{"id":"https://openalex.org/W2049713635","doi":"https://doi.org/10.1371/journal.pone.0075394","title":"The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages","display_name":"The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages","publication_year":2013,"publication_date":"2013-10-09","ids":{"openalex":"https://openalex.org/W2049713635","doi":"https://doi.org/10.1371/journal.pone.0075394","mag":"2049713635","pmid":"https://pubmed.ncbi.nlm.nih.gov/24130708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3793985"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0075394","doi":"https://doi.org/10.1371/journal.pone.0075394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075394","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075394&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075394&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021741541","display_name":"Nicholas Johnson","orcid":"https://orcid.org/0000-0002-8247-2874","observed_orcids":["https://orcid.org/0000-0002-8247-2874"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ","GB"],"is_corresponding":false,"raw_author_name":"Nicholas Johnson","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom ; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic","Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom","Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom ; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I28407311","https://openalex.org/I4210145889"]},{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210145889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031477750","display_name":"Sarah Ha\u00dfdenteufel","orcid":"https://orcid.org/0000-0001-7243-6602","observed_orcids":["https://orcid.org/0000-0001-7243-6602"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah Ha\u00dfdenteufel","raw_affiliation_strings":["Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013274987","display_name":"Melanie Theis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie Theis","raw_affiliation_strings":["Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038494526","display_name":"Adrienne W. Paton","orcid":"https://orcid.org/0000-0002-2996-5733","observed_orcids":["https://orcid.org/0000-0002-2996-5733"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adrienne W. Paton","raw_affiliation_strings":["Research Centre for Infectious Disease, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Infectious Disease, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055597053","display_name":"James C. Paton","orcid":"https://orcid.org/0000-0001-9807-5278","observed_orcids":["https://orcid.org/0000-0001-9807-5278"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James C. Paton","raw_affiliation_strings":["Research Centre for Infectious Disease, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for Infectious Disease, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073218311","display_name":"Richard Zimmermann","orcid":"https://orcid.org/0000-0003-3649-1107","observed_orcids":["https://orcid.org/0000-0003-3649-1107"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Richard Zimmermann","raw_affiliation_strings":["Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068891892","display_name":"Stephen High","orcid":"https://orcid.org/0000-0002-4532-8152","observed_orcids":["https://orcid.org/0000-0002-4532-8152"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen High","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068891892"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3217,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.86328048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"10","first_page":"e75394","last_page":"e75394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.8159999847412109},{"id":"https://openalex.org/keywords/sec61-translocon","display_name":"Sec61 translocon","score":0.9100000262260437},{"id":"https://openalex.org/keywords/sec62","display_name":"Sec62","score":0.8479999899864197},{"id":"https://openalex.org/keywords/sec63","display_name":"SEC63","score":1.0},{"id":"https://openalex.org/keywords/bip","display_name":"BiP","score":0.7649999856948853},{"id":"https://openalex.org/keywords/signal-recognition-particle","display_name":"signal recognition particle","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cotranslational-translocation","display_name":"cotranslational translocation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/membrane-protein-transport","display_name":"membrane protein transport","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7979322671890259},{"id":"https://openalex.org/C113584667","wikidata":"https://www.wikidata.org/wiki/Q16946673","display_name":"Sec61","level":5,"score":0.7958002090454102},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.7323601245880127},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6458169221878052},{"id":"https://openalex.org/C186175293","wikidata":"https://www.wikidata.org/wiki/Q424665","display_name":"Signal recognition particle","level":5,"score":0.5865138173103333},{"id":"https://openalex.org/C199229279","wikidata":"https://www.wikidata.org/wiki/Q610647","display_name":"Translocon","level":4,"score":0.5655070543289185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5333250761032104},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.5080721378326416},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4813852608203888},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.4766193926334381},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.46333587169647217},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.4412177801132202},{"id":"https://openalex.org/C33292294","wikidata":"https://www.wikidata.org/wiki/Q21760416","display_name":"Twin-arginine translocation pathway","level":5,"score":0.41198667883872986},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.3697725534439087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3198161721229553},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.27161985635757446},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.26038944721221924},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2214353382587433},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06251773238182068}],"mesh":[{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pone.0075394","doi":"https://doi.org/10.1371/journal.pone.0075394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075394","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075394&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2787928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3793985","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3793985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3793985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24130708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24130708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/46260cac-fbec-4fbf-88d3-5de9efafa8c9","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/46260cac-fbec-4fbf-88d3-5de9efafa8c9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Johnson, N, Ha\u00dfdenteufel, S, Theis, M, Paton, A W, Paton, J C, Zimmermann, R & High, S 2013, 'The signal sequence influences post-translational ER translocation at distinct stages.', PLoS ONE, vol. 8, no. 10. https://doi.org/10.1371/journal.pone.0075394","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/85570","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/85570","pdf_url":"https://digital.library.adelaide.edu.au/server/api/core/bitstreams/b9fa19db-cd27-4b48-b51c-1ff466432ece/content","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1371/journal.pone.0075394","raw_type":"Journal article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.783.2686","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.783.2686","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a3/9a/pone.0075394.PMC3793985.pdf","raw_type":"text"},{"id":"pmh:oai:asep.lib.cas.cz:CavUnEpca/0399191","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11104/0226527","pdf_url":null,"source":{"id":"https://openalex.org/S7407055266","display_name":"ASEP","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:80462ab3f7d64dafaf35c467d128710e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/80462ab3f7d64dafaf35c467d128710e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 10, p e75394 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/818614","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_The_Signal_Sequence_Influences_Post_Translational_ER_Translocation_at_Distinct_Stages_/818614","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0075394","doi":"https://doi.org/10.1371/journal.pone.0075394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0075394","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075394&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2049713635.pdf","grobid_xml":"https://content.openalex.org/works/W2049713635.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W212748999","https://openalex.org/W1453501771","https://openalex.org/W1553695149","https://openalex.org/W1584935191","https://openalex.org/W1767990444","https://openalex.org/W1852053696","https://openalex.org/W1905262528","https://openalex.org/W1964324370","https://openalex.org/W1973463353","https://openalex.org/W1976215395","https://openalex.org/W1982421065","https://openalex.org/W1982573893","https://openalex.org/W1987515987","https://openalex.org/W1990054050","https://openalex.org/W1993147672","https://openalex.org/W2014199958","https://openalex.org/W2018557658","https://openalex.org/W2019427635","https://openalex.org/W2026070522","https://openalex.org/W2027011407","https://openalex.org/W2028858498","https://openalex.org/W2030048671","https://openalex.org/W2087719108","https://openalex.org/W2094201044","https://openalex.org/W2114616376","https://openalex.org/W2117023179","https://openalex.org/W2117614106","https://openalex.org/W2118278390","https://openalex.org/W2121578462","https://openalex.org/W2129058679","https://openalex.org/W2130370138","https://openalex.org/W2132545929","https://openalex.org/W2145716707","https://openalex.org/W2145932631","https://openalex.org/W2147831582","https://openalex.org/W2151348778","https://openalex.org/W2160340248","https://openalex.org/W2164282000","https://openalex.org/W2169597956","https://openalex.org/W4248568661"],"related_works":["https://openalex.org/W7098519291","https://openalex.org/W2327773816","https://openalex.org/W3016328580","https://openalex.org/W2117023179","https://openalex.org/W1990054050","https://openalex.org/W3216794324","https://openalex.org/W2164282000","https://openalex.org/W1980669547","https://openalex.org/W7095519590","https://openalex.org/W2130370138"],"abstract_inverted_index":{"The":[0],"metazoan":[1],"Sec61":[2,236,262],"translocon":[3],"transports":[4],"polypeptides":[5],"into":[6],"and":[7,23,109,112,125,158,205,212,239],"across":[8],"the":[9,12,35,58,87,102,106,130,135,138,141,146,162,179,192,217,226,240],"membrane":[10,78,88,148,194,245,264],"of":[11,37,60,76,129,242,261],"endoplasmic":[13],"reticulum":[14],"via":[15,195],"two":[16,30],"major":[17],"routes,":[18],"a":[19,24,38,47,98,154,169,196,223,267],"well-established":[20],"co-translational":[21],"pathway":[22,51],"post-translational":[25,50,103],"alternative.":[26],"We":[27],"have":[28],"used":[29],"model":[31,170],"substrates":[32],"to":[33,62,82,86,137,153,177,191,225],"explore":[34],"elements":[36],"secretory":[39,172],"protein":[40,173],"precursor":[41,94,136,224],"that":[42,133,175,199,221,252],"preferentially":[43],"direct":[44],"it":[45],"towards":[46],"co-":[48],"or":[49],"for":[52,123,183,210,244],"ER":[53,64,193,254,272],"translocation.":[54,246],"Having":[55],"first":[56],"determined":[57],"capacity":[59],"precursors":[61,174],"enter":[63],"derived":[65],"microsomes":[66],"post-translationally,":[67],"we":[68],"then":[69],"exploited":[70],"semi-permeabilized":[71],"mammalian":[72,107],"cells":[73],"specifically":[74],"depleted":[75],"key":[77,99],"components":[79,116],"using":[80],"siRNA":[81],"address":[83],"their":[84],"contribution":[85],"translocation":[89,104,149,265],"process.":[90],"These":[91],"studies":[92],"suggest":[93,251],"chain":[95],"length":[96],"is":[97,127,200,214],"factor":[100],"in":[101],"at":[105,266],"ER,":[108,227],"identify":[110],"Sec62":[111,124,204,211],"Sec63":[113,126,213],"as":[114],"important":[115],"acting":[117],"on":[118,161],"this":[119,208,228],"route.":[120],"This":[121],"role":[122],"independent":[128],"signal":[131,142,180,219,255],"sequence":[132,143,220,256],"delivers":[134,222],"ER.":[139],"However,":[140],"can":[144,230,257],"influence":[145,231],"subsequent":[147,232],"process,":[150],"conferring":[151],"sensitivity":[152],"small":[155],"molecule":[156],"inhibitor":[157],"dictating":[159],"reliance":[160],"molecular":[163],"chaperone":[164],"BiP.":[165],"Our":[166],"data":[167,250],"support":[168],"where":[171],"fail":[176],"engage":[178],"recognition":[181],"particle,":[182],"example":[184],"because":[185],"they":[186],"are":[187,189],"short,":[188],"delivered":[190],"distinct":[197],"route":[198],"dependent":[201,271],"upon":[202],"both":[203,235],"Sec63.":[206],"Although":[207],"requirement":[209],"unaffected":[215],"by":[216],"specific":[218,259],"region":[229],"events,":[233],"including":[234],"mediated":[237,263],"transport":[238],"importance":[241],"BiP":[243],"Taken":[247],"together,":[248],"our":[249],"an":[253],"regulate":[258],"aspects":[260],"stage":[268],"following":[269],"Sec62/Sec63":[270],"delivery.":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}