://openalex.org/W1967703275","https://openalex.org/W2006237314","https://openalex.org/W2033207225","https://openalex.org/W139576706","https://openalex.org/W2056176283","https://openalex.org/W1470623888","https://openalex.org/W1974337780","https://openalex.org/W1603519763"],"abstract_inverted_index":{"2-(Fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine":[0],"[alpha-FM-Dopa":[1],"(I)]":[2],"causes":[3],"rapid,":[4],"time-dependent,":[5],"stereospecific,":[6],"and":[7,28,32,56,109],"irreversible":[8],"inhibition":[9],"of":[10,23,38,53,79,96,118,128],"hog":[11],"kidney":[12],"aromatic":[13],"amino":[14],"acid":[15],"(Dopa)":[16],"decarboxylase.":[17],"The":[18,43,66,115],"inactivation":[19,62,67],"occurs":[20],"with":[21,47,121],"loss":[22],"both":[24,107],"the":[25,35,54,61,83,97,124],"carboxyl":[26],"carbon":[27],"fluoride":[29],"from":[30],"I":[31,48,80,102,129],"results":[33],"in":[34,71],"stoichimetric":[36],"formation":[37],"a":[39,50,57,93],"covalent":[40],"enzyme-inhibitor":[41],"adduct.":[42],"data":[44,120],"are":[45],"consistent":[46],"being":[49],"suicide":[51],"inactivator":[52,95],"enzyme,":[55],"plausible":[58],"mechanism":[59],"for":[60],"process":[63],"is":[64,68,74,91,103,130],"presented.":[65],"highly":[69],"efficient":[70],"that":[72],"there":[73],"essentially":[75],"no":[76],"enzymatic":[77],"turnover":[78],"to":[81,105,123],"produce":[82],"corresponding":[84],"amine,":[85],"1-(fluoromethyl)-2-(3,4-dihydroxyphenyl)ethylamine":[86],"[alpha-FM-dopamine":[87],"(II)].":[88],"Amine":[89],"II":[90],"also":[92],"potent":[94],"enzyme.":[98],"In":[99],"vivo":[100],"compound":[101],"found":[104],"inactivate":[106],"brain":[108],"peripheral":[110],"(liver)":[111],"Dopa":[112],"decarboxylase":[113],"activity.":[114],"possible":[116],"significance":[117],"these":[119],"respect":[122],"known":[125],"antihypertensive":[126],"effect":[127],"discussed.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}