{"id":"https://openalex.org/W2049865655","doi":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","title":"The C\u2010terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3\u2010kinase and mitogen\u2010activated protein kinase pathways","display_name":"The C\u2010terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3\u2010kinase and mitogen\u2010activated protein kinase pathways","publication_year":2004,"publication_date":"2004-07-27","ids":{"openalex":"https://openalex.org/W2049865655","doi":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","mag":"2049865655","pmid":"https://pubmed.ncbi.nlm.nih.gov/15312177"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2004.02586.x","doi":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02586.x","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02586.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036738804","display_name":"Imane CHAIB-OUKADOUR","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Imane Cha\u00efb\u2010Oukadour","raw_affiliation_strings":["Departament de Bioqu\u00edmica i de Biologia Molecular and Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Bioqu\u00edmica i de Biologia Molecular and Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081211718","display_name":"Carles Gil","orcid":"https://orcid.org/0000-0003-2976-4146","observed_orcids":["https://orcid.org/0000-0003-2976-4146"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carles Gil","raw_affiliation_strings":["Departament de Bioqui\u0301mica i de Biologia Molecular and Institut de Neurocie\u0300ncies, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","Departament de Bioqu\u00edmica i de Biologia Molecular and Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Bioqui\u0301mica i de Biologia Molecular and Institut de Neurocie\u0300ncies, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Departament de Bioqu\u00edmica i de Biologia Molecular and Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034305626","display_name":"Jos\u00e9 Aguilera","orcid":"https://orcid.org/0000-0002-9906-8034","observed_orcids":["https://orcid.org/0000-0002-9906-8034"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Aguilera","raw_affiliation_strings":["Departament de Bioqui\u0301mica i de Biologia Molecular and Institut de Neurocie\u0300ncies, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","Departament de Bioqu\u00edmica i de Biologia Molecular and Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Bioqui\u0301mica i de Biologia Molecular and Institut de Neurocie\u0300ncies, Universitat Auto\u0300noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Departament de Bioqu\u00edmica i de Biologia Molecular and Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain","institution_ids":["https://openalex.org/I123044942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034305626"],"corresponding_institution_ids":["https://openalex.org/I123044942"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.5918,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.62198859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"90","issue":"5","first_page":"1227","last_page":"1236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.843999981880188},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9390000104904175},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8370000123977661},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/p90-ribosomal-s6-kinase","display_name":"p90 ribosomal S6 kinase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9909999966621399},{"id":"https://openalex.org/keywords/akt-pathway","display_name":"AKT pathway","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ras-p21","display_name":"p21ras","score":0.8889999985694885},{"id":"https://openalex.org/keywords/extracellular-potassium","display_name":"extracellular potassium","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neurotrophin-signaling","display_name":"neurotrophin signaling","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5968326926231384},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.560822606086731},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5164139866828918},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5115876793861389},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4754776060581207},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.46892932057380676},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.45286813378334045},{"id":"https://openalex.org/C2909378205","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"MAPK cascade","level":4,"score":0.43401193618774414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4174860119819641},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3660730719566345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3581647276878357},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.35477903485298157},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30028533935546875}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013744","descriptor_name":"Tetanus Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013778","descriptor_name":"Tetrazolium Salts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.2004.02586.x","doi":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02586.x","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:15312177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15312177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1111/j.1471-4159.2004.02586.x","doi":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2004.02586.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02586.x","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2049865655.pdf","grobid_xml":"https://content.openalex.org/works/W2049865655.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W18661633","https://openalex.org/W1540436551","https://openalex.org/W1562796888","https://openalex.org/W1596652845","https://openalex.org/W1779147517","https://openalex.org/W1838901836","https://openalex.org/W1847024738","https://openalex.org/W1894355195","https://openalex.org/W1963764130","https://openalex.org/W1970328692","https://openalex.org/W1993357003","https://openalex.org/W2001920699","https://openalex.org/W2003374744","https://openalex.org/W2014719030","https://openalex.org/W2015243877","https://openalex.org/W2018524477","https://openalex.org/W2027983158","https://openalex.org/W2033500343","https://openalex.org/W2039379548","https://openalex.org/W2039720772","https://openalex.org/W2047081898","https://openalex.org/W2053252892","https://openalex.org/W2059891559","https://openalex.org/W2060865344","https://openalex.org/W2061497413","https://openalex.org/W2063779233","https://openalex.org/W2068842251","https://openalex.org/W2070943156","https://openalex.org/W2072286244","https://openalex.org/W2075449190","https://openalex.org/W2083867490","https://openalex.org/W2085093353","https://openalex.org/W2091858463","https://openalex.org/W2119621239","https://openalex.org/W2120562958","https://openalex.org/W2120939161","https://openalex.org/W2128960139","https://openalex.org/W2146721301","https://openalex.org/W2157423347","https://openalex.org/W2160527711","https://openalex.org/W2170107782","https://openalex.org/W2170306518","https://openalex.org/W2314008482"],"related_works":["https://openalex.org/W2116469209","https://openalex.org/W2074306185","https://openalex.org/W2157733093","https://openalex.org/W2047081898","https://openalex.org/W2070943156","https://openalex.org/W2039379548","https://openalex.org/W2041107670","https://openalex.org/W3094222387","https://openalex.org/W2163121730","https://openalex.org/W2019984318"],"abstract_inverted_index":{"When":[0],"cultured":[1],"cerebellar":[2,189],"granule":[3,190],"neurones":[4],"are":[5,40,54],"transferred":[6],"from":[7],"a":[8],"medium":[9],"containing":[10],"high":[11],"extracellular":[12],"potassium":[13],"concentration":[14],"([K+]e)":[15],"(25":[16],"mm)":[17],"to":[18,74,94,176],"one":[19],"with":[20,42],"lower":[21],"[K+]e":[22],"(5":[23],"mm),":[24],"caspase-3":[25,47],"activity":[26],"is":[27,72,106,160],"induced":[28],"and":[29,51,87,100,113,133,147,182],"cells":[30,36],"die":[31],"apoptotically.":[32],"In":[33,57],"contrast,":[34],"if":[35],"in":[37,129,185],"non-depolarizing":[38],"conditions":[39],"treated":[41],"brain-derived":[43],"neurotrophic":[44],"factor":[45],"(BDNF),":[46],"activity,":[48],"chromatin":[49,89],"condensation":[50],"cell":[52,191],"death":[53],"markedly":[55],"diminished.":[56],"this":[58],"study,":[59],"we":[60],"show":[61],"that":[62],"the":[63,67,76,109,121,136,152,157,168,186],"C-terminal":[64],"domain":[65],"of":[66,84,120,127,135,156,167,171,179,188],"tetanus":[68],"toxin":[69],"heavy-chain":[70],"(Hc-TeTx)":[71],"able":[73],"produce":[75],"same":[77],"neuroprotective":[78],"effect,":[79],"as":[80,105,163,165],"assessed":[81],"by":[82,88,108,193],"reduction":[83],"tetrazolium":[85],"salts":[86],"condensation.":[90],"Hc-TeTx-conferred":[91],"neuroprotection":[92],"appears":[93],"depend":[95],"on":[96],"phosphatidylinositol":[97],"3-kinase":[98],"(PI3K)":[99],"mitogen-activated":[101],"protein":[102],"kinase":[103,123,145],"kinase,":[104],"demonstrated":[107],"selective":[110],"inhibitors":[111],"Wortmannin":[112],"PD98059,":[114],"respectively.":[115],"Hc-TeTx":[116],"also":[117,161],"induces":[118],"phosphorylation":[119,134],"tyrosine":[122],"BDNF":[124],"receptor,":[125],"activation":[126,155],"p21Ras":[128],"its":[130],"GTP-bound":[131],"form,":[132],"cascade":[137],"including":[138],"extracellular-signal-regulated":[139],"kinases-1/2":[140],"(ERK-1/2),":[141],"p90":[142],"ribosomal":[143],"S6":[144],"(p90rsk)":[146],"CREB":[148],"(cAMP-response-element-binding":[149],"protein).":[150],"On":[151],"other":[153],"hand,":[154],"Akt":[158],"pathway":[159],"detected,":[162],"well":[164],"inhibition":[166],"active":[169],"form":[170],"caspase-3.":[172],"These":[173],"results":[174],"point":[175],"an":[177],"implication":[178],"both":[180],"PI3K-":[181],"ERK-dependent":[183],"pathways":[184],"promotion":[187],"survival":[192],"Hc-TeTx.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}