{"id":"https://openalex.org/W2049533855","doi":"https://doi.org/10.1111/j.1365-2265.1974.tb02820.x","title":"THE EFFECT OF THE INTESTINAL POLYPEPTIDES, IRP AND GIP, ON INSULIN|RELEASE AND GLUCOSE TOLERANCE IN THE BABOON","display_name":"THE EFFECT OF THE INTESTINAL POLYPEPTIDES, IRP AND GIP, ON INSULIN|RELEASE AND GLUCOSE TOLERANCE IN THE BABOON","publication_year":1974,"publication_date":"1974-10-01","ids":{"openalex":"https://openalex.org/W2049533855","doi":"https://doi.org/10.1111/j.1365-2265.1974.tb02820.x","mag":"2049533855","pmid":"https://pubmed.ncbi.nlm.nih.gov/4430150"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2265.1974.tb02820.x","doi":"https://doi.org/10.1111/j.1365-2265.1974.tb02820.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1974.tb02820.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024870625","display_name":"D. S. Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D. S. TURNER","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, Surrey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, Surrey","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008135824","display_name":"Lauraine Etheridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"LAURAINE ETHERIDGE","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, Surrey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, Surrey","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103049345","display_name":"Julie P. Jones","orcid":"https://orcid.org/0000-0002-3118-6499","observed_orcids":["https://orcid.org/0000-0002-3118-6499"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JULIE JONES","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, Surrey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, Surrey","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075813771","display_name":"Vincent Marks","orcid":"https://orcid.org/0000-0003-1554-0598","observed_orcids":["https://orcid.org/0000-0003-1554-0598"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"V. MARKS","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, Surrey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, Surrey","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109988387","display_name":"Brian S. Meldrum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. MELDRUM","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, Surrey","MRC Neuropsychiatric Unit, Carshalton, Surrey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, Surrey","institution_ids":["https://openalex.org/I28290843"]},{"raw_affiliation_string":"MRC Neuropsychiatric Unit, Carshalton, Surrey","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113573358","display_name":"S.R. Bloom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. R. BLOOM","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, Surrey","Middlesex Hospital, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, Surrey","institution_ids":["https://openalex.org/I28290843"]},{"raw_affiliation_string":"Middlesex Hospital, London","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108555731","display_name":"John Canvin Brown","orcid":"https://orcid.org/0009-0007-8650-5104","observed_orcids":["https://orcid.org/0009-0007-8650-5104"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"J. C. BROWN","raw_affiliation_strings":["Department of Biochemistry, University of Surrey, Guildford, Surrey","University of British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Surrey, Guildford, Surrey","institution_ids":["https://openalex.org/I28290843"]},{"raw_affiliation_string":"University of British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024870625"],"corresponding_institution_ids":["https://openalex.org/I28290843"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":1.522,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81081774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"3","issue":"4","first_page":"489","last_page":"493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-dependent-insulinotropic-polypeptide","display_name":"glucose-dependent insulinotropic polypeptide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6679999828338623},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.968999981880188},{"id":"https://openalex.org/keywords/oral-glucose","display_name":"oral glucose","score":0.6349999904632568},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.6809999942779541},{"id":"https://openalex.org/keywords/intestinal-hormones","display_name":"intestinal hormones","score":0.8429999947547913},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.8759999871253967},{"id":"https://openalex.org/keywords/primates","display_name":"primates","score":0.5}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8374308943748474},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8344863653182983},{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.8110992312431335},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7771332263946533},{"id":"https://openalex.org/C2776129832","wikidata":"https://www.wikidata.org/wiki/Q22677256","display_name":"Gastric inhibitory polypeptide","level":4,"score":0.7719907760620117},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6371496319770813},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.531823456287384},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5180723667144775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.482372909784317},{"id":"https://openalex.org/C3017594758","wikidata":"https://www.wikidata.org/wiki/Q776862","display_name":"Insulin response","level":4,"score":0.4569876194000244},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.44204413890838623},{"id":"https://openalex.org/C2778108375","wikidata":"https://www.wikidata.org/wiki/Q246978","display_name":"Pancreatic polypeptide","level":4,"score":0.4293060004711151},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.41409504413604736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3292921185493469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1677558720111847},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.15096920728683472},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.13628879189491272}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005768","descriptor_name":"Gastrointestinal Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2265.1974.tb02820.x","doi":"https://doi.org/10.1111/j.1365-2265.1974.tb02820.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1974.tb02820.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},{"id":"pmid:4430150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4430150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1971990975","https://openalex.org/W1976837127","https://openalex.org/W1994989824","https://openalex.org/W2024894572","https://openalex.org/W2055908242","https://openalex.org/W2058761317","https://openalex.org/W2102977341","https://openalex.org/W2144028248"],"related_works":["https://openalex.org/W2010652204","https://openalex.org/W1994123697","https://openalex.org/W1976973369","https://openalex.org/W1968084470","https://openalex.org/W2055908242","https://openalex.org/W2032720730","https://openalex.org/W2163503046","https://openalex.org/W2125820220","https://openalex.org/W2288230135","https://openalex.org/W2040480830"],"abstract_inverted_index":{"The":[0,27,58],"recently":[1,115],"isolated":[2,116],"intestinal":[3,5,87,118],"polypeptides,":[4,117],"insulin":[6,22,43,74,119,186],"releasing":[7,120],"polypeptide":[8,13,121,132],"(IRP)":[9,122],"and":[10,37,109,129],"gastric":[11,130],"inhibitory":[12,131],"(GIP),":[14],"have":[15,138],"been":[16,139],"shown":[17,140],"to":[18,31,141,149,163,170,183,188],"potentiate":[19],"glucose":[20,78,95,151,190,207],"stimulated":[21],"release":[23,44,55,75],"in":[24,34,45,69,91,152,193],"the":[25,35,70,92,146,153,171,177,180,185,194,201],"baboon.":[26],"effect":[28,52,204],"was":[29,56,191],"similar":[30],"that":[32,39,60,86],"seen":[33],"rat":[36,154],"demonstrates":[38],"both":[40],"peptides":[41,182],"affect":[42],"a":[46,174],"broad":[47],"range":[48],"of":[49,73,94,179,200,205],"species.":[50],"No":[51],"on":[53,145,208],"glucagon":[54,209,212],"observed.":[57],"possibility":[59],"either":[61],"IRP":[62],"or":[63,65,173],"GIP,":[64],"both,":[66],"is":[67,82,112],"involved":[68],"alimentary":[71],"augmentation":[72],"by":[76],"oral":[77,206],"deserves":[79],"consideration.":[80],"It":[81],"now":[83],"well":[84],"recognized":[85],"hormones":[88],"are":[89,168],"concerned":[90],"regulation":[93],"homeostasis":[96],"(McIntyre":[97],"et":[98,126,135,156],"al.,":[99,127,136,157],"1964;":[100],"Marks":[101],"&":[102],"Samols,":[103],"1970),":[104],"but":[105],"their":[106],"absolute":[107],"identity":[108],"relative":[110],"importance":[111],"uncertain.":[113],"Two":[114],"(Turner,":[123],"1972;":[124],"Turner":[125],"1973)":[128],"(GIP)":[133],"(Brown":[134],"1969),":[137],"produce":[142],"dramatic":[143],"effects":[144,167],"insulinaemic":[147],"response":[148,187],"intravenous":[150,189],"(Turner":[155],"1973;":[158],"Dupr\u00e9,":[159],"1973).":[160],"In":[161,198],"order":[162],"determine":[164],"whether":[165],"these":[166],"limited":[169],"rat,":[172],"general":[175],"phenomenon,":[176],"ability":[178],"two":[181],"augment":[184],"examined":[192],"baboon,":[195],"Papio":[196],"papio.":[197],"view":[199],"known":[202],"suppressive":[203],"release,":[210],"plasma":[211],"levels":[213],"were":[214],"also":[215],"measured.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}