{"id":"https://openalex.org/W2049803113","doi":"https://doi.org/10.1016/j.semarthrit.2007.04.002","title":"Anakinra in Patients with Treatment-Resistant Adult-Onset Still\u2019s Disease: Four Case Reports with Serial Cytokine Measurements and a Review of the Literature","display_name":"Anakinra in Patients with Treatment-Resistant Adult-Onset Still\u2019s Disease: Four Case Reports with Serial Cytokine Measurements and a Review of the Literature","publication_year":2007,"publication_date":"2007-06-21","ids":{"openalex":"https://openalex.org/W2049803113","doi":"https://doi.org/10.1016/j.semarthrit.2007.04.002","mag":"2049803113","pmid":"https://pubmed.ncbi.nlm.nih.gov/17583775"},"language":"en","primary_location":{"id":"doi:10.1016/j.semarthrit.2007.04.002","doi":"https://doi.org/10.1016/j.semarthrit.2007.04.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semarthrit.2007.04.002","pdf_url":null,"source":{"id":"https://openalex.org/S140349950","display_name":"Seminars in Arthritis and Rheumatism","issn_l":"0049-0172","issn":["0049-0172","1532-866X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Arthritis and Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047316251","display_name":"Ina K\u00f6tter","orcid":"https://orcid.org/0000-0002-9262-005X","observed_orcids":["https://orcid.org/0000-0002-9262-005X"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ina K\u00f6tter","raw_affiliation_strings":["University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany. ina.koetter@med.uni-tuebingen.de","University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany. ina.koetter@med.uni-tuebingen.de","institution_ids":["https://openalex.org/I4210094118"]},{"raw_affiliation_string":"University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander Wacker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Wacker","raw_affiliation_strings":["University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113989761","display_name":"Silvia Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia Koch","raw_affiliation_strings":["University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133197198","display_name":"J\u00f6rg C. Henes","orcid":"https://orcid.org/0000-0001-5940-3195","observed_orcids":["https://orcid.org/0000-0001-5940-3195","https://orcid.org/0000-0002-8385-6861"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Henes","raw_affiliation_strings":["University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007956224","display_name":"Constanze Richter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Constanze Richter","raw_affiliation_strings":["Private Practice, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Practice, Stuttgart, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andreas Engel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Engel","raw_affiliation_strings":["Private Practice, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Practice, Stuttgart, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084243992","display_name":"\u0130lhan G\u00fcnayd\u0131n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ilhan G\u00fcnaydin","raw_affiliation_strings":["University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109843451","display_name":"Lothar Kanz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lothar Kanz","raw_affiliation_strings":["University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital, Department of Internal Medicine II, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047316251"],"corresponding_institution_ids":["https://openalex.org/I4210094118","https://openalex.org/I8087733"],"apc_list":{"value":4370,"currency":"USD","value_usd":4370},"apc_paid":null,"fwci":5.7935,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.96279107,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"37","issue":"3","first_page":"189","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anakinra","display_name":"anakinra","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adult-onset-still-s-disease","display_name":"adult-onset Still's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.6940000057220459},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9229999780654907},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.878000020980835},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7950000166893005},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.8989999890327454},{"id":"https://openalex.org/keywords/disease-activity-assessment","display_name":"disease activity assessment","score":0.6930000185966492},{"id":"https://openalex.org/keywords/glucocorticoid-tapering","display_name":"glucocorticoid tapering","score":0.7179999947547913},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8880000114440918},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.925000011920929},{"id":"https://openalex.org/keywords/toxic-megacolon","display_name":"toxic megacolon","score":0.746999979019165},{"id":"https://openalex.org/keywords/pneumonitis","display_name":"pneumonitis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9686795473098755},{"id":"https://openalex.org/C2781228260","wikidata":"https://www.wikidata.org/wiki/Q415411","display_name":"Anakinra","level":3,"score":0.9596822261810303},{"id":"https://openalex.org/C2778143017","wikidata":"https://www.wikidata.org/wiki/Q111208","display_name":"Erythrocyte sedimentation rate","level":2,"score":0.6290236115455627},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5884166359901428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5857195854187012},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.5723869204521179},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.540382444858551},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.4639800190925598},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4464329779148102},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.4187157154083252},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.34955310821533203},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3268584609031677},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25521039962768555},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.21540892124176025}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016706","descriptor_name":"Still's Disease, Adult-Onset","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016706","descriptor_name":"Still's Disease, Adult-Onset","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016706","descriptor_name":"Still's Disease, Adult-Onset","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.semarthrit.2007.04.002","doi":"https://doi.org/10.1016/j.semarthrit.2007.04.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semarthrit.2007.04.002","pdf_url":null,"source":{"id":"https://openalex.org/S140349950","display_name":"Seminars in Arthritis and Rheumatism","issn_l":"0049-0172","issn":["0049-0172","1532-866X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Arthritis and Rheumatism","raw_type":"journal-article"},{"id":"pmid:17583775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17583775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in arthritis and rheumatism","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W24522532","https://openalex.org/W82618136","https://openalex.org/W125565354","https://openalex.org/W130107031","https://openalex.org/W182517381","https://openalex.org/W207507914","https://openalex.org/W1515994079","https://openalex.org/W1906123493","https://openalex.org/W1974612641","https://openalex.org/W1975501001","https://openalex.org/W1979053750","https://openalex.org/W1991887910","https://openalex.org/W2009611599","https://openalex.org/W2011565665","https://openalex.org/W2011651280","https://openalex.org/W2022685258","https://openalex.org/W2026254148","https://openalex.org/W2030539940","https://openalex.org/W2030665445","https://openalex.org/W2042032563","https://openalex.org/W2042477580","https://openalex.org/W2048462486","https://openalex.org/W2048698451","https://openalex.org/W2056932864","https://openalex.org/W2059117206","https://openalex.org/W2060282267","https://openalex.org/W2064915342","https://openalex.org/W2074477850","https://openalex.org/W2077131491","https://openalex.org/W2077451773","https://openalex.org/W2082442225","https://openalex.org/W2084044339","https://openalex.org/W2093315648","https://openalex.org/W2096881027","https://openalex.org/W2114003336","https://openalex.org/W2115899545","https://openalex.org/W2118066128","https://openalex.org/W2121766816","https://openalex.org/W2133138853","https://openalex.org/W2134911659","https://openalex.org/W2136472793","https://openalex.org/W2143826719","https://openalex.org/W2145147769","https://openalex.org/W2227912200","https://openalex.org/W2232484787","https://openalex.org/W2285880375","https://openalex.org/W2336173440","https://openalex.org/W2396494499","https://openalex.org/W2398149257","https://openalex.org/W2407224121","https://openalex.org/W2407615631","https://openalex.org/W2410423454","https://openalex.org/W2412517747","https://openalex.org/W2413406011","https://openalex.org/W2414375597","https://openalex.org/W2414855593","https://openalex.org/W2431136396","https://openalex.org/W2465740419","https://openalex.org/W2896493787","https://openalex.org/W4234265202","https://openalex.org/W4293429475","https://openalex.org/W6605318069","https://openalex.org/W6714455225"],"related_works":["https://openalex.org/W2048698451","https://openalex.org/W2328284930","https://openalex.org/W2325267532","https://openalex.org/W2908606374","https://openalex.org/W2133938345","https://openalex.org/W2040794665","https://openalex.org/W2146620925","https://openalex.org/W133071173","https://openalex.org/W4402581686","https://openalex.org/W2038796481"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}