{"id":"https://openalex.org/W2050110653","doi":"https://doi.org/10.1016/0145-2126(91)90170-x","title":"N-ras gene mutations in childhood acute non-lymphoblastic leukemia","display_name":"N-ras gene mutations in childhood acute non-lymphoblastic leukemia","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2050110653","doi":"https://doi.org/10.1016/0145-2126(91)90170-x","mag":"2050110653","pmid":"https://pubmed.ncbi.nlm.nih.gov/1921453"},"language":"en","primary_location":{"id":"doi:10.1016/0145-2126(91)90170-x","doi":"https://doi.org/10.1016/0145-2126(91)90170-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0145-2126(91)90170-x","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030927239","display_name":"Naohiro Terada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naohiro Terada","raw_affiliation_strings":["Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206","Division of Basic Sciences, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver Denver, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Division of Basic Sciences, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver Denver, U.S.A","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas J. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281962","display_name":"Raymond and Beverly Sackler Foundation","ror":"https://ror.org/054y39r60","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405281962"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Smith","raw_affiliation_strings":["Raymond and Beverly Sackler Foundation Laboratory, Department of Pediatric Hematology/Oncology, University of Colorado, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Raymond and Beverly Sackler Foundation Laboratory, Department of Pediatric Hematology/Oncology, University of Colorado, U.S.A","institution_ids":["https://openalex.org/I4405281962","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091260162","display_name":"Linda C. Stork","orcid":"https://orcid.org/0000-0002-5708-7800","observed_orcids":["https://orcid.org/0000-0002-5708-7800"]},"institutions":[{"id":"https://openalex.org/I4405281962","display_name":"Raymond and Beverly Sackler Foundation","ror":"https://ror.org/054y39r60","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405281962"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda C. Stork","raw_affiliation_strings":["Raymond and Beverly Sackler Foundation Laboratory, Department of Pediatric Hematology/Oncology, University of Colorado, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Raymond and Beverly Sackler Foundation Laboratory, Department of Pediatric Hematology/Oncology, University of Colorado, U.S.A","institution_ids":["https://openalex.org/I4405281962","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110068281","display_name":"Lorrie Furman Odom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281962","display_name":"Raymond and Beverly Sackler Foundation","ror":"https://ror.org/054y39r60","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405281962"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorrie F. Odom","raw_affiliation_strings":["Raymond and Beverly Sackler Foundation Laboratory, Department of Pediatric Hematology/Oncology, University of Colorado, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Raymond and Beverly Sackler Foundation Laboratory, Department of Pediatric Hematology/Oncology, University of Colorado, U.S.A","institution_ids":["https://openalex.org/I4405281962","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023960478","display_name":"Erwin W. Gelfand","orcid":"https://orcid.org/0000-0002-1256-8918","observed_orcids":["https://orcid.org/0000-0002-1256-8918"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Erwin W. Gelfand","raw_affiliation_strings":["Children's Hospital of Denver, Denver, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Denver, Denver, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023960478"],"corresponding_institution_ids":[],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":null,"fwci":0.2538,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5446583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":"10","first_page":"935","last_page":"941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.722000002861023},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.609000027179718},{"id":"https://openalex.org/keywords/codon-12","display_name":"codon 12","score":0.8539999723434448},{"id":"https://openalex.org/keywords/codon-13","display_name":"codon 13","score":0.9990000128746033},{"id":"https://openalex.org/keywords/codon-61","display_name":"codon 61","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ras-oncogene-activation","display_name":"ras oncogene activation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.6899999976158142},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.8169999718666077},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6383112072944641},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6145241260528564},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5671531558036804},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.5506753325462341},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5063761472702026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5041943788528442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4930226504802704},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4630093574523926},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4198237955570221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3431740403175354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33263951539993286},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32625365257263184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32538866996765137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20785102248191833},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.18172520399093628},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.07137757539749146}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0145-2126(91)90170-x","doi":"https://doi.org/10.1016/0145-2126(91)90170-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0145-2126(91)90170-x","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},{"id":"pmid:1921453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1921453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1066366084","display_name":null,"funder_award_id":"AI-29704","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1652961719","display_name":"IONIC,BIOCHEMICAL,GENETIC BASIS FOR CYCLOSPORIN ACTIVITY","funder_award_id":"5r01ai026490-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2706336764","display_name":"ACTIVATION &TRANSFORMATION OF HUMAN B CELLS BY EB VIRUS","funder_award_id":"5r01ai029704-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6895085112","display_name":null,"funder_award_id":"AI26490","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W17178929","https://openalex.org/W205209830","https://openalex.org/W1965058394","https://openalex.org/W1973800266","https://openalex.org/W1984607452","https://openalex.org/W1993378834","https://openalex.org/W2015936619","https://openalex.org/W2032118018","https://openalex.org/W2032413102","https://openalex.org/W2045322395","https://openalex.org/W2054904912","https://openalex.org/W2064446750","https://openalex.org/W2071697240","https://openalex.org/W2087441022","https://openalex.org/W2087884848","https://openalex.org/W2093674280","https://openalex.org/W2159072093","https://openalex.org/W2159594827","https://openalex.org/W2164034599","https://openalex.org/W2342164073","https://openalex.org/W2396431383","https://openalex.org/W2401655633","https://openalex.org/W2402869749","https://openalex.org/W2410128087","https://openalex.org/W2411699894","https://openalex.org/W2461372596","https://openalex.org/W2467621426"],"related_works":["https://openalex.org/W2076584338","https://openalex.org/W205209830","https://openalex.org/W86438214","https://openalex.org/W1681168297","https://openalex.org/W1998700432","https://openalex.org/W2082205614","https://openalex.org/W2091182142","https://openalex.org/W2061808646","https://openalex.org/W2396431383","https://openalex.org/W2514882693"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}