{"id":"https://openalex.org/W2049848426","doi":"https://doi.org/10.1016/j.hlc.2011.05.076","title":"D-Dimer and the Risk of Cardiovascular Disease: The Framingham Heart Study","display_name":"D-Dimer and the Risk of Cardiovascular Disease: The Framingham Heart Study","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2049848426","doi":"https://doi.org/10.1016/j.hlc.2011.05.076","mag":"2049848426"},"language":"en","primary_location":{"id":"doi:10.1016/j.hlc.2011.05.076","doi":"https://doi.org/10.1016/j.hlc.2011.05.076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hlc.2011.05.076","pdf_url":"http://www.heartlungcirc.org/article/S144395061100415X/pdf","source":{"id":"https://openalex.org/S119123570","display_name":"Heart Lung and Circulation","issn_l":"1443-9506","issn":["1443-9506","1444-2892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart, Lung and Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.heartlungcirc.org/article/S144395061100415X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032548401","display_name":"Elizabeth Ann Shaw","orcid":"https://orcid.org/0000-0001-8930-2571","observed_orcids":["https://orcid.org/0000-0001-8930-2571"]},"institutions":[{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"E. Shaw","raw_affiliation_strings":["The Royal North Shore Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal North Shore Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008596377","display_name":"Joseph M. Massaro","orcid":"https://orcid.org/0000-0002-2682-4812","observed_orcids":["https://orcid.org/0000-0002-2682-4812"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Massaro","raw_affiliation_strings":["Boston University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, Boston, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074117194","display_name":"Daniel A Levy","orcid":"https://orcid.org/0000-0003-1843-8724","observed_orcids":["https://orcid.org/0000-0003-1843-8724"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Levy","raw_affiliation_strings":["The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health, Boston, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084614356","display_name":"Christopher J. O\u2019Donnell","orcid":"https://orcid.org/0000-0002-2667-8624","observed_orcids":["https://orcid.org/0000-0002-2667-8624"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. O\u2019Donnell","raw_affiliation_strings":["The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health, Boston, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027561648","display_name":"Ralph B. D\u2019Agostino","orcid":"https://orcid.org/0000-0002-3550-8395","observed_orcids":["https://orcid.org/0000-0002-3550-8395","https://orcid.org/0000-0003-3957-0046"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. D\u2019Agostino","raw_affiliation_strings":["Boston University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, Boston, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089858920","display_name":"Geoffrey H. Tofler","orcid":"https://orcid.org/0000-0001-5922-7259","observed_orcids":["https://orcid.org/0000-0001-5922-7259"]},"institutions":[{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G. Tofler","raw_affiliation_strings":["The Royal North Shore Hospital, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal North Shore Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I2800079252"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032548401"],"corresponding_institution_ids":["https://openalex.org/I2800079252"],"apc_list":{"value":3260,"currency":"USD","value_usd":3260},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.1778493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":null,"first_page":"S30","last_page":"S30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/intravascular-thrombosis","display_name":"intravascular thrombosis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cross-linked-fibrin","display_name":"cross-linked fibrin","score":0.6759999990463257},{"id":"https://openalex.org/keywords/thrombotic-disorders","display_name":"thrombotic disorders","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.640999972820282},{"id":"https://openalex.org/keywords/framingham-offspring-cohort","display_name":"Framingham Offspring cohort","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7794145345687866},{"id":"https://openalex.org/C2779519742","wikidata":"https://www.wikidata.org/wiki/Q198526","display_name":"D-dimer","level":2,"score":0.7392724752426147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6812440156936646},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.6567354202270508},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.5989274382591248},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.5218038558959961},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5114578008651733},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.47640836238861084},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4739779829978943},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4543766379356384},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4355863928794861},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.4245142638683319},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4102933406829834},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37975436449050903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2497771680355072},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.07074084877967834}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.hlc.2011.05.076","doi":"https://doi.org/10.1016/j.hlc.2011.05.076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hlc.2011.05.076","pdf_url":"http://www.heartlungcirc.org/article/S144395061100415X/pdf","source":{"id":"https://openalex.org/S119123570","display_name":"Heart Lung and Circulation","issn_l":"1443-9506","issn":["1443-9506","1444-2892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart, Lung and Circulation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.hlc.2011.05.076","doi":"https://doi.org/10.1016/j.hlc.2011.05.076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.hlc.2011.05.076","pdf_url":"http://www.heartlungcirc.org/article/S144395061100415X/pdf","source":{"id":"https://openalex.org/S119123570","display_name":"Heart Lung and Circulation","issn_l":"1443-9506","issn":["1443-9506","1444-2892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart, Lung and Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2049848426.pdf","grobid_xml":"https://content.openalex.org/works/W2049848426.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2615712842","https://openalex.org/W7096153366","https://openalex.org/W2171101087","https://openalex.org/W2083788705","https://openalex.org/W2079319001","https://openalex.org/W9496502","https://openalex.org/W92516462","https://openalex.org/W130390228","https://openalex.org/W2263288362","https://openalex.org/W2084048335"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}