{"id":"https://openalex.org/W2050108236","doi":"https://doi.org/10.1021/mp9002909","title":"Affinity Enhancement Pretargeting: Synthesis and Testing of a 99mTc-Labeled Bivalent MORF","display_name":"Affinity Enhancement Pretargeting: Synthesis and Testing of a 99mTc-Labeled Bivalent MORF","publication_year":2010,"publication_date":"2010-05-27","ids":{"openalex":"https://openalex.org/W2050108236","doi":"https://doi.org/10.1021/mp9002909","mag":"2050108236","pmid":"https://pubmed.ncbi.nlm.nih.gov/20507096","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2914689"},"language":"en","primary_location":{"id":"doi:10.1021/mp9002909","doi":"https://doi.org/10.1021/mp9002909","is_oa":false,"landing_page_url":"https://doi.org/10.1021/mp9002909","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2914689","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015860537","display_name":"Jiang He","orcid":"https://orcid.org/0000-0001-7600-4604","observed_orcids":["https://orcid.org/0000-0001-7600-4604"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiang He","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365011","display_name":"Yi Wang","orcid":"https://orcid.org/0000-0003-1875-6597","observed_orcids":["https://orcid.org/0000-0003-1875-6597","https://orcid.org/0009-0004-7290-3169"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100848118","display_name":"Shuping Dou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuping Dou","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102006286","display_name":"Xinrong Liu","orcid":"https://orcid.org/0000-0003-1376-2699","observed_orcids":["https://orcid.org/0000-0003-1376-2699"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinrong Liu","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070406660","display_name":"Surong Zhang","orcid":"https://orcid.org/0000-0002-5999-2310","observed_orcids":["https://orcid.org/0000-0002-5999-2310"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surong Zhang","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017451995","display_name":"Guozheng Liu","orcid":"https://orcid.org/0009-0004-6420-0244","observed_orcids":["https://orcid.org/0009-0004-6420-0244","https://orcid.org/0009-0003-4505-4248"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guozheng Liu","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113992277","display_name":"Donald J. Hnatowich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Hnatowich","raw_affiliation_strings":["Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015860537"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8191,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.83659911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"4","first_page":"1118","last_page":"1124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morf","display_name":"MORF","score":0.6909999847412109},{"id":"https://openalex.org/keywords/technetium-99m","display_name":"technetium-99m","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tumor-cell-accumulation","display_name":"tumor cell accumulation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6230000257492065},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"surface plasmon resonance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ls174t-cells","display_name":"LS174T cells","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2777836882","wikidata":"https://www.wikidata.org/wiki/Q22907915","display_name":"Pretargeting","level":5,"score":0.9725548624992371},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8258106708526611},{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.8089652061462402},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.4849303066730499},{"id":"https://openalex.org/C2779931791","wikidata":"https://www.wikidata.org/wiki/Q161515","display_name":"DOTA","level":3,"score":0.46518129110336304},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.45428821444511414},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3442145586013794},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31793999671936035},{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.23518091440200806},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.23273545503616333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2173018455505371},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.18184775114059448},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15928059816360474},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10401573777198792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09124535322189331},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.08140817284584045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060172","descriptor_name":"Morpholinos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/mp9002909","doi":"https://doi.org/10.1021/mp9002909","is_oa":false,"landing_page_url":"https://doi.org/10.1021/mp9002909","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:20507096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20507096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2914689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2914689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Pharm","raw_type":"Text"},{"id":"pmh:oai:escholarship.umassmed.edu:radiology_pubs-1052","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/radiology_pubs/53","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Radiology Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2914689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2914689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Pharm","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2917932180","display_name":"Targeted liposomal radiotherapy of malignant mesothelioma","funder_award_id":"R01CA135358","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4404078109","display_name":"Improved Tumor Radiotherapy by MORF Pretargeting","funder_award_id":"R01CA094994","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5016479622","display_name":null,"funder_award_id":"CA94994","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5892066603","display_name":null,"funder_award_id":"CA135358","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1488749550","https://openalex.org/W1930759784","https://openalex.org/W1966192244","https://openalex.org/W1968971176","https://openalex.org/W1971560677","https://openalex.org/W1978039785","https://openalex.org/W1979530522","https://openalex.org/W1991908200","https://openalex.org/W2005098585","https://openalex.org/W2024222590","https://openalex.org/W2037977222","https://openalex.org/W2050463785","https://openalex.org/W2058970445","https://openalex.org/W2066050999","https://openalex.org/W2074078511","https://openalex.org/W2116671252","https://openalex.org/W2132423819","https://openalex.org/W2133255804","https://openalex.org/W2171291408","https://openalex.org/W2182522952","https://openalex.org/W2184839900","https://openalex.org/W2187747015","https://openalex.org/W2188944400","https://openalex.org/W2302634196","https://openalex.org/W2314148192"],"related_works":["https://openalex.org/W2171291408","https://openalex.org/W2005098585","https://openalex.org/W2314148192","https://openalex.org/W2095321992","https://openalex.org/W1534972325","https://openalex.org/W2276502317","https://openalex.org/W1930759784","https://openalex.org/W3163578499","https://openalex.org/W2050939126","https://openalex.org/W2074078511"],"abstract_inverted_index":{"Pretargeting":[0],"with":[1,96,142,150,164,176,204,227,302],"bivalent":[2,36,69,94,108,191,211,239,266,281,295,319,342],"effectors":[3,37],"capable":[4],"of":[5,51,87,135,207,237,264,278,288,316],"bridging":[6],"antitumor":[7],"antibodies":[8],"(affinity":[9],"enhancement":[10,75,354],"pretargeting)":[11],"has":[12],"been":[13],"reported":[14],"to":[15,91,117,153,166,345],"provide":[16,72],"superior":[17,73],"results":[18,325],"by":[19,57,64,330,349],"affinity":[20,74,256,331,353],"enhancement.":[21,257,332],"Phosphorodiamidate":[22],"morpholinos":[23],"(MORFs)":[24],"and":[25,43,122,128,190,210,222,267,300,352],"other":[26],"DNA":[27],"analogues":[28],"used":[29],"for":[30,101,146,255,308],"pretargeting":[31],"are":[32,40],"ideally":[33],"suited":[34],"as":[35],"since":[38],"they":[39],"easily":[41],"synthesized":[42,299],"the":[44,59,82,107,168,230,235,238,245,265,279,289,309,317,324],"distance":[45],"between":[46,81,187],"binding":[47,83,185],"regions,":[48],"a":[49,93,97,177,294,305,341],"determinant":[50],"binding,":[52],"may":[53,326],"be":[54,322,327],"adjusted":[55],"simply":[56],"lengthening":[58],"chain.":[60],"We":[61],"have":[62],"shown":[63],"surface":[65],"plasmon":[66],"resonance":[67],"that":[68,77,287],"MORFs":[70,192,212,269,336],"will":[71],"provided":[76],"suitable":[78],"spacing":[79,147],"exists":[80],"regions.":[84],"The":[85,170,184],"goals":[86],"this":[88],"study":[89],"were":[90,217,337],"synthesize":[92],"MORF":[95,109,121,141,181,240,247,282,320,343],"MAG(3)":[98],"group":[99],"attached":[100],"technetium-99m":[102],"((99m)Tc)":[103],"radiolabeling,":[104],"investigate":[105],"whether":[106],"showed":[110],"improved":[111],"cell":[112],"accumulation":[113,236,277],"in":[114,125,129,195,219,223,233,313],"culture":[115],"compared":[116,194],"its":[118],"corresponding":[119],"monovalent":[120,189,209,246,268,290,335],"compare":[123],"biodistributions":[124],"normal":[126,220,259],"mice":[127,221,225,315],"pretargeted":[130,203,226,231,314],"tumored":[131,274],"mice.":[132],"An":[133],"excess":[134],"an":[136],"amine":[137],"derivatized":[138],"18":[139],"mer":[140,179],"6":[143],"nonbinding":[144],"bases":[145],"was":[148,174,193,241,270,283,297],"reacted":[149],"Fmoc-l-beta-homoglutamic":[151],"acid":[152],"form":[154],"duplexes":[155],"via":[156],"their":[157],"carboxylate":[158],"groups":[159],"and,":[160],"after":[161],"deprotection,":[162],"conjugated":[163,175,339],"NHS-MAG(3)":[165],"attach":[167],"chelator.":[169],"anti-CEA":[171],"antibody":[172],"MN14":[173],"12":[178],"complementary":[180],"(i.e.,":[182],"cMORF).":[183],"behavior":[186],"radiolabeled":[188,208,280,301,318],"LS174T":[196],"tumor":[197,224,276,311,347],"cells":[198,232],"at":[199,213],"4":[200],"degrees":[201],"C":[202],"MN14-cMORF.":[205,228],"Biodistributions":[206],"3":[214],"h":[215],"postadministration":[216],"measured":[218],"In":[229,258,273,292],"culture,":[234],"significantly":[242,284],"higher":[243,285,310],"than":[244,286],"(p":[248],"=":[249],"0.002),":[250],"thus":[251],"providing":[252],"strong":[253],"evidence":[254],"mice,":[260,275],"whole":[261],"body":[262],"clearance":[263],"equally":[271],"rapid.":[272],"MORF.":[291],"conclusion,":[293],"MAG(3)-MORF":[296],"successfully":[298],"(99m)Tc.":[303],"While":[304],"pharmacokinetic":[306],"effect":[307],"accumulations":[312],"cannot":[321],"excluded,":[323],"best":[328],"explained":[329],"Thus":[333],"two":[334],"covalently":[338],"into":[340],"effector":[344],"improve":[346],"targeting":[348],"both":[350],"pharmacokinetics":[351],"influences.":[355]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}